HAMMER: hierarchical attribute matching mechanism for elastic registration

A new approach is presented for elastic registration of medical images, and is applied to magnetic resonance images of the brain. Experimental results demonstrate very high accuracy in superposition of images from different subjects. There are two major novelties in the proposed algorithm. First, it uses an attribute vector, i.e., a set of geometric moment invariants (GMIs) that are defined on each voxel in an image and are calculated from the tissue maps, to reflect the underlying anatomy at different scales. The attribute vector, if rich enough, can distinguish between different parts of an image, which helps establish anatomical correspondences in the deformation procedure; it also helps reduce local minima, by reducing ambiguity in potential matches. This is a fundamental deviation of our method, referred to as the hierarchical attribute matching mechanism for elastic registration (HAMMER), from other volumetric deformation methods, which are typically based on maximizing image similarity. Second, in order to avoid being trapped by local minima, i.e., suboptimal poor matches, HAMMER uses a successive approximation of the energy function being optimized by lower dimensional smooth energy functions, which are constructed to have significantly fewer local minima. This is achieved by hierarchically selecting the driving features that have distinct attribute vectors, thus, drastically reducing ambiguity in finding correspondence. A number of experiments demonstrate that the proposed algorithm results in accurate superposition of image data from individuals with significant anatomical differences.     

A Novel Switched Parasitic Array and Diversity Scheme Using Horizontally Polarized Linear Antennas

Switched Parasitic Arrays (SPAs) are proposed as an attractive alternative to fully adaptive arrays, due to their compact size and significantly lower cost of development. The main concept of SPAs is the deployment of switches on parasitic elements, which can be properly adjusted, in order to effectively control the radiation pattern of one active element. Conventional SPAs consist of circular arrays of vertically polarized dipoles and parasitic elements. In this paper, a novel SPA design is proposed, which is based on multiple switches employed on the body of horizontally polarized elements (one active and two parasitics). Design considerations are discussed and numerical results are illustrated. Furthermore, a simple diversity scheme is proposed, based on the novel SPA design. Superior performance of the proposed array, relative to simple non-diversity reception schemes, is indicated by simulation results. Stelios A. Mitilineos was born in Athens, Greece, in 1977. He received the Diploma in electrical and computer engineering from the National Technical University of Athens (NTUA), Greece, in October 2001. He is currently working towards his Ph.D. degree in electrical engineering at the same university. His research interests include antennas and propagation, smart antennas and mobile communications, channel estimation and location detection algorithms, MIMO systems and microwave components. Anna E. Andreoudi was born in Thessalonica, Greece, in 1977. She received the Diploma in electrical and computer engineering from the National Technical University of Athens, in 2004. Her research interests include electromagnetic waves propagation and scattering, antenna design and adaptive arrays, wireless communications and wireless mobile networks. Christos N. Capsalis was born in Nafplion, Greece in 1956. He received the Diploma in electrical and mechanical engineering from the National Technical University of Athens in 1979 and the B.S. degree in economics from the University of Athens in 1983. He obtained the Ph.D. degree in electrical engineering from NTUA in 1985. He is currently a Professor at the department of Electrical and Computer Engineering in NTUA. His current scientific activity concerns satellite and mobile communications, antenna theory and design, and electromagnetic compatibility.     

Anaphylaxis to topical bacitracin zinc ointment

This report describes a case of systemic anaphylaxis to bacitracin zinc ointment in a 24-year-old man who was injured in a motorcycle accident. Extensive abrasions on the patient's extremities were cleaned with Shurclens before application of viscous Xylocaine and bacitracin zinc ointment. Five minutes later, the patient exhibited symptoms of severe anaphylaxis and required the administration of epinephrine, antihistamines, intravenous fluids, and corticosteroids. Two weeks later, he underwent prick/puncture skin testing to Shurclens and bacitracin zinc ointment as well as prick/puncture, intracutaneous, and subcutaneous challenge with Xylocaine. Only the result of the prick test to bacitracin zinc ointment was positive. Although bacitracin is considered to be a safe topical antibiotic, physicians should be aware of the potential not only for delayed hypersensitivity but also for acute IgE-mediated allergic reactions and life-threatening anaphylaxis.     

