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41.
Elena García-Martín Jos A. G. Agúndez Javier Gmez-Tabales Julin Benito-Len Jorge Milln-Pascual María Díaz-Snchez Patricia Calleja Laura Turpín-Fenoll Hortensia Alonso-Navarro Esteban García-Albea Jos Francisco Plaza-Nieto Felix Javier Jimnez-Jimnez 《International journal of molecular sciences》2022,23(23)
Several recent works have raised the possibility of the contribution of the lymphocyte activation gene 3 (LAG3) protein in the inflammatory processes of multiple sclerosis (MS). Results of studies on the possible association between LAG3 gene variants and the risk of MS have been inconclusive. In this study, we tried to show the possible association between the most common single nucleotide variants (SNVs) in the CD4 and LAG3 genes (these two genes are closely related) and the risk of MS in the Caucasian Spanish population. We studied the genotypes and allelic variants CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 in 300 patients diagnosed with MS and 400 healthy patients using specific TaqMan-based qPCR assays. We analyzed the possible influence of the genotype frequency on age at the onset of MS, the severity of MS, clinical evolutive subtypes of MS, and the HLADRB1*1501 genotype. The frequencies of the CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 genotypes and allelic variants were not associated with the risk of MS and were unrelated to gender, age at onset and severity of MS, the clinical subtype of MS, and HLADRB1*1501 genotype. The results of the current study showed a lack of association between the CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 SNVs and the risk of developing MS in the Caucasian Spanish population. 相似文献
42.
H. J. Escalante S. Rodríguez-Sánchez A. Morales-Reyes J. De La Calleja R. Vazquez 《International journal of remote sensing》2019,40(7):2493-2516
In a world with great challenges in food security, optimising cereal production is critical. Cereals are the most important food source for human consumption. The fourth important cereal worldwide after wheat, rice and maize, is Barley, and its production strongly depends on fertilization treatments. The adoption of suitable fertilizer management strategies often results in large economic benefits to producers. However, determining optimal fertilizer doses for a specific barley variety is complex. The collection of data and their analyses can be cost prohibitive for small farmers regarding time and money. This paper introduces an approach to support producers with automatic tools for the analysis of fertilization management of barley. The proposed methodology aims to simultaneously estimate nitrogen fertilization and barley yield, from information derived from aerial RGB images captured by a UAV. Our long term goal is to provide a low-cost and wide-are-coverage solution for the estimation of barley variables that can be leveraged to increase barley yield without increasing costs. A low-cost UAV is used to capture RGB crop field images. Then, a deep convolutional neural network is used for the automated extraction of features from the images. Extracted features are feed into predictive models that estimate the variables of interest. Experimental results reveal that the proposed methodology is able to reach an accuracy above 83% when estimating nitrogen fertilization and a high correlation and low RMSE in the estimation of yield in grams. Experimental results are promising and will pave the way for the development of deep learning methods for barley analysis from aerial imagery that can be accessed by the average farmer. 相似文献
43.
J Calleja Kempín J Guarnizo Clemente J Martín Cavanna R Vázquez Perfecto P Jiménez Almonacid A Muro de la Fuente 《Canadian Metallurgical Quarterly》1998,90(10):695-700
The main results of the bloodstream infection (BSI) component of the Belgian National Programme for the Surveillance of Hospital Infections (NSIH project) are reported. From October 1992 to September 1996, 117 hospitals (59.1% of Belgian acute-care institutions) reported 13678 nosocomial BSIs. The incidence was 7.05 BSI episodes per 10000 patient-days. The incidence of BSI increased with hospital size and over time. Bloodstream infections were secondary to an infectious body site in 40.3% of the episodes, catheter-related in 23.5%, and of unknown origin in 36.2%. The associated in-hospital mortality was 31.4% and was highest in BSIs secondary to a respiratory tract infection (49.3%). In intensive care units, the incidence of BSI was 38.5 per 10000 patient-days. Coagulase-negative staphylococci were the most prevalent microorganisms (22%), followed by Staphylococcus aureus (14.1%) and Escherichia coli (13.5%). In catheter-related BSIs, these proportions were 41.9%, 18.8%, and 2.3%, respectively. The proportion of polymicrobial episodes was 9.9%. Methicillin resistance in Staphylococcus aureus was 22.3%. With its high participation rate, the NSIH project has characterized the epidemiology of nosocomial BSIs in Belgium during the period studied. 相似文献
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48.
