High-performance simulations of turbulent boundary layer flow using Intel Xeon Phi many-core processors

The Journal of Supercomputing - Direct numerical simulations (DNS) of turbulent flows have increasing importance because they not only provide fundamental understanding of turbulent flows but also...     

Tertiary hash tree-based index structure for high dimensional multimedia data

Dominant features for the content-based image retrieval usually have high-dimensionality. So far, many researches have been done to index such values to support fast retrieval. Still, many existing indexing schemes are suffering from performance degradation due to the curse of dimensionality problem. As an alternative, heuristic algorithms have been proposed to calculate the answer with ??high probability?? at the cost of accuracy. In this paper, we propose a new hash tree-based indexing structure called tertiary hash tree for indexing high-dimensional feature data. Tertiary hash tree provides several advantages compared to the traditional extendible hash structure in terms of resource usage and search performance. Through extensive experiments, we show that our proposed index structure achieves outstanding performance.     

Advanced partial encryption using watermarking and scrambling in MP3

In this paper, we propose an advanced partial encryption of watermarking and scrambling using the magnitude information of Modifed Discrete Cosine Transform (MDCT). In MPEG-1/Audio Layer III (MP3), the magnitude and phase information of modified discrete cosine transform (MDCT) coefficients is encrypted. The proposed method uses both watermarking and scrambling, and aims at protecting the contents against eavesdropping and moreover against illegal mass distribution after descrambled. Experimental results show that the proposed method can achieve higher security and less computational complexity by reusing the MDCT coefficients obtained in MP3.     

Intelligent control of doubly‐fed induction generator systems using PIDNNs

An intelligent control for a stand‐alone doubly‐fed induction generator (DFIG) system using a proportional‐integral‐derivative neural network (PIDNN) is proposed in this study. This system can be applied as a stand‐alone power supply system or as the emergency power system when the electricity grid fails for all sub‐synchronous, synchronous, and super‐synchronous conditions. The rotor side converter is controlled using field‐oriented control to produce 3‐phase stator voltages with constant magnitude and frequency at different rotor speeds. Moreover, the grid side converter, which is also controlled using field‐oriented control, is primarily implemented to maintain the magnitude of the DC‐link voltage. Furthermore, the intelligent PIDNN controller is proposed for both the rotor and grid side converters to improve the transient and steady‐state responses of the DFIG system for different operating conditions. Both the network structure and online learning algorithm are introduced in detail. Finally, the feasibility of the proposed control scheme is verified through experimentation. Copyright © 2011 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society     

Signal tracking method of GNSS receivers for spinning vehicles

A signal tracking method of GNSS receivers for spinning vehicles is proposed in order to eliminate the influence of spinning to the GNSS signal of a vehicle. In the proposed method, a rotation tracking loop is added into the carrier tracking loop of a conventional GNSS receiver. The proposed method was verified through computer simulations and an experiment for live GPS signals. The results show that the proposed method gives an accurate tracking performance.     

Minimal-drift heading measurement using a MEMS gyro for mobile robots: Fused with odometry

To achieve the goal of low-cost MEMS gyros for the precise self-localization of mobile robots, this paper presents a simple, yet effective method to minimize drifts on the heading angle by combining measurements from a gyro with measurements from wheel encoders (odometry). The main idea of the proposed approach is to estimate the accuracy of both sensors as a function of the actual maneuver being carried out, and then the output of both sensors are fused by the complementary filter taking into account the maneuvering conditions. The proposed method is applied to a mobile robot and the experimental data demonstrate the effectiveness of this approach.     

Effect of calcination on characteristics and sintering behaviour of Al2O3-ZrO2 composite powders

The effect of calcination on the characteristics and sintering behaviour of zirconia-toughened alumina (ZTA) composite powders has been investigated. TiO₂ was selected as an additive to promote the sinterability of ZTA powders. The starting materials were Al₂O₃ powder, Zr(OC₃H₇)₄ and Ti(OC₃H₇)₄, and homogeneous ZTA powder containing Zr-O-Ti bonding was prepared. Calcination affected the tetragonalmonoclinic phase transformation temperature of ZrO₂ crystallizing from the gels. Calcination improved the densification rate of ZTA powder compact during sintering, which was attributed to the optimal ZrO₂ particle size and distribution on the surface of alumina. A ZTA specimen with high bulk density and high tetragonal ZrO₂ content was obtained under the conditions of 850°C/1 h calcination and 1500°C/1 h sintering.     

