Deciphering the expression dynamics of ANGPTL8 associated regulatory network in insulin resistance using formal modelling approaches

ANGPTL8 is a recently identified novel hormone which regulates both glucose and lipid metabolism. The increase in ANGPTL8 during compensatory insulin resistance has been recently reported to improve glucose tolerance and a part of cytoprotective metabolic circuit. However, the exact signalling entities and dynamics involved in this process have remained elusive. Therefore, the current study was conducted with a specific aim to model the regulation of ANGPTL8 with emphasis on its role in improving glucose tolerance during insulin resistance. The main contribution of this study is the construction of a discrete model (based on kinetic logic of René Thomas) and its equivalent Stochastic Petri Net model of ANGPTL8 associated Biological Regulatory Network (BRN) which can predict its dynamic behaviours. The predicted results of these models are in‐line with the previous experimental observations and provide comprehensive insights into the signalling dynamics of ANGPTL8 associated BRN. The authors’ results support the hypothesis that ANGPTL8 plays an important role in supplementing the insulin signalling pathway during insulin resistance and its loss can aggravate the pathogenic process by quickly leading towards Diabetes Mellitus. The results of this study have potential therapeutic implications for treatment of Diabetes Mellitus and are suggestive of its potential as a glucose‐lowering agent.Inspec keywords: molecular biophysics, biomembranes, diseases, stochastic processes, biochemistry, patient treatment, Petri nets, genetics, sugar, cellular biophysics, biology computingOther keywords: ANGPTL8 associated regulatory network, formal modelling approaches, lipid metabolism, compensatory insulin resistance, glucose tolerance, equivalent Stochastic Petri Net model, ANGPTL8 associated BRN     

Correction to: Deposition of bismuth sulfide and aluminum doped bismuth sulfide thin films for photovoltaic applications

Journal of Materials Science: Materials in Electronics -     

Automated Quality Characterization for Composites Using Hybrid Ultrasonic Imaging Techniques

An enhanced technique using image processing has been developed for automated ultrasonic inspection of composite materials, such as glass/carbon-fibre-reinforced polymer (GFRP or CFRP), to ascertain their structural healthiness. The proposed technique is capable of identifying the abnormality features buried in the composite by image filtering and segmentation applied to ultrasonic C-Scan images. This work presents results performed on two composite samples with simulated delamination defects. A local gating scheme is applied to raw A-Scan data for improved contrast between defective and healthy regions in the produced C-Scan image. In this test campaign, different filtering and thresholding algorithms are evaluated and compared in terms of their effectiveness on defect identification. The accuracies of less than 3 mm and 1.11 mm were attained for the defect size and depth, respectively. The results demonstrates the applicability of the proposed technique for accurate defect localization and characterization of composite materials.     

Advances in the display quality of dye-doped polymer-dispersed liquid crystal films by addition of disc-shaped multidirectional light-control film

Typically, the addition of a dye is considered to increase the contrast ratio (CR) of a polymer-dispersed liquid crystal (PDLC) display; however, with the addition of a small amount of dye, the contrast ratio (CR) unexpectedly decreased as compare to the CR of a normal white PDLC display, attributed to various reasons. In this study, an additional multidirectional light scattering polymer film is developed over a conventional dye-doped polymer-dispersed liquid crystal (DPDLC) film to enhance the CR. For this, a disc-shape (DS) pattern on PN393 film is coated. This structure is believed to enhance the scattering properties of DPDLC displays via multiple-directional scattering nature of DS pattern film. Fabrications of such devices are simple and have advantageous of its low-cost production. This optimal designed disc-shaped light-scattering (DSS) film resulted in the enhancement of the CR of the DPDLCs.     

Stimulation of secondary metabolites by copper and gold nanoparticles in submerge adventitious root cultures of Stevia rebaudiana (Bert.)

