Fifth-generation microprocessors

The authors describes the evolution of various microprocessor chip families. Those discussed are: the Pentium chips, the PowerPC chips, The Cyrix 5×86 chips and the AMD-K5 chips. Future evolution is also briefly considered     

Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step

The microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of the lipoproteins containing apolipoprotein B (apoB): very low density lipoproteins and chylomicrons. Evidence indicates that the subclasses of these lipoproteins that contain apoB-48 are assembled in a distinct two-step process; first a relatively lipid-poor primordial lipoprotein precursor is produced, and then bulk neutral lipids are added to form the core of these spherical particles. To determine if either step is mediated by MTP, a series of clonal cell lines stably expressing apoB-53 and MTP was established in non-lipoprotein-producing HeLa cells. MTP activity in these cells was approximately 30%, and apoB secretion was 7-33% of that in HepG2 cells on a molar basis. Despite having robust levels of triglyceride and phospholipid synthesis, these cell lines, as exemplified by HLMB53-59, secreted >90% of the apoB-53 on relatively lipid-poor particles in the density range of 1.063-1.21 g/ml. These results suggested that coexpression of MTP and apoB only reconstituted the first but not the second step in lipoprotein assembly. To extend this observation, additional studies were carried out in McArdle RH-7777 rat hepatoma cells, in which the second step of apoB-48 lipoprotein assembly is well defined. Treatment of these cells with the MTP photoaffinity inhibitor BMS-192951 before pulse labeling with [35S]methionine/cysteine led to an 85% block of both apoB-48 and apoB-100 but not apoAI secretion, demonstrating inhibition of the first step of lipoprotein assembly. After a 30-min [35S]methioneine/cysteine pulse labeling and 120 min of chase, all of the nascent apoB-48 was observed to have a density of high density lipoproteins (1.063-1.21 g/ml), indicating that only the first step of lipoprotein assembly had occurred. The addition of oleic acid to the cell culture media activated the second step as evidenced by the conversion of the apoB-48 high density lipoproteins to very low density lipoproteins (d < 1.006 g/ml) during an extended chase period. Inactivation of MTP after completion of the first step, but before stimulation of the second step by the addition of oleic acid, did not block this conversion. Thus, inhibition of MTP did not hinder the addition of bulk core lipid to the primordial lipoprotein precursor particles, indicating that MTP is not required for the second step of apoB-48 lipoprotein assembly.     

Reliability derivation by cutset approach

The failure event of a system can be expressed as a union of the failures of the cutsets. This expression is then converted to a form where reliability of the system is expressed as an intersection of the complemements of the cutset failures. This last expression is then expanded into the union of mutually exclusive eventsets by applying Ahmed-Jamil Lemmas. Then, the simple substitution of the probabilities of the events in the expanded form realises the reliability of the system. The method is explained with the help of two examples and comparison with other methods is also shown.     

Turbulent flow in a machine honed rough pipe for large Reynolds numbers: General roughness scaling laws

An alternate inner wall variable, for flow over a transitional rough pipe surface, is defined as the ratio of normal coordinate measured above the mean roughness level to the wall roughness scale. The Reynolds equations for mean turbulent flow in a transitional rough pipe, in two layers (inner and outer) are considered. The predictions of the mean velocity and friction factor in fully developed turbulent flow in a rough pipe flow, presented here, covers all types of roughness. The data for a particular case of the machine honed Princeton superpipe roughness, analogous to inflectional type roughness of Nikuradse, is presented, as two expressions using our roughness scale. The velocity profile and friction factor, on a transitional rough wall, are shown to be governed by the new log laws, which are explicitly independent of the transitional wall roughness. Further, the inflectional roughness has also been connected with geometric roughness parameters; like, arithmetic mean roughness, mean peak to valley heights roughness, root mean square (rms), roughness based on texture measure; and the friction factor implicit and approximate explicit formulas have also been proposed. In entire transition region between fully smooth and fully rough wall, monotonic roughness of Colebrook (Moody Chart) over estimaton the friction factor when compared with present inlectional roughness.     

Multilink Solution for Seamless Transition Between Multicast and Unicast Areas in 5G Core Network

Wireless Personal Communications - The exponential growth in technology observed over the past decade has introduced newer ways to exploit network and cyber-physical system-related vulnerabilities....     

Novel Positive Multi-Layer Graph Based Method for Collaborative Filtering Recommender Systems

Recommender systems play an increasingly important role in a wide variety of applications to help users find favorite products. Collaborative filtering has remarkable success in terms of accuracy and becomes one of the most popular recommendation methods. However, these methods have shown unpretentious performance in terms of novelty, diversity, and coverage. We propose a novel graph-based collaborative filtering method, namely Positive Multi-Layer Graph-Based Recommender System (PMLG-RS). PMLG-RS involves a positive multi-layer graph and a path search algorithm to generate recommendations. The positive multi-layer graph consists of two connected layers: the user and item layers. PMLG-RS requires developing a new path search method that finds the shortest path with the highest cost from a source node to every other node. A set of experiments are conducted to compare the PMLG-RS with well-known recommendation methods based on three benchmark datasets, MovieLens-100K, MovieLens-Last, and Film Trust. The results demonstrate the superiority of PMLG-RS and its high capability in making relevant, novel, and diverse recommendations for users.

     

Determining speaker attributes from stress-affected speech in emergency situations with hybrid SVM-DNN architecture

Multimedia Tools and Applications - In the millions of emergency reporting calls made each year, about a quarter are non-emergencies. To avoid responding to such situations, forensic examination of...     

Integrating salient colors with rotational invariant texture features for image representation in retrieval systems

Multimedia Tools and Applications - Content based image retrieval (CBIR) systems allow searching for visually similar images in large collections based on their contents. Visual contents are...     

Combining pixel domain and compressed domain index for sketch based image retrieval

Sketch-based image retrieval (SBIR) lets one express a precise visual query with simple and widespread means. In the SBIR approaches, the challenge consists in representing the image dataset features in a structure that allows one to efficiently and effectively retrieve images in a scalable system. We put forward a sketch-based image retrieval solution where sketches and natural image contours are represented and compared, in both, the compressed-domain of wavelet and in the pixel domain. The query is efficiently performed in the wavelet domain, while effectiveness refinements are achieved using the pixel domain to verify the spatial consistency between the sketch strokes and the natural image contours. Also, we present an efficient scheme of inverted lists for sketch-based image retrieval using the compressed-domain of wavelets. Our proposal of indexing presents two main advantages, the amount of the data to compute the query is smaller than the traditional method while it presents a better effectiveness.     

Synthesis of polyaniline based composite material and its analytical applications for the removal of highly toxic Hg<Superscript>2+</Superscript> metal ion: Antibacterial activity against <Emphasis Type="Italic">E. coli</Emphasis>

A composite material polyaniline-Zr(IV) phosphoborate (PZPB) was synthesized via sol-gel method by the combination of Zr(IV) phosphoborate and polyaniline. The PZPB composite material was characterized by various analytical techniques. The PZPB composite material was found to be selective for Hg²⁺+ metal ion due to the high distribution coefficient values for Hg²⁺+ metal ion in all mediums. The PZPB composite material was used for Hg²⁺+ removal under different experimental conditions. The antibacterial activity of PZPB composite material was also studied against E. coli.