Reactive oxygen species may influence the heat shock response and stress tolerance in the yeast Saccharomyces cerevisiae

Moderate levels of reactive oxygen species (ROS) have been implicated as second messengers in a number of biochemical pathways, and in animal cells have been associated with the activation of the heat shock response (HSR). Here, using an intracellular probe, we demonstrate that differential accumulation of ROS in the yeast Saccharomyces cerevisiae is strongly associated with differential induction of an HS reporter gene over a range of heat shock temperatures. There was a good correlation between cellular ROS levels and the levels of HS-induced reporter gene expression between 37 degrees C and 44 degrees C, both reaching maximal values at 41 degrees C. Furthermore, the addition of 150 microM H2O2 to the yeast cells during heat treatment resulted in a 3 degrees C decrease in the temperature required for maximal induction of the HS expression vector--an increased HS sensitivity that corresponded to a concomitant increase in ROS levels at these lower HS temperatures. Conversely, cells treated with 10 mM of the antioxidant ascorbic acid required a temperature that was 2 degrees C above that required in untreated controls for maximal induction of the HS expression vector. This decreased HS sensitivity corresponded to a decrease in ROS levels at these higher HS temperatures. Finally, cell viability assays reveal that intrinsic thermotolerance remains high in control cells despite concomitant decreases in HS-reporter gene expression and ROS accumulation between 41 degrees C and 44 degrees C. We conclude that the sensitivity of the yeast HSR is strongly associated with ROS accumulation, and suggest that ROS-mediated signalling ensures cooperation between the HS and the antioxidant responses.     

Determining correspondence in 3-D MR brain images using attribute vectors as morphological signatures of voxels

Finding point correspondence in anatomical images is a key step in shape analysis and deformable registration. This paper proposes an automatic correspondence detection algorithm for intramodality MR brain images of different subjects using wavelet-based attribute vectors (WAVs) defined on every image voxel. The attribute vector (AV) is extracted from the wavelet subimages and reflects the image structure in a large neighborhood around the respective voxel in a multiscale fashion. It plays the role of a morphological signature for each voxel, and our goal is, therefore, to make it distinctive of the respective voxel. Correspondence is then determined from similarities of AVs. By incorporating the prior knowledge of the spatial relationship among voxels, the ability of the proposed algorithm to find anatomical correspondence is further improved. Experiments with MR images of human brains show that the algorithm performs similarly to experts, even for complex cortical structures.     

A general form of perfectly matched layers for three-dimensional problems of acoustic scattering in lossless and lossy fluid media

The concept of perfectly matched layer (PML) has been proven very effective in absorbing electromagnetic waves in lossless media. An extension of this method and a complete three-dimensional (3-D) scheme properly suited for finite-difference, time-domain (FDTD) modeling of acoustic propagation and scattering in unbounded problems are presented in this paper. This generalized PML is constructed in such a way that it performs significant absorption of traveling waves in acoustics for both lossless and lossy media. Theoretically, no reflections occur when propagating waves encounter the lossy medium-PML interface, no matter what the angle of incidence is, introducing at the same time the possibility for further wave attenuation via the stretched coordinates idea. Numerical results support the suggested PML theory as well as reveal the proper modifications, which lead to the achievement of the optimum absorbing-boundary condition.     

Rigorous comparison of parabolically tapered and conventional multimode-interference-based 3-dB power splitters in InGaAsP/InP waveguides

Design issues such as optical transmission, interference mechanisms, the splitting ratio, the polarization dependence, and the fabrication tolerances of a compact parabolically tapered multimode-interference (MMI)-based 3-dB power splitter on an InP-based deeply etched ridge waveguide, by use of the finite-element-based beam-propagation method, are presented. The benefits and drawbacks of the use of the tapered structure, in comparison with an untapered MMI-based 3-dB splitter, have also been investigated.     

Context-based caching and routing for P2P web service discovery

In modern heterogeneous environments, such as mobile, pervasive and ad-hoc networks, architectures based on web services offer an attractive solution for effective communication and inter-operation. In such dynamic and rapidly evolving environments, efficient web service discovery is an important task. Usually this task is based on the input/output parameters or other functional attributes, however this does not guarantee the validity or successful utilization of retrieved web services. Instead, non-functional attributes, such as device power features, computational resources and connectivity status, that characterize the context of both service providers and consumers play an important role to the quality and usability of discovery results. In this paper we introduce context-awareness in web service discovery, enabling the provision of the most appropriate services at the right location and time. We focus on context-based caching and routing for improving web service discovery in a mobile peer-to-peer environment. We conducted a thorough experimental study, using our prototype implementation based on the JXTA framework, while simulations are employed for testing the scalability of the approach. We illustrate the advantages that this approach offers, both by evaluating the context-based cache performance and by comparing the efficiency of location-based routing to broadcast-based approaches. Recommended by: Zakaria Maamar     

A distribution-free tabular CUSUM chart for autocorrelated data

A distribution-free tabular CUSUM chart called DFTC is designed to detect shifts in the mean of an autocorrelated process. The chart's Average Run Length (ARL) is approximated by generalizing Siegmund's ARL approximation for the conventional tabular CUSUM chart based on independent and identically distributed normal observations. Control limits for DFTC are computed from the generalized ARL approximation. Also discussed are the choice of reference value and the use of batch means to handle highly correlated processes. The performance of DFTC compared favorably with that of other distribution-free procedures in stationary test processes having various types of autocorrelation functions as well as normal or nonnormal marginals.