Nanotechnology is one of the advance technologies that almost found implications in every field of science. The importance is due to the unique properties of nanoparticles. In this study, bimetallic alloys of copper (Cu) and gold (Au) were tested in submerge root cultures of Stevia rebaudiana for production of biomass and secondary metabolites. A known amount of inoculum roots were submerged in liquid Murashige and Skoog medium containing combination of naphthalene acetic acid (NAA; 0.5 mg l⁻¹) and different ratios of nanoparticles (NPs). NAA augmented medium was used as control. The addition of nanoparticles (30 µg l⁻¹) stimulated biomass accumulation (1.447 g/flask) on 27th day of log phases. The maximum total phenolics content (TPC; 16.17 mg/g‐DW) and total flavonoids content (TFC; 4.20 mg/g‐DW) were displayed using AuCu‐NPs (1:3) and NAA. The same combinations enhanced total phenolic production (TPP; 116 mg/L) and total flavonoid production (TFP; 29.5 mg/L) in submerged cultures. A strong correlation was observed between phenolics, flavonoids and dry biomass. Moreover, maximum 1, 1‐diphenyl‐2‐picrylhydrazyl (DPPH) activity of 79% was displayed by addition of AuCu (1:3) nanoparticles. In conclusion, nanoparticles application has shown a positive effect in enhancing biomass and secondary metabolites production in adventitious root cultures of Stevia rebaudiana.Inspec keywords: bimetals, copper, gold, nanoparticles, renewable materials, bioenergy conversion, toxicology, nanofabrication, nanobiotechnology, biochemistry, molecular biophysicsOther keywords: Au‐Ag, time 27 d, maximum DPPH activity, dry biomass, flavonoids, phenolics, NAA enhanced total phenolic production, total flavonoid content, maximum total phenolic content, log phases, bimetallic NPs stimulated biomass accumulation, NAA augmented medium, naphthalene acetic acid, Skoog medium, liquid Murashige, inoculum roots, culture development, seed‐derived roots, bimetallic alloys, nanotechnology, Stevia rebaudiana (Bert.), submerge adventitious root cultures, gold nanoparticles, copper nanoparticles, secondary metabolites     

Efficient multimedia transmission using adaptive packet bursting for wireless LANs

In addition to an unprecedented 600 Mb/s physical data rate in upcoming standards with greater than 1 Gb/s being considered for future systems, 802.11 has evolved from its earlier incarnations to become a ubiquitous, high-throughput wireless access technology utilized in heterogeneous networks. Although capable of advanced QoS provisioning, commercial 802.11 implementations often support only a subset of QoS specifications, utilize manufacturer-specific QoS enhancements, or use sub-optimal MAC reference specifications with limited capability in achieving optimal system throughput and QoS provisioning.Although more efficient ARQ modes have been defined in the 802.11e and imminent 802.11n amendment standards, opportunities exist within this framework for further optimization through dynamic adaptation of key ARQ-related parameters, which is out of scope of current 802.11 standard specifications. Considering such opportunities, this article presents a novel adaptive ARQ scheme designed to improve the quality and reliability of multimedia transmission through the real-time adaptation of the maximum packet burst size and actual ARQ mode employed. Comprehensive simulation studies show that this scheme can potentially improve the QoS and throughput performance of multimedia traffic in both existing and future 802.11 wireless LANs.     

MODIS satellite data evaluation for sand and dust storm monitoring in Saudi Arabia

ABSTRACT

The impacts of wind-blown desert sand and dust are a major concern of environmental and climate study due to their global extent. This article investigates the sand and dust storms detection in Saudi Arabia using Moderate Resolution Imaging Spectroradiometer (MODIS) data, both from Terra and Aqua satellite systems for the years 2002–2011. Normalized Difference Dust Index (NDDI) is applied for the detection of sand and dust storms whilst MODIS band 31 is applied to discriminate atmospheric sand and dust from that present on the ground. In addition, the data from Meteosat satellite, AERONET station, and meteorological stations are used to validate NDDI-based sand and dust storm events. The results of the study show that NDDI can successfully identify and differentiate sand and dust storms from clouds whilst MODIS band 31 can discriminate aerial and surface sand and dust over Saudi Arabia. The results also show that the multi-source data, that is MODIS, Meteosat, AERONET, and meteorological stations, can be very valuable for tracking sand and dust storm events. As no such attempt in the past has been made in Saudi Arabia, it is envisaged that the results of this study will be helpful in planning remote-sensing data for the climate change study in the region.     

Towards the design and development of a knowledge-based universal modular jigs and fixtures system

Jigs and fixtures are one of the important aspects of manufacturing. Parts may have different sets of fixturing requirements and call for different design strategies. Although there are numerous possibilities for fixture designs, a few basic configurations are clearly identifiable. Computer aided design (CAD) has done a little in assisting designers to design jigs and fixtures, making decisions of the best design selection, and providing designers with suggestions. The goal of this paper is to develop and document the design parameters and specifications utilized in jigs and fixtures design using universal modular jigs and fixtures design system (UMJFS). This is the first step to develop a knowledge-based Jigs and Fixture design and selection system. This application has the advantages of making the fixture design information completely modular and transparent, providing better match to the working conditions, reducing lead-time, and generally providing a significant enhancement of fixture productivity and economy. UMJFS has different standard and modular elements. This makes jigs and fixtures elements interchangeable and reusable. Designing a UMJFS then becomes a task of selecting and assembling the proper elements together.     

Emotional responses to watching and touching 3d emotional face in a virtual environment

Virtual Reality - Facial expressions play a crucial role in modulating the emotional responses in the viewers. Touch is an important factor in shaping human emotions and social communication. The...