Transgenic overproduction of islet amyloid polypeptide (amylin) is not sufficient for islet amyloid formation

Islet amyloid polypeptide forms islet amyloid deposits in non-insulin-dependent diabetes mellitus. We have generated transgenic mice which express human islet amyloid polypeptide in their pancreatic beta cells yet do not develop islet amyloid deposits despite producing levels of the amyloidogenic human peptide 2 - 3 fold higher than the native (mouse) peptide. To determine whether marked overproduction of islet amyloid polypeptide is a potential cause of islet amyloid formation, we increased expression of this transgene by producing homozygous transgenic animals and by making heterozygous mice experimentally insulin resistant with nicotinic acid. Pancreatic content of islet amyloid polypeptide-like immunoreactivity in homozygous and nicotinic acid-treated mice was 2-fold (25 +/- 7 fmol/microg; n = 6) and 3.5-fold (47 +/- 20 fmol/microg; n = 3) higher, respectively, than that of untreated heterozygous animals (13+/-2 fmol/microg; n = 11; both p < 0.05). Despite this marked increase in production of islet amyloid polypeptide, neither group of mice developed gross islet amyloid deposits even after 16 months of age. We conclude that overproduction of islet amyloid polypeptide, even as produced by extreme insulin resistance, is not in itself sufficient for islet amyloid formation.     

油酸乙二醇单酯在基础油与水界面上形成吸附膜的研究

以油酸和乙二醇为原料，在酸性催化剂作用下，用硼酸间接酯化法合成了润滑油油性油酸乙二醇单酯，用界面张力仪测定了单酯含量的矿物油的界面张力。用量小二乘法求得油中油酸乙二醇单脂的浓度与油对水界面张力关系的回归方程。依据所求的回归方程和Ｇｉｂｂｓ公式计算出油酸乙二醇单脂在油与水界面上形成吸附膜时的最低浓度。     

大坝施工混凝土质量的评价体系

本文介绍了大坝施工混凝土质量的评价系统软件的设计思路和设计成果。它利用现代计算机技术和应用模糊数学理论评价混凝土重力坝和拱坝单块和整体的质量。在采用模糊综合评价工程质量中，对不同工艺环节，对坝体不同部位，鉴于其质量要求的差异应赋予不同的权重，在权重的取值上采用了专家调查排序，定量转化的方法是比较适宜的。在程序设计中，评价数学模型采用了BASIC程序，访膜块通过*TXT文件实现了与整个大坝混凝土质量微机管理系统的接口及数据传递。操作运行方便灵活。     

湿敏半导体材料电导率计算方法的研究

结合修正了的耗尽层理论和多孔湿敏半导体的特点，本文提出了一个简单的物理模型作为ｎ型湿敏半导体特征的一级近似。描述了多孔湿敏半导体的导电机理，并给出了湿度与宏观电导率的关系。     

面向对象系统中的特性表机制与复合对象

本文主要讨论特性表机制与复合对象的概念、功能及实现．在基于知识的面向对象系统中引入特性表机制与复合对象概念的目的在于增强系统的知识表达能力．文中提出的特性表机制包括了三种类型的特性说明表：类说明特性表、继承关系特性表和变量特性说明表．复合对象在系统中是通过引入一个称为“影子类”的新概念来构造和实现的．     

A rapid dot-blot method for species identification of bloodstains

A very simple and rapid test for species identification is reported. Extracts of bloodstains were applied to a synthetic porous membrane and dried. The membrane was then quenched with glycine buffered saline containing BSA and Tween 20. A suspension of colloidal gold particles (GP) coated with rabbit antiserum to human IgG was poured onto, gently whirled and aspirated through the membrane. Spots from the human and monkey bloodstains became red, whereas those from other species of animals remained unstained. This test was completed within 3 to 4 min, and the antibody-coated GP reagent was prepared within 20 min using a very small quantity of antiserum. Cellulose acetate membranes of 0.45 microns or more in pore size were appropriate to this test.     

泥浆制备中工艺改造的研究

根据室条件下粉磨试验结果，发现球磨过程中筛上料变化存在的突变范围，提出两次加料一次加水可改变泥浆颗粒分布，并找出适宜的加料种类与时间。另外给予测粒度分布提供了宝贵的试验基础数据。     

基于IGBT的PWM大功率直流伺服驱动

本文介绍ＩＧＢＴ、ＥＸＢ８４１和ＬＥＭ模块在大功率ＰＷＭ直流伺服驱动系统中的应用和系统抗干扰设计。使用效果表明，基于ＩＧＢＴ的设计，可提高大功率直流伺服系统的可靠性和性能、减小体积、降低成本。     

阜阳电厂粉煤灰综合利用可行性研究

结合阜阳地区实际情况，从目前成熟的粉煤灰利用途径中，选择制水泥、建粉磨站、生产非煅烧粉煤灰轻骨料、轻质小砌块，以及筑路回填、灰场种植等处理利用项目，达到节约土地并获得好的经济效益和环境效益