Application of a hybrid finite element method to determine stress intensity factors in unidirectional composites

In this paper a hybrid finite element method is applied in evaluation of the stress intensity factors K _I and K _II of unidirectional fiber reinforced composites. In order to satisfy the stress singularity at the crack tip a singular super-element based on a modified complementary energy principle is developed. The stress and displacement fields in the super-element are expressed in terms of polynomials of two complex variables ₁ and ₂ in the transformed -plane. The stiffness matrix of the super-element was determined by using a line integral along the boundary of the super-element. The displacement vector was expressed in terms of the element nodal displacement vector {q} and a properly selected shape function defined along the element boundary.Numerical results for K _I and K _II of glass-epoxy and graphite-epoxy unidirectional composites with cracks along the diameter of a circular cut out as well as elliptical cut outs were evaluated

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Résumé On applique, dans la présente étude, une méthode d'éléments finis hybrides à l'évaluation des facteurs d'intensité de contrainte K_I et K_II pour des composites renforcés de fibres unidirectionnelles. Pour tenir compte de la singularité de la contrainte à l'extrémité de la fissure, on développe un super élément singulier en se basant sur un principe modifié d'énergie complémentaire. Les champs de contraintes et de déplacements dans le super-élément sont exprimés sous forme polynormale de deux variables complexes ₁, et ₂ dans le plan de la transformée. La matrice de rigidité du super élément est, quant à elle, définie en utilisant une intégrale linéaire le long du contour de l'élément. Le vecteur de déplacement est exprimé par un vecteur (9) de déplacement nodal de l'élément, et par une fonction de forme appropriée, définie le long du contour de l'élément.On évalue les résultats numériques pour K_I et K_II, correspondant à des composites à fibres unidirection-nelles de types verre-epoxy et graphite-epoxy, oú des fissures se situeraient sur le diamètre de découpes circulaires et elliptiques

     

CRISPR/Cas9-Mediated Generation of Pathogen-Resistant Tomato against Tomato Yellow Leaf Curl Virus and Powdery Mildew

Tomato is one of the major vegetable crops consumed worldwide. Tomato yellow leaf curl virus (TYLCV) and fungal Oidium sp. are devastating pathogens causing yellow leaf curl disease and powdery mildew. Such viral and fungal pathogens reduce tomato crop yields and cause substantial economic losses every year. Several commercial tomato varieties include Ty-5 (SlPelo) and Mildew resistance locus o 1 (SlMlo1) locus that carries the susceptibility (S-gene) factors for TYLCV and powdery mildew, respectively. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) is a valuable genome editing tool to develop disease-resistant crop varieties. In this regard, targeting susceptibility factors encoded by the host plant genome instead of the viral genome is a promising approach to achieve pathogen resistance without the need for stable inheritance of CRISPR components. In this study, the CRISPR/Cas9 system was employed to target the SlPelo and SlMlo1 for trait introgression in elite tomato cultivar BN-86 to confer host-mediated immunity against pathogens. SlPelo-knockout lines were successfully generated, carrying the biallelic indel mutations. The pathogen resistance assays in SlPelo mutant lines confirmed the suppressed accumulation of TYLCV and restricted the spread to non-inoculated plant parts. Generated knockout lines for the SlMlo1 showed complete resistance to powdery mildew fungus. Overall, our results demonstrate the efficiency of the CRISPR/Cas9 system to introduce targeted mutagenesis for the rapid development of pathogen-resistant varieties in tomato.     

An Overview of Next-Generation Androgen Receptor-Targeted Therapeutics in Development for the Treatment of Prostate Cancer

Traditional endocrine therapy for prostate cancer (PCa) has been directed at suppression of the androgen receptor (AR) signaling axis since Huggins et al. discovered that diethylstilbestrol (DES; an estrogen) produced chemical castration and PCa tumor regression. Androgen deprivation therapy (ADT) still remains the first-line PCa therapy. Insufficiency of ADT over time leads to castration-resistant PCa (CRPC) in which the AR axis is still active, despite castrate levels of circulating androgens. Despite the approval and use of multiple generations of competitive AR antagonists (antiandrogens), antiandrogen resistance emerges rapidly in CRPC due to several mechanisms, mostly converging in the AR axis. Recent evidence from multiple groups have defined noncompetitive or noncanonical direct binding sites on AR that can be targeted to inhibit the AR axis. This review discusses new developments in the PCa treatment paradigm that includes the next-generation molecules to noncanonical sites, proteolysis targeting chimera (PROTAC), or noncanonical N-terminal domain (NTD)-binding of selective AR degraders (SARDs). A few lead compounds targeting each of these novel noncanonical sites or with SARD activity are discussed. Many of these ligands are still in preclinical development, and a few early clinical leads have emerged, but successful late-stage clinical data are still lacking. The breadth and diversity of targets provide hope that optimized noncanonical inhibitors and/or SARDs will be able to overcome antiandrogen-resistant CRPC.