Multimedia ontology population through semantic analysis and hierarchical deep features extraction techniques

Knowledge and Information Systems - The rapid increase of available data in different complex contexts needs automatic tasks to manage and process contents. Semantic Web technologies represent the...     

Laser pyrolysis in papers and patents

Journal of Intelligent Manufacturing - This paper presents a critical review of laser pyrolysis. Although this technology is almost 60 years old, in literature many researchers, both from...     

Tunable electrochemistry of gold-silver alloy nanoshells

Nano Research - The widespread and increasing interest in enhancing biosensing technologies by increasing their sensitivities and lowering their costs has led to the exploration and application of...     

Genetic effects of 1,3-butadiene and associated risk for heritable damage

A summary of the results of the studies conducted in the EU Project "Multi-endpoint analysis of genetic damage induced by 1,3-butadiene and its major metabolites in somatic and germ cells of mice, rats and man" is presented. Results of the project are summarized on the detection of DNA and hemoglobin adducts, on the cytotoxic and clastogenic effects in somatic and germinal cells of mice and rats, on the induction of somatic mutations at the hprt locus of experimental rodents and occupationally exposed workers, on the induction of dominant lethal mutations in mice and rats, and on heritable translocations induced in mice, after exposure to butadiene (BD) or its major metabolites, butadiene monoepoxide (BMO), diepoxybutane (DEB) and butadiene diolepoxide (BDE). The primary goal of this project was to collect experimental data on the genetic effects of BD in order to estimate the germ cell genetic risk to humans of exposure to BD. To achieve this, the butadiene exposure are based on data for heritable translocations and bone marrow micronuclei induced in mice and chromosome aberrations observed in lymphocytes of exposed workers. A doubling dose for heritable translocations in human germ cells of 4900 ppm/h is estimated, which, assuming cumulative BD exposure over the sensitive period of spermatogenesis, corresponds to 5-6 weeks of continuous exposure at the workplace to 20-25 ppm. Alternatively, the rate of heritable translocation induction per ppm/h of BD exposure is estimated to be approximately 0.8 per million live born, compared to a spontaneous incidence of balanced translocations in humans of approximately 800 per million live born. These estimates have large confidence intervals and are only intended to indicate orders of magnitude of human genetic risk. These risk estimates are based on data from germ cells of BD-exposed male mice. The demonstration that clastogenic damage was induced by DEB in preovulatory oocytes at doses which were not ovotoxic implies that additional studies on the response of mammalian female germ cells to BD and its metabolites are needed. The basic assumption of the above genetic risk estimates is that experimental mouse data obtained after BD exposure can be extrapolated to humans. Several points exist in the present report and in the literature which contradict this assumption: (1) the level of BMO-hemoglobin adducts was significantly elevated in BD-exposed workers; however, it was considerably lower than would have been predicted from comparable rat and mouse exposures; (2) the concentrations of the metabolites DEB and BMO were significantly higher in mouse than in rat blood after BD exposure. Thus, while metabolism of BD is qualitatively similar in the two species, it is quantitatively different; (3) no increase of HPRT mutations was shown in 19 workers exposed on average to 1.8 ppm of BD, while in a different population of workers from a US plant exposed on average to 3.5 ppm of BD, a significant increase of HPRT variants was detected; and (4) data from cancer bioassays and cancer epidemiology suggest that rat is a more appropriate model than mouse for human cancer risk from BD exposure. However, the dominant lethal study in rats gave a negative result. At present, we do not know which BD metabolite(s) may be responsible for the genetic effects even though the bifunctional alkylating agent DEB is the most likely candidate for the induction of clastogenic events. Unfortunately, methods to measure DEB adducts in hemoglobin or DNA are only presently being developed. Despite these several uncertainties the use of the mouse genetic data is regarded as a justifiable and conservative approach to human genetic risk estimation given the considerable heterogeneity observed in the biotransformation of BD in humans.     

Numerical simulation of steady planar die swell for a Newtonian fluid using the spectral element method

This paper is concerned with two dimensional numerical simulations of plane extrusion of a Newtonian fluid. The problem is discretized using the spectral element method and the free surface is evolved according to an ALE treatment. Numerical simulations are performed over a wide range of Reynolds and Weber numbers to highlight the effects of inertia and surface tension, respectively. Convergence of the numerical approximations with respect to polynomial order is demonstrated for the sensitive measures of free surface location and downstream relaxation distance. The higher the inertia the further downstream the relaxation occurs. Numerical results show good qualitative and quantitative agreement with predictions of other numerical schemes and experiments.     

Path dependent stochastic models to detect planned and actual technology use: A case study of OpenOffice

Context

Adopting IT innovation in organizations is a complex decision process driven by technical, social and economic issues. Thus, those organizations that decide to adopt innovation take a decision of uncertain success of implementation, as the actual use of a new technology might not be the one expected. The misalignment between planned and effective use of innovation is called assimilation gap.

Objective

This research aims at defining a quantitative instrument for measuring the assimilation gap and applying it to the case of the adoption of OSS.

Method

In this paper, we use the theory of path dependence and increasing returns of Arthur. In particular, we model the use of software applications (planned or actual) by stochastic processes defined by the daily amounts of files created with the applications. We quantify the assimilation gap by comparing the resulting models by measures of proximity.

Results

We apply and validate our method to a real case study of introduction of OpenOffice. We have found a gap between the planned and the effective use despite well-defined directives to use the new OS technology. These findings suggest a need of strategy re-calibration that takes into account environmental factors and individual attitudes.

Conclusions

The theory of path dependence is a valid instrument to model the assimilation gap provided information on strategy toward innovation and quantitative data on actual use are available.     

A hybrid positioning system for technology‐independent location‐aware computing

Location‐aware computing is a form of context‐aware mobile computing that refers to the ability of providing users with services that depend on their position. Locating the user terminal, often called positioning, is essential in this form of computing. Towards this aim, several technologies exist, ranging from personal area networking, to indoor, outdoor, and up to geographic area systems. Developers of location‐aware software applications have to face with a number of design choices, that typically depend on the chosen technology. This work addresses the problem of easing the development of pull location‐aware applications, by allowing uniform access to multiple heterogeneous positioning systems. Towards this aim, the paper proposes an approach to structure location‐aware mobile computing systems in a way independent of positioning technologies. The approach consists in structuring the system into a layered architecture, that provides application developers with a standard Java Application Programming Interface (JSR‐179 API), and encapsulates location data management and technology‐specific positioning subsystems into lower layers with clear interfaces. In order to demonstrate the proposed approach we present the development of HyLocSys. It is an open hybrid software architecture designed to support indoor/outdoor applications, which allows the uniform (combined or separate) use of several positioning technologies. HyLocSys uses a hybrid data model, which allows the integration of different location information representations (using symbolic and geometric coordinates). Moreover, it allows support to handset‐ and infrastructure‐based positioning approaches while respecting the privacy of the user. The paper presents a prototypal implementation of HyLocSys for heterogeneous scenarios. It has been implemented and tested on several platforms and mobile devices. Copyright © 2009 John Wiley & Sons, Ltd.     

An Introduction to Using XML for the Management of Laboratory Data

Extensible Markup Language (XML) and the XML Path Language (XPath) are introduced with software examples demonstrating how one can use them to write laboratory data management programs. Topics explored include XML document creation, manipulation, and searching. Programming examples make use of the Microsoft® XML Parser library and the Visual Basic programming language. The problem of managing microplate screening data is used as an illustration. Source code for all examples can be downloaded from http://www.labprogrammer.net.