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21.
Omid Bozorg Haddad M. Jahandideh-Tehrani M. A. Mariño 《Water Resources Management》2013,27(7):2071-2073
Zhang et al. (Water Resour Manag doi:10.1007/s11269-012-0182-2, 2012) studied the impacts of climate change and human activities on the runoff for the Huifa River basin. They employed a soil and water assessment tool (SWAT), which was calibrated for the baseline period 1956–1964, and then used to reconstruct the natural runoff for the climate change period 1965–2000. Results showed that both climate change and human activities decrease the observed runoff. Climate change impacts on annual runoff were ?37.7, ?59.5, +36.9, and ?45.2 mm/a for 1965–1975, 1976–1985, 1986–1995, and 1996–2005 respectively, compared with the baseline period 1956–1964. Human activities decreased runoff and caused a relatively larger magnitude impact than those of climate change after 1985. Human activities decreased the annual runoff by ?32.9, ?46.8, ?67.8, and ?54.9 mm/a for 1965–1975, 1976–1985, 1986–1995, and 1996–2005 respectively. Human activities further decreased runoff in wet years due to regulation and storage of water projects. 相似文献
22.
Honey-Bees Mating Optimization (HBMO) Algorithm: A New Heuristic Approach for Water Resources Optimization 总被引:2,自引:3,他引:2
Over the last decade, evolutionary and meta-heuristic algorithms have been extensively used as search and optimization tools in various problem domains, including science, commerce, and engineering. Their broad applicability, ease of use, and global perspective may be considered as the primary reason for their success. The honey-bees mating process may also be considered as a typical swarm-based approach to optimization, in which the search algorithm is inspired by the process of real honey-bees mating. In this paper, the honey-bees mating optimization algorithm (HBMO) is presented and tested with few benchmark examples consisting of highly non-linear constrained and/or unconstrained real-valued mathematical models. The performance of the algorithm is quite comparable with the results of the well-developed genetic algorithm. The HBMO algorithm is also applied to the operation of a single reservoir with 60 periods with the objective of minimizing the total square deviation from target demands. Results obtained are promising and compare well with the results of other well-known heuristic approaches. 相似文献
23.
Danielle Regev Sharon Etzion Hen Haddad Jacob Gopas Aviv Goldbart 《International journal of molecular sciences》2022,23(18)
Cardiovascular morbidity is the leading cause of death of obstructive sleep apnea (OSA) syndrome patients. Nocturnal airway obstruction is associated with intermittent hypoxia (IH). In our previous work with cell lines, incubation with sera from OSA patients induced changes in cell morphology, NF-κB activation and decreased viability. A decrease in beating rate, contraction amplitude and a reduction in intracellular calcium signaling was also observed in human cardiomyocytes differentiated from human embryonic stem cells (hESC-CMs). We expanded these observations using a new controlled IH in vitro system on beating hESC-CMs. The Oxy-Cycler system was programed to generate IH cycles. Following IH, we detected the activation of Hif-1α as an indicator of hypoxia and nuclear NF-κB p65 and p50 subunits, representing pro-inflammatory activity. We also detected the secretion of inflammatory cytokines, such as MIF, PAI-1, MCP-1 and CXCL1, and demonstrated a decrease in beating rate of hESC-CMs following IH. IH induces the co-activation of inflammatory features together with cardiomyocyte alterations which are consistent with myocardial damage in OSA. This study provides an innovative approach for in vitro studies of OSA cardiovascular morbidity and supports the search for new pharmacological agents and molecular targets to improve diagnosis and treatment of patients. 相似文献
24.
Mohamed Haddad Roger Gaudreault Gabriel Sasseville Phuong Trang Nguyen Hannah Wiebe Theo Van De Ven Steve Bourgault Normand Mousseau Charles Ramassamy 《International journal of molecular sciences》2022,23(5)
The overall impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on our society is unprecedented. The identification of small natural ligands that could prevent the entry and/or replication of the coronavirus remains a pertinent approach to fight the coronavirus disease (COVID-19) pandemic. Previously, we showed that the phenolic compounds corilagin and 1,3,6-tri-O-galloyl-β-D-glucose (TGG) inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain (RBD) and angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 target receptor on the cell membrane of the host organism. Building on these promising results, we now assess the effects of these phenolic ligands on two other crucial targets involved in SARS-CoV-2 cell entry and replication, respectively: transmembrane protease serine 2 (TMPRSS2) and 3-chymotrypsin like protease (3CLpro) inhibitors. Since corilagin, TGG, and tannic acid (TA) share many physicochemical and structural properties, we investigate the binding of TA to these targets. In this work, a combination of experimental methods (biochemical inhibition assays, surface plasmon resonance, and quartz crystal microbalance with dissipation monitoring) confirms the potential role of TA in the prevention of SARS-CoV-2 infectivity through the inhibition of extracellular RBD/ACE2 interactions and TMPRSS2 and 3CLpro activity. Moreover, molecular docking prediction followed by dynamic simulation and molecular mechanics Poisson–Boltzmann surface area (MMPBSA) free energy calculation also shows that TA binds to RBD, TMPRSS2, and 3CLpro with higher affinities than TGG and corilagin. Overall, these results suggest that naturally occurring TA is a promising candidate to prevent and inhibit the infectivity of SARS-CoV-2. 相似文献
25.
