Mining Association Rules from Code (MARC) to support legacy software management

This paper presents a methodology for Mining Association Rules from Code (MARC), aiming at capturing program structure, facilitating system understanding and supporting software management. MARC groups program entities (paragraphs or statements) based on similarities, such as variable use, data types and procedure calls. It comprises three stages: code parsing/analysis, association rule mining and rule grouping. Code is parsed to populate a database with records and respective attributes. Association rules are then extracted from this database and subsequently processed to abstract programs into groups containing interrelated entities. Entities are then grouped together if their attributes participate to common rules. This abstraction is performed at the program level or even the paragraph level, in contrast to other approaches that work at the system level. Groups can then be visualised as collections of interrelated entities. The methodology was evaluated using real-life COBOL programs. Results showed that the methodology facilitates program comprehension by using source code only, where domain knowledge and documentation are either unavailable or unreliable.     

Unraveling the Immune Microenvironment of Thymic Epithelial Tumors: Implications for Autoimmunity and Treatment

Thymic Epithelial Tumors (TETs) represent a rare tumor family, originating from the epithelial component of the thymus gland. Clinicopathologically, they are segregated into six major subtypes, associated with distinct histological features and clinical outcomes. Their emergence and evolution are accompanied by the generation of a complex tumor microenvironment (TME), dominated by phenotypically and functionally divergent immune cellular subsets, in different maturation states and in analogies that vary significantly among different subtypes. These heterogenous leukocyte populations exert either immune-permissive and tumor-suppressive functions or vice versa, and the dynamic equilibrium established among them either dictates the tumor immune milieu towards an immune-tolerance state or enables the development of a productive spontaneous tumoricidal response. The immunologically “hot” microenvironment, defining a significant proportion of TETs, makes them a promising candidate for the implementation of immune checkpoint inhibitors (ICIs). A number of phase I and II clinical trials have already demonstrated significant, type-specific clinical efficacy of PD-L1 inhibitors, even though substantial limitations in their utilization derive from their immune-mediated adverse effects. Moreover, the completed clinical studies involved relatively restricted patient samples and an expansion in the enrolled cohorts is required, so that more trustworthy conclusions regarding the benefit from ICIs in TETs can be extracted.     

Performance evaluation of ad hoc routing protocols for military communications

Mobile ad hoc networks (MANETs) are of much interest to both the research community and the military because of the potential to establish a communication network in any situation that involves emergencies. Examples are search‐and‐rescue operations, military deployment in hostile environments, and several types of police operations. One critical open issue is how to route messages considering the characteristics of these networks. The nodes act as routers in an environment without a fixed infrastructure, the nodes are mobile, the wireless medium has its own limitations compared to wired networks, and existing routing protocols cannot be employed, at least without modifications. Over the last few years, a number of routing protocols have been proposed and enhanced to address the issue of routing in MANETs. It is not clear how those different protocols perform under different environments. One protocol may be the best in one network configuration but the worst in another. This article provides an analysis and performance evaluation of those protocols that may be suitable for military communications. The evaluation is conducted in two phases. In the first phase, we compare the protocols based on qualitative metrics to locate those that may fit our evaluation criteria. In the second phase, we evaluate the selected protocols from the first phase based on quantitative metrics in a mobility scenario that reflects tactical military movements. The results disclose that there is no routing protocol in the current stage without modifications that can provide efficient routing to any size of network, regardless of the number of nodes and the network load and mobility. Copyright © 2011 John Wiley & Sons, Ltd.     

