Near-field thermomechanical response of a waste vault

The near-field thermomechanical response of an immobilized waste disposal vault in crystalline hard rock was numerically studied taking into account the nonlinear behaviour of the host rock. The results of analyses indicate that the temperature dependence of rock properties has relatively little effect on the transient temperature distributions but may increase the thermal stresses and displacements substantially. However, no deep-seated major overstressed zones are expected.     

Simulation evaluation of Gibbs prior distributions for use in maximum a posteriori SPECT reconstructions

The effects of several of Gibbs prior distributions in terms of noise characteristics, edge sharpness, and overall quantitative accuracy of the final estimates obtained from an iterative maximum a posteriori (MAP) procedure applied to data from a realistic chest phantom are demonstrated. The effects of the adjustable parameters built into the prior distribution on these properties are examined. It is found that these parameter values influence the noise and edge characteristics of the final estimate and can generate reconstructions closer to the actual solution than maximum likelihood (ML). In addition, it is found that the choice of the shape of the prior distribution affects the noise characteristics and edge sharpness in the final estimate.     

Glutathione S-Transferase M3 Is Associated with Glycolysis in Intrinsic Temozolomide-Resistant Glioblastoma Multiforme Cells

Glioblastoma multiforme (GBM) is a malignant primary brain tumor. The 5-year relative survival rate of patients with GBM remains <30% on average despite aggressive treatments, and secondary therapy fails in 90% of patients. In chemotherapeutic failure, detoxification proteins are crucial to the activity of chemotherapy drugs. Usually, glutathione S-transferase (GST) superfamily members act as detoxification enzymes by activating xenobiotic metabolites through conjugation with glutathione in healthy cells. However, some overexpressed GSTs not only increase GST activity but also trigger chemotherapy resistance and tumorigenesis-related signaling transductions. Whether GSTM3 is involved in GBM chemoresistance remains unclear. In the current study, we found that T98G, a GBM cell line with pre-existing temozolomide (TMZ) resistance, has high glycolysis and GSTM3 expression. GSTM3 knockdown in T98G decreased glycolysis ability through lactate dehydrogenase A activity reduction. Moreover, it increased TMZ toxicity and decreased invasion ability. Furthermore, we provide next-generation sequencing–based identification of significantly changed messenger RNAs of T98G cells with GSTM3 knockdown for further research. GSTM3 was downregulated in intrinsic TMZ-resistant T98G with a change in the expression levels of some essential glycolysis-related genes. Thus, GSTM3 was associated with glycolysis in chemotherapeutic resistance in T98G cells. Our findings provide new insight into the GSTM3 mechanism in recurring GBM.     

Crystallization behavior of polylactide matrix under the influence of nano‐magnetite

Iron oxide nanoparticle (Fe₃O₄) has gained remarkable research interest for various applications, from environmental to biological, because of its superparamagnetic properties and good biocompatibility. In this work, the nucleation effect of Fe₃O₄ in a polylactide (PLA) matrix under an influence of an alternating magnetic field was studied. The nanocomposite films that is, containing different concentrations of Fe₃O₄ (~8 nm) which were uniformly dispersed in the PLA matrix, were prepared via a solution casting method. The amplitude and frequency of the magnetic field impose great effects on the morphology and nucleation rate of PLA crystallization. Thermogravimetric analysis was used to study the thermal stability of Fe₃O₄/PLA and it showed that the thermal stability of Fe₃O₄/PLA was affected by the Fe₃O₄ content. Fourier transform infrared spectroscopy and X‐ray diffractometry indicated that Fe₃O₄ shows impeding effect to the crystallization of PLA. Based on the differential scanning calorimetry results, composite with 1% of Fe₃O₄ content could promote the crystallization of PLA but it would become an obstacle when 3% of Fe₃O₄ was added. The result of polarized optical microscopy also showed a good agreement that the incorporation of Fe₃O₄ could act as an effective nucleation regent to the composite film. POLYM. ENG. SCI., 59:608–615, 2019. © 2018 Society of Plastics Engineers     

