Data to frequency mappings in various MSK schemes

Minimum shift keying (MSK) is a digital modulation scheme which is suited to demanding applications requiring good bandwidth efficiency and error performance. It can be regarded as continuous phase frequency shift keying (CPFSK) with two signalling frequencies. In general, there is no unique mapping from the input data polarity to the particular signalling frequency during a given bit interval. The simplest formulation maps zeros of the data (marks) to the lower frequency, and ones (spaces) to the higher frequency. Other formulations of MSK employ more complex mappings. The article summarises the most commonly encountered mappings, then shows how to convert from one formulation to another by manipulating the input or output data. It is, therefore, possible to establish communication between different MSK modems employing different formulations of MSK by simple processing of the data     

Measurement techniques for monolithic microwave integrated circuits

Introduces the basic technologies that are associated with measurements of monolithic microwave integrated circuits. The use of test fixtures and wafer probe stations at ambient room temperature is reviewed and their role at thermal and cryogenic temperatures is discussed. With the increasing need for performing non-invasive measurements, advances in experimental field probing techniques are explored     

Advanced intelligent networks: now a reality

This paper looks first at the background to the development of intelligent networking concepts and then tracks this development to the advanced intelligent networks (AINs) of today. The network architecture and basic nodal functions are explained, and a brief review given of the essential intelligent network building blocks, namely the IN (intelligent network) call model and the enhanced CCITT No.7 signalling system. Typical intelligent network services are examined and the tutorial finishes with a review of the latest IN standards     

Phase II study of vinorelbine (Navelbine) in previously treated small cell lung cancer patients. EORTC Lung Cancer Cooperative Group

26 previously treated patients with progressive recurrent small cell lung cancer (SCLC) were given vinorelbine (Navelbine), 30 mg/m2 weekly. All patients had responded to first-line chemotherapy and were off therapy for at least 3 months. Partial response was observed in 4 out of 25 eligible patients (16%; 95% confidence interval 4-36%), stable disease in 7 patients and progression in 12 patients. The limiting toxicity was a non-cumulative leucopenia (80%, 32% WHO grade 3-4). Reaction at the site of injection was observed in 5 patients, causing treatment discontinuation in 2 cases. Other non-haematological toxicities were moderate. These results suggest acceptable toxicity and some antitumour activity of vinorelbine in pretreated SCLC patients.     

What decides: high mortality in paediatric acute renal failure?

Forty paediatric cases of A.R.F. (Acute Renal Failure) of various aetiology were included in the study. 60% of patients were less than 4 years of age with male predominance. 80% cases reported to us very late with oligoanuria of more than 24 hours (2-7 days). Diarrhoea, vomiting and fever were other dominant symptoms. Maximum cases were severely anaemic (87.5%) with mean Hb 7.73 +/- 1.9 gm%. 40% cases were of underweight while only one case (2.5%) was of over weight, inspite of volume excess in 40% cases. All 24 cases, who were estimated for serum albumin, found to have marked hypoalbuminemia. Mortality was found to be as high as 65% inspite of effective peritoneal dialysis in all cases. High mortality seems to be due to profound anuria of many days (because of marked delay in reaching the hospital), fever and malnutrition besides other factors as aetiology.     

Isolation and characterization of three Dictyostelium myosin-I isozymes

Using ion exchange chromatography and an ATP-dependent actin precipitation step, we have isolated three myosin-I isozymes that, together, account for most of the K+EDTA-ATPase activity recovered from extracts of Dictyostelium. The two major myosin-I isozymes, present in approximately equal amounts, had apparent molecular masses of 125 kDa on SDS gels and have been identified by amino acid sequence analysis as the products of the Dictyostelium myosin-IB (DMIB) and myosin-ID (DMID) genes. DMIB, with a specific K+EDTA-ATPase activity 10-fold higher than DMID, was responsible for most of the activity in cell extracts. The third isozyme, present in low amounts, had an apparent molecular mass of 137 kDa on SDS gels and is too large to be the product of any of the known myosin-I genes. DMIB eluted from DE53 cellulose columns as two distinct peaks (II and III). Addition of the phosphatase inhibitor okadaic acid to the extraction buffer increased the fraction of DMIB recovered from growth phase cells in peak III from 35 to 70%. DMIB isolated from peak III, but not from peak II, displayed a significant level of actin-activated MgATPase activity. These results indicate that peak III represents a phosphorylated, actin-activatable form of DMIB.