鄂尔多斯盆地三叠系镜质体反射率与地热史

鄂尔多斯盆地庆36井三叠系镜质体反射率为0.61%～1.06%,其碳化梯度(R_m/km)较高,达0.36%.运用不同方法分析表明,该盆地中生代古地温梯度可达35～57℃/km,高于现今地温梯度.其它地温分析结果支持这一推论.推测高古地温梯度的原因可能是中生代时地壳厚度较薄和中侏罗世末一期热事件.讨论了高古地温梯度对于油气形成与勘探的影响.     

Seismic Behavior of Curtain Walls Containing Insulating Glass Units

In-plane dynamic racking crescendo tests were performed on full-scale curtain wall mock-ups dry glazed with six different insulating glass unit (IGU) configurations and one laminated glass unit configuration. The tests were conducted to determine the serviceability and ultimate limit state behaviors of these configurations tested under simulated earthquake-induced lateral drifts. All IGU configurations tested were manufactured with an annealed monolithic pane and a laminated pane with an argon fill and an anodized aluminum spacer between the panes. Several parameters were varied in the laminated pane of each configuration including glass lite thickness and glass type in the laminated pane (annealed, heat strengthened, and fully tempered), and PVB interlayer thickness for the laminated pane. Properties of the annealed inside pane were not varied. For each configuration, average drift values for the occurrence of glass cracking in each IGU pane, glass fallout from the monolithic pane, and pullout and fallout of the entire glass unit are reported. Relevant damage to the aluminum framing is also reported. Results of these tests can be used to assess the seismic resistance of similarly glazed architectural glass panels in practice and to improve the design of asymmetric IGU configurations for use in seismic regions.     

Development of a loading history for seismic testing of architectural glass in a shop-front wall system

Moderate earthquakes can pose significant threats to the serviceability and structural integrity of the architectural glazing systems that are included in most building envelope systems. Building envelope damage can cause considerable economic losses due to operational disruptions for extended periods following an earthquake. Furthermore, glazing system structural failures are potentially hazardous to both building occupants and pedestrians. In this paper a systematic analytical study of the effect of the SOOE component of the 1940 El Centro earthquake on the response of a one-storey glass and aluminum shop-front wall system is presented. The seismic response of a one-storey commercial building comprised of three reinforced masonry walls, a glass and aluminum shop-front wall system, and a steel bar joist metal deck roof system was determined using the ABAQUS and SAP 90 finite element packages. In this study, the roof was considered incapable of transferring lateral forces to the walls and therefore its stiffness was ignored. Significant differences in the natural frequencies obtained from the two models were observed. These differences can be traced to different elements, different number of elements, different number of concentrated mass and nonstructural mass distribution, and variations in the number of supports used in the two models. For the El Centro ground motions perpendicular to the plane of the shop-front wall, displacements and drifts calculated by the ABAQUS and SAP 90 models differed considerably. This variation was probably due to modelling differences in the front steel frame. For El Centro ground motions parallel to the plane of the shop-front wall, displacements and drifts calculated by the ABAQUS and SAP 90 models were in much better agreement. It should be noted that for testing architectural glass the inplane drifts are more important. Typical values of inplane displacement reached 2.0% of the overall building height of 6.10 m, while the drifts reached 2.8% of the 1.83 m glazing opening.     

High-resolution MR imaging of the rat spinal cord in vivo in a wide-bore magnet at 17.6 Tesla

The objective was to demonstrate the feasibility and to evaluate the performance of high-resolution in vivo magnetic resonance (MR) imaging of the rat spinal cord in a 17.6-T vertical wide-bore magnet. A probehead consisting of a surface coil that offers enlarged sample volume suitable for rats up to a weight of 220 g was designed. ECG triggered and respiratory-gated gradient echo experiments were performed on a Bruker Avance 750 wide-bore spectrometer for high-resolution imaging. With T^*₂ values between 5 and 20 ms, good image contrast could be obtained using short echo times, which also minimizes motion artifacts. Anatomy of healthy spinal cords and pathomorphological changes in traumatically injured rat spinal cord in vivo could be visualized with microscopic detail. It was demonstrated that imaging of the rat spinal cord in vivo using a vertical wide-bore high-magnetic-field system is feasible. The potential to obtain high-resolution images in short scan times renders high-field imaging a powerful diagnostic tool.Volker C. Behr and Thomas Weber contributed equally to this work.     

Plasmodium falciparum stimuli for human gammadelta T cells are related to phosphorylated antigens of mycobacteria

The presence in Plasmodium falciparum of a mitogenic factor for the major human blood gammadelta T-cell subset has been known for years. These gammadelta T cells bearing T-cell receptor Vgamma9 and Vdelta2 variable regions also respond to Mycobacterium tuberculosis, through recognition of several phosphorylated nonpeptidic antigens. In this study, we undertook a better characterization of the malarial stimulus and show that the polygonal activation of Vgamma9/Vdelta2 gammadelta T cells by P. falciparum schizonts is also and exclusively attributable to two phosphorylated malarial compounds. The finding of such stimuli in eukaryotic cells evidence an antigenic link between intracellular parasites as different as Plasmodium and Mycobacterium species. Hence, phosphorylated antigens could be involved in a common pattern of transdisease T-cell responses against various human pathogens.     

A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine

Nonviral gene transfer into the central nervous system (CNS) offers the prospect of providing safe therapies for neurological disorders and manipulating gene expression for studying neuronal function. However, results reported so far have been disappointing. We show that the cationic polymer polyethylenimine (PEI) provides unprecedentedly high levels of transgene expression in the mature mouse brain. Three different preparations of PEI (25-, 50-, and 800-kD) were compared for their transfection efficiencies in the brains of adult mice. The highest levels of transfection were obtained with the 25-kD polymer. With this preparation, DNA/PEI complexes bearing mean ionic charge ratios closest to neutrality gave the best results. Under such conditions, and using a cytomegalovirus (CMV)-luciferase construction, we obtained up to 0.4 10(6) RLU/microgram DNA (equivalent to 0.4 ng of luciferase), which is close to the values obtained using PEI to transfect neuronal cultures and the more easily transfected newborn mouse brain (10(6) RLU/microgram DNA). Widespread expression (over 6 mm3) of marker (luciferase) or functional genes (bcl2) was obtained in neurons and glia after injection into the cerebral cortex, hippocampus, and hypothalamus. Transgene expression was found more than 3 months post-injection in cortical neurons. No morbidity was observed with any of the preparations used. Thus, PEI, a low-toxicity vector, appears to have potential for fundamental research and genetic therapy of the brain.