Influence of microstructure and phase composition on the nanoindentation characterization of bioceramic materials based on hydroxyapatite

The aim of the study was to investigate the influence of microstructure and phase composition on the mechanical behaviour of hydroxyapatite (HAp) and biphasic HAp/β-tricalcium phosphate (β-TCP) bioceramic materials using nanoindentation. The formation of β-TCP phase in the HAp ceramic had the predominant influence on the nanomechanical properties of compact ceramics. For investigated microstructures there appear to be a slight decrease in the elastic modulus with increasing load and a higher decrease in hardness, which are in agreement with upper bounds of the results reported in literature. Maximal value of reduced modulus and hardness is yielded with pure HAp, and is measured to be 133.76 GPa for average grain size of 3 μm and 12.18 GPa for average grain size of 140 nm, respectively. The average modulus and hardness results for HAp/β-TCP ceramics with higher (101.61 GPa, 6.76 GPa) and lower grain size (115.72 GPa, 8.76 GPa) show sufficient mechanical properties in order to serve as hard tissue replacement material.     

A programmable integrated digital controller for switching converters with dual-band switching and complex pole-zero compensation

The design of a 0.6-/spl mu/m CMOS programmable integrated digital PID controller for a buck converter is presented. Several novel features are implemented. These include: 1) a dual-band switching scheme for sampling the output voltage for better output resolution; 2) a dual-band switching PWM generator with a modified tapped delay line for area efficiency; 3) a VCO driving a counter to serve as an ADC; 4) a programmable PID compensator employing variable integration times for enhancing accuracy and stability; and 5) complex pole-zero cancellation in extending the bandwidth of the control loop. The converter is designed for variable output applications, and the fast digital loop achieves a tracking time of 50 /spl mu/s for a 1-V step change of the reference voltage. The converter switches at 1 MHz and attains a maximum efficiency of 90% when delivering a load of 125 mW.     

A Breath Ammonia Sensor Based on Conducting Polymer Nanojunctions

We present an ammonia sensor for human breath analysis based on electrically conducting polymer nanojunctions. Each nanojunction is formed by bridging a pair of gold nanoelectrodes on a silicon chip separated by a small gap (<60 nm) with electrodeposited polyaniline. The signal transduction mechanism of the sensor is the change in the nanojunction conductance as a result of polymer dedoping by ammonia. The sensor response to human breath is validated by comparison with a reference method for detection of ammonium ion combined with an optimized breath ammonia trapping system. The nanojunction sensor is capable of in situ detection of parts per billion (ppb) levels of ammonia in human breath.     

Intravascular lymphomatosis: a case presenting with encephalomyelitis and reactive haemophagocytic syndrome diagnosed by renal biopsy

OBJECTIVE: To determine the frequency of characteristics associated with unprotected heterosexual intercourse in HIV infected adults in an urban area. DESIGN: Retrospective comparison of sexual risk transmission behaviour between HIV infected men and women from a drug treatment site and between women from the drug site and HIV infected women from an urban medical centre. METHODS: HIV infected women and men were asked questions on sexual behaviour for a 1 year period before enrollment. The outcome variable was heterosexual risk behaviour (HRB) defined as having vaginal sex at least once in the previous year and not always using condoms. RESULTS: 73% of the drug clinic females, 72% of the drug clinic males, and 42% of the medical centre female engaged in HRB. Using logistic regression analysis, women and men in drug treatment engaged in similar rates of HRB; however, women in drug treatment were four times (95% CI = 2.0-8.3) more likely to engage in HRB risk behaviour than women from the medical centre. CONCLUSION: The data suggest that a surprisingly large portion of HIV infected patients under treatment engaged in HRB, especially former drug users. Without specifically targeted interventions, the heterosexual spread of HIV in urban areas will continue to be a serious problem.