Androgen Receptor Gene Pathway Upregulation and Radiation Resistance in Oligometastatic Prostate Cancer

Stereotactic ablative body radiotherapy (SABR) is currently used as a salvage intervention for men with oligometastatic prostate cancer (PC), and increasingly so since the results of the Stereotactic Ablative Body Radiotherapy for the Comprehensive Treatment of Oligometastatic Cancers (SABR-COMET) trial reported a significant improvement in overall survival with SABR. The addition of androgen deprivation therapy (ADT) to localised prostate radiotherapy improves survival as it sensitises PC to radiotherapy-induced cell death. The importance of the androgen receptor (AR) gene pathway in the development of resistance to radiotherapy is well established. In this review paper, we will examine the data to determine how we can overcome the upregulation of the AR pathway and suggest a strategy for improving outcomes in men with oligometastatic hormone-sensitive PC.     

In Situ Characterization of Internal Damage in TRIP‐Steel/Mg‐PSZ Composites under Compressive Stress Using X‐Ray Computed Tomography

An experimental setup for in situ investigations under compressive stress using laboratory X‐ray computed tomography (XCT) was developed and successfully tested. Complete deformation curves can be taken. It could be shown that XCT scans are possible during brakes of the stopped in situ experiments. In this way the deformation behavior of defined sample regions can be investigated. This kind of experiments is well suited to investigate the deformation behavior of foams and other samples which are transferable for the X‐rays used. The compression of metal matrix composite foams lead to the cooperative collapse of connected cells. We observed deformation bands arising in regions of smaller cell wall thicknesses. The deformation was dependent on size, shape, and orientation of the cells under consideration. Obviously deformation bands start at bigger cells with a small cell wall thickness and some extension perpendicular to the deformation direction. The rising of this kind of deformation bands can be explained by the dramatic change of the stress distribution in the neighbor cells after the first brake of a cell wall.     

Optimal control of batteries with fully and partially available rechargeability

Motivated by the increasing dependence of many systems on battery energy, we study the problem of optimally controlling how to discharge and recharge a non-ideal battery so as to maximize the work it can perform over a given time period and still maintain a desired final energy level. Modeling a battery as a dynamic system, we adopt a Kinetic Battery Model (KBM) and formulate a finite-horizon optimal control problem when recharging is always feasible under the constraint that discharging and recharging cannot occur at the same time. The solution is shown to be of bang–bang type with the property that the battery is always in recharging mode during the last part of the interval. When the length of the time horizon exceeds a critical value, we also show that the optimal policy includes chattering. Numerical results are included to illustrate our analysis. We then extend the problem to settings where recharging is only occasionally feasible and show that it can be reduced to a nonlinear optimization problem which can be solved at least numerically.     

Microwave applications of TLM modeling techniques (Invited article)

This article describes the essential features of the transmission-line modeling (TLM) technique and its application to the simulation of the behavior of microwave circuits. Emphasis is placed on presenting the general modeling approach and developments to the model to deal with practical microwave problems. Computational techniques and requirements are discussed with reference to dispersion, coarseness errors, and infinite boundaries. © 1996 John Wiley & Sons, Inc.     

A comparison between the time-domain and the frequency-domain diakoptic methods of solving field problems by transmission-line modelling

The nature and significance of time-domain approximations needed for a diakoptic solution using transmission-line modelling (TLM) are examined. Truncation, filtering and repeated convolution of time responses result in severe restrictions in the accuracy of time-domain diakoptics. The frequency-domain diakoptic method has several advantages, including speed and simplicity, and warrants further study.     

ON THE DYNAMIC PROPERTIES OF THE EXTENSIVE VARIABLE CONTROL STRUCTURES

The purpose of this paper is to investigate the dynamic properties of controller structures synthesized using extensive thermodynamic variables of a process. Several state-space and frequency domain multivariable techniques, including INA, and Modal Interaction Analysis, are used in order to evaluate the dynamic properties of these control structures. These structures show zero steady state interaction and minimal dynamic interaction for all processes examined. Dynamic simulation of several application examples, including distillation columns and a network of two stirred tank heaters in series, shows that the loops in these structures can also be tuned with minimum effort. Comparison of the proposed structures, with the conventional parallel single-input single-output control structures, shows the advantages of the proposed method.