Electric field controlled electrospray deposition for precise particle pattern and cell pattern formation

Photolithography, soft lithography, and ink jetting have been used for automated micropattern fabrication. However, most of the methods for microfabrication of surface pattern are limited to the investigation of material properties of substrates with high‐cost and complex procedures. In the present study, we show a simple (single‐step) yet versatile and robust approach to generate biodegradable polymeric particle patterns on a substrate using electrospray deposition through a mask. Various particle patterns including patterned dots, circles, squares, and bands can be easily formed and the features of particle patterns could also be tailored using different masks and electrostatic focusing effects. Furthermore, cell patterns can be achieved on the surface of particle patterns by blocking the areas without particle deposition on the substrate and culturing cells on the substrate. Polymeric particle patterns and cell patterns developed in this study could be used in the high throughput screening of sustained release formulations, cell‐based sensing, and drug discovery. In addition to experimental results, an analysis of the associated electric field is used to investigate quantitatively the nature of focusing effect. Scaling analysis is also applied to obtain the dominate terms in electrospray deposition process. © 2010 American Institute of Chemical Engineers AIChE J, 2010     

基于IMS的托管式统一通信（UCaas）研究

文章首先介绍了统一通信（UC）与IP多媒体系统（IMS）特点和关系,然后提出了基于IMS托管式统一通信（UCaaS）业务的体系架构,并从运营商的角度对主要的接入方式、运营模式以及业务优势进行了探讨,最后对UCaaS业务进行了展望。     

Morphology,Electrical, and Rheological Properties of Silane‐Modified Silver Nanowire/Polymer Composites

Electrically conducting films containing AgNws, hydrophilic and hydrophobic resins were prepared. FT‐IR reveals that the interface between the AgNws and epoxy could be successfully modified by APTES. XPS shows that the AgNws were attracted by hydrogen bonds of ? NH₂ and ? NH? groups after APTES modification. SEM analysis shows that the AgNws were well dispersed in the resin. The AgNws were also blended with hydrophilic and acrylic resins, and the resulting blends were compared with AgNws/epoxy blends. Results show that AgNw/PVA‐resin films possess the lowest surface electrical resistance. The AgNw/PVA‐resin and silane‐modified AgNw/epoxy resin conductive films possess a similar electrical percolation threshold.

     

HBP系列成核剂对聚丙烯性能的影响

研究了HBP系列成核剂对聚丙烯性能的影响,并与NA-21成核剂进行了比较。结果表明,对于均聚聚丙烯,HBP-32,HBP-33成核剂具有较好的增刚和增透作用,其效果与NA-21成核剂相当;对于共聚聚丙烯,HBP-34成核剂具有优异的增刚效果,明显好于成核剂NA-21,HBP-32和HBP-33的。     

Advancement of solar desiccant cooling system for building use in subtropical Hong Kong

The solar desiccant cooling system (SDCS) had a saving potential of the year-round primary energy consumption as compared to the conventional air-conditioning system for full fresh air application in the subtropical Hong Kong. In order to further enhance its energy efficiency, advancement of the basic SDCS was carried out through a strategy of hybrid design. Six hybrid system alternatives of SDCS were therefore proposed, three for full fresh air design while another three for return air design for the building zone. Year-round performance evaluation of each solar hybrid desiccant cooling system was conducted for typical office application under different climatic and loading conditions. All the six hybrid system alternatives were found technically feasible, with up to 35.2% saving of year-round primary energy consumption against the conventional air-conditioning systems. Among the hybrid alternatives, recommendations were made on the SDCS hybridized with vapour compression refrigeration for full fresh air design; and the SDCS hybridized with vapour absorption refrigeration for return air design, since they had the saving potentials of both primary energy and initial cost. These two hybrid system alternatives used evacuated tubes, a more economical type of solar collectors compared to the PV or PVT panels.     

On the influence of boundary conditions and thermal radiation on predictive accuracy in numerical simulations of indoor ventilation

Room ventilation is a well studied field, whereby ventilation is either mechanically driven or reliant on buoyancy forces driven by thermal gradients. In office spaces, where occupant comfort is important, the latter (termed displacement ventilation) is sometimes used. In many existing studies, computational methods used to simulate ventilation cases use a number of general engineering assumptions. These can include neglecting heat transfer through the walls, assuming that internal radiative transfer is negligible, or by modelling radiative sources as additional heat loads. In this study, these assumptions are systematically examined by selectively modelling certain phenomena in the simulations. In this way, the accuracy and suitability of such assumptions can be examined with reference to previous experimental work. The variation of radiative absorptivity upon the vertical temperature profile has also been investigated in order to determine the contribution of thermal re-distribution by surface radiation alone, and in addition to radiative participation from the air.     

A novel Markov analytical model for the TCP/AQM systems

A novel closed-loop feedback TCP/AQM(Transfer Control Protocol/Active Queue Management) model is proposed in this paper using a discrete-time Markov chain,and a way to calculate the equilibrium distribution of this model is given.In the model,system time is divided into time slots,the bottleneck router queue model and TCP window size model in each slot are analyzed.Finally,by combining adjacent slots,an integrated TCP/AQM analytical model is developed.By this model,the average values of packets dropping rat...     

Synthesis of N‐Hydroxycinnamides Capped with a Naturally Occurring Moiety as Inhibitors of Histone Deacetylase

Histone deacetylase (HDAC) inhibitors are regarded as promising therapeutics for the treatment of cancer. All reported HDAC inhibitors contain three pharmacophoric features: a zinc‐chelating group, a hydrophobic linker, and a hydrophobic cap for surface recognition. In this study we investigated the effectiveness of osthole, a hydrophobic Chinese herbal compound, as the surface recognition cap in hydroxamate‐based compounds as inhibitors of HDAC. Nine novel osthole‐based N‐hydroxycinnamides were synthesized and screened for enzyme inhibition activity. Compounds 9 d , 9 e , 9 g exhibited inhibitory activities (IC₅₀=24.5, 20.0, 19.6 nM ) against nuclear HDACs in HeLa cells comparable to that of suberoylanilide hydroxamic acid (SAHA; IC₅₀=24.5 nM ), a potent inhibitor clinically used for the treatment of cutaneous T‐cell lymphoma (CTCL). While compounds 9 d and 9 e showed SAHA‐like activity towards HDAC1 and HDAC6, compound 9 g was more selective for HDAC1. Compound 9 d exhibited the best cellular effect, which was comparable to that of SAHA, of enhancing acetylation of either α‐tubulin or histone H3. Molecular docking analysis showed that the osthole moiety of compound 9 d may interact with the same hydrophobic surface pocket exploited by SAHA and it may be modified to provide class‐specific selectivity. These results suggest that osthole is an effective hydrophobic cap when incorporated into N‐hydroxycinnamide‐derived HDAC inhibitors.     

全网业务IT支撑模式的研究

本文介绍了全网业务的定义与类型,结合eTOM分析全网业务对IT支撑系统的要求及其对IT支撑系统带来的挑战,归纳和提炼了全网业务的IT支撑模式。