M. A. Sánchez-García E. Calleja F. J. Sanchez F. Calle E. Monroy D. Basak E. Muñoz C. Villar A. Sanz-Hervas M. Aguilar J. J. Serrano J. M. Blanco 《Journal of Electronic Materials》1998,27(4):276-281
GaN layers have been grown by plasma-assisted molecular beam epitaxy on AlN-buffered Si(111) substrates. An initial Al coverage
of the Si substrate of aproximately 3 nm lead to the best AlN layers in terms of x-ray diffraction data, with values of full-width
at half-maximum down to 10 arcmin. A (2×2) surface reconstruction of the AlN layer can be observed when growing under stoichiometry
conditions and for substrate temperatures up to 850°C. Atomic force microscopy reveals that an optimal roughness of 4.6 nm
is obtained for AlN layers grown at 850°C. Optimization in the subsequent growth of the GaN determined that a reduced growth
rate at the beginning of the growth favors the coalescence of the grains on the surface and improves the optical quality of
the film. Following this procedure, an optimum x-ray full-width at half-maximum value of 8.5 arcmin for the GaN layer was
obtained. Si-doped GaN layers were grown with doping concentrations up to 1.7×1019 cm−3 and mobilities approximately 100 cm2/V s. Secondary ion mass spectroscopy measurements of Be-doped GaN films indicate that Be is incorporated in the film covering
more than two orders of magnitude by increasing the Be-cell temperature. Optical activation energy of Be acceptors between
90 and 100 meV was derived from photoluminescence experiments. 相似文献
49.
F. Zouai F. Z. Benabid S. Bouhelal M. E. Cagiao D. Benachour F. J. Baltá Calleja 《Journal of Materials Science》2017,52(8):4345-4355
Nanocomposites based on poly(vinylidene fluoride) (PVDF)/poly(methyl methacrylate) (PMMA) with untreated clay were prepared in one step by reactive melt extrusion. Chemical reactions took place between the polymer matrices, the inorganic clay particles, and three reactive agents, leading to the PVDF/PMMA/clay nanocomposites. The microstructure characterizations were carried out by differential scanning calorimetry and wide-angle X-ray scattering (WAXS). The mechanical behavior was investigated by tensile experiments, impact tests, and microhardness measurements. The morphological characterization was carried out by optical and atomic force microscopy (AFM). The decrease of the melting and crystallization temperatures of the PVDF with the increasing PMMA content is attributed to the interactions between the oxygen of the PMMA carbonyl group and the PVDF’s hydrogen atom. WAXS analysis shows that there is neither an intercalation step nor total exfoliation in any composition. As the PMMA content increases, WAXS diagrams show either the PVDF α-crystallographic form, both, α- and β-forms, or only the β-form. For PMMA contents higher than 40 wt%, the materials became amorphous. The microhardness of the samples decrease for a PMMA content up to 20 wt%. The study by optical microscopy and AFM illustrates the significant effect in the presence of clay on the film’s surface morphology. 相似文献
50.
Luis?David?Notivol?Calleja Salvatore?SpadaroEmail author Jordi?Perelló Gabriel?Junyent 《Photonic Network Communications》2017,34(3):432-444
In an increasingly competitive market environment with smaller product offer differentiation, a continuous maximization of efficiency, while guarantying the quality of the provided services, remains a main objective for any telecom operator. In this work, we address the reduction of the operational costs of the optical transport network as one of the possible fields of action to achieve this aim. We propose to apply cognitive science for reducing these costs, specifically by reducing operation margins. We base our work on the case-based reasoning technique by proposing several new schemes to reduce the operation margins established during the design and commissioning phases of the optical links power budgets. From the obtained results, we find that our cognitive proposal provides a feasible solution allowing significant savings on transmitted power that can reach a 49%. We show that there is a certain dependency on network conditions, achieving higher efficiency in low loaded networks where improvements can raise up to 53%. 相似文献