Alawiya Reslan Juliano G. Haddad Liadrine Moukendza Koundi Philippe Desprs Jean-Loup Bascands Gilles Gadea 《International journal of molecular sciences》2021,22(5)
Mosquito-borne Zika virus (ZIKV) became a real threat to human health due to the lack of vaccine and effective antiviral treatment. The virus has recently been responsible for a global outbreak leading to millions of infected cases. ZIKV complications were highlighted in adults with Guillain–Barré syndrome and in newborns with increasing numbers of congenital disorders ranging from mild developmental delays to fatal conditions. The ability of ZIKV to establish a long-term infection in diverse organs including the kidneys has been recently documented but the consequences of such a viral infection are still debated. Our study aimed to determine whether the efficiency of ZIKV growth in kidney cells relates to glucose concentration. Human kidney HK-2 cells were infected with different ZIKV strains in presence of normal and high glucose concentrations. Virological assays showed a decrease in viral replication without modifying entry steps (viral binding, internalization, fusion) under high glucose conditions. This decrease replication was associated with a lower virus progeny and increased cell viability when compared to ZIKV-infected HK-2 cells in normal glucose concentration. In conclusion, we showed for the first time that an elevated glucose level influences ZIKV replication level with an effect on kidney cell survival. 相似文献
26.
In this paper, a linear viscoelastic material is considered as a dynamic system. From this point of view, a dynamic system identification method is developed for the determination of the relaxation or creep function of the material from dynamic experimental measurements. First, the relation between the relaxation or creep function and the transfer function of the system is established by assuming a model of rational functions of polynomials for the transfer function. Second, a discrete-time system analysis method is introduced to identify the order and parameters of the proposed model from the discretetime series of both the input and output signals. The numerical examples given show that the proposed procedure is reasonable and the model is accurate and efficient. 相似文献
27.
28.
An automated technique is presented for the computation of the doping profiles that minimize the intrinsic fluctuations of
various parameters induced by random doping fluctuations in semiconductor devices. The technique is based on the computation
of the doping sensitivity functions of the parameters under consideration and the constrained minimization of the standard
deviation of fluctuations by using the Lagrange multipliers technique. The technique is then applied to the minimization of
the random doping induced fluctuations of the threshold voltage in 40-nm channel length MOSFET device. 相似文献
29.
W. Brenner G. Haddad H. Detter G. Popovic A. Vujanic N. Delic 《Microsystem Technologies》1997,3(2):68-71
A miniaturized torque sensor based on cable brake principle for the measurement of torque-characteristic of minimotors and
micromotors has been developed. The first generation torque sensor enables the measurement of torque of minimotors in the
range of μNm. Design principles and the production process are described. Experimental results show fair conformity with technical
data for minimotors.
Received: 30 October 1996 / Accepted: 14 November 1996 相似文献
30.
Donatelli S. Haddad S. Sproston J. 《IEEE transactions on pattern analysis and machine intelligence》2009,35(2):224-240
Markov chains are a well-known stochastic process that provide a balance between being able to adequately model the system's behavior and being able to afford the cost of the model solution. The definition of stochastic temporal logics like continuous stochastic logic (CSL) and its variant asCSL, and of their model-checking algorithms, allows a unified approach to the verification of systems, allowing the mix of performance evaluation and probabilistic verification. In this paper we present the stochastic logic CSLTA, which is more expressive than CSL and asCSL, and in which properties can be specified using automata (more precisely, timed automata with a single clock). The extension with respect to expressiveness allows the specification of properties referring to the probability of a finite sequence of timed events. A typical example is the responsiveness property "with probability at least 0.75, a message sent at time 0 by a system A will be received before time 5 by system B and the acknowledgment will be back at A before time 7", a property that cannot be expressed in either CSL or asCSL. We also present a model-checking algorithm for CSLTA. 相似文献