Dynamic Studies On Human Body Sway By Using A Simple Model With Special Concerns On The Pelvic And Muscle Roles

The human pelvis is such a unique structure that enables our upper body to work so perfectly with the two legs so as to control the body's balance in the complicated postures. The aim of this study is to establish a new dynamic body sway control model in the upright standing body position in coronal plane, and to reveal the possible control mechanisms underlying the body sway with special concerns on the roles that the pelvis and its muscles are performing during the sway. The plant of control model, the dynamics of human body, includes five parts, i.e. two ankles, two hips and one lumbosacral joint, which makes up a multi‐link inverted pendulum system, and is driven by two pairs of muscles, the psoas major (PM) and glutaeus medius (GM). Body sway records from eight healthy young subjects showed that the angular sway scopes of the ankle on roll (lateral) plane are 0.94±0.36± (eye‐open) and 1.35±0.52± (eye‐closed) respectively, while in lumbosacral plane, the scopes are 0.99±0.41± (eye‐open) and 1.27±0.72± (eye‐closed). The ankle and lumbosacral sways were almost in the same degree, yet their phase difference was near ±n, which means that the body trunk maintains perpendicular to horizon during the upright stance. Surface electromyographic (sEMG) activity from GM also showed the same evidence: the activated GM was always in the same side as the deviated center‐of‐pressure (COP). By assuming the corrective torque of posture is regulated by PID (proportional, integral and derivative) control, the body sway can be simulated by applying human physical parameters. Our study results demonstrated that the simulated traces are consistent with the experimental recorded, suggesting that the pelvis is an important structure for the posture maintenance and control, and the mechanism of balance keeping control during upright stance can be approximately taken as a PID control. The result also suggests a novel means for postural stability assessment in individual in the future.     

Concomitant activation of MEK-1 and Rac-1 increases the proliferative potential of thyroid epithelial cells, without affecting their differentiation

Activating point mutations in the Ras oncogene occur in a large number of human tumors, especially of epithelial origin. In thyroid follicular cells, ectopic expression of oncogenic H-Ras results in growth factor-independent proliferation, loss of differentiation and tumor formation in nude mice. In fibroblasts concomitant activation of the MAP kinase cascade and the small GTPase Rac-1 leads to full malignant transformation. We have tested the effects of these key downstream mediators of Ras in thyroid epithelial cells, by stably expressing either a constitutively active form of MEK-1 (MEK(deltaN3/S218E/S222D)), a constitutively active form of Rac-1 (Val12-Rac), or both. While the activation of one molecule or the other results in a weak phenotype, concomitant activation of both MEK-1 and Rac-1 in thyroid cells leads to growth factor-independent proliferation, morphological transformation and anchorage-independent growth. However, in contrast to Ras-transformed thyroid cells, the ones expressing the constitutively active forms of MEK-1 and Rac-1 maintain their differentiate phenotype and fail to form tumors when injected into nude mice. Thus, in thyroid epithelial cells, concomitant activation of MEK-1 and Rac-1 can reproduce only a subset of the Ras-induced effects and is not sufficient to cause full malignant transformation. Significantly, Ras-mediated increased proliferation and loss of differentiation can be dissociated in these cells.     

担载型含稀土三组份体系在二氧化碳甲烷化反应中的催化性能

用浸渍法制备了一系列氧化锆担载的含稀土Ⅷ族金属催化剂，对其在二氧化碳甲烷化过程中的催化活性作了研究，并用漫反射紫外可见光谱，ＦＴＩＲ等手段对催化剂作了表征。结果表明，含稀土新型催化剂具有催化活性高，目标产物选择性好等优点；稀土主要以氧化物形式存在于催化剂表面，参与对氢及表面含碳物种的吸附及活化；含稀土三组份催化剂的活性与所添加稀土三价离子的４ｆ电子数有关。     

Thermodynamics of inositol hexakisphosphate interaction with human oxyhemoglobin

The interaction of inositol hexakisphosphate (IHP) with oxygenated human adult hemoglobin (Hb) was investigated at 25 degreesC. The affinity of IHP for oxygenated Hb is strongly pH-dependent, and potentiometric measurements of proton uptake and release upon IHP addition have shown that over the range between pH 8.0 and pH 6.0 in oxygenated Hb there are three groups of residues that change their pKa values after IHP addition, likely because of their interaction with negative charges of the heterotropic effector. On the basis of previous calculations on the electrostatic properties of human Hb (Matthew, J. B., Hanania, G. I. H., and Gurd, F. R. N. (1979) Biochemistry 18, 1919-1928; Lee, A. W.-m., Karplus, M., Poyart, C., and Bursaux, E. (1988) Biochemistry 27, 1285-1301), two of these groups might be Val1beta and His143beta, which are located in the beta1beta2 dyad axis, where they have been also proposed to interact with 2,3-diphosphoglycerate, whereas the third group does not appear easily identifiable. Calorimetric measurements of the heat associated with IHP binding at different pH values over the same range indicate that IHP binding is mostly enthalpy-driven at pH < 7 and mostly entropy-driven at pH > 7.     

直流电弧炉长弧泡沫渣技术

本文指出了直流电弧炉采用长弧泡沫渣技术的必要性及该技术的发展现状，总结了炉渣物理性质，化学成分，温度和气源等对炉渣泡沫化的影响，并介绍了电炉泡沫渣的操作工艺及实际应用效果，对宝钢三期１５０ｔＤＣ－ＵＨＰ电弧炉的泡沫渣工艺提出了看法。     

Necessary conditions for asymptotic tracking in nonlinear systems

In the literature, it has been shown that if a single-input single-output analytic nonlinear plant 1) has a well-defined relative degree and 2) is minimum-phase, it is possible to achieve asymptotic tracking for an open set of output trajectories containing the origin in C^N [0, ∞), the space of N-times continuously differentiable functions taking values in R. When either of these sufficient conditions is not met, various authors have investigated approximate analytic solutions, discontinuous solutions and solutions for restricted sets of trajectories. In this paper, it is shown that conditions 1) and 2) are necessary for the existence of an analytic compensator which yields asymptotic tracking for an open set of output trajectories. Analogous results are established for multi-input multi-output systems     

Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry

Gonadal differentiation involves a complex interplay of developmental pathways. The sex determining region Y (SRY) gene plays a key role in testis determination, but its interaction with other genes is less well understood. Abnormalities of gonadal differentiation result in a range of clinical problems. 46,XY complete gonadal dysgenesis is defined by an absence of testis determination. Subjects have female external genitalia and come to clinical attention because of delayed puberty. Individuals with 46,XY partial gonadal dysgenesis usually present in the newborn period for the valuation of ambiguous genitalia. Gonadal histology always shows an abnormality of seminiferous tubule formation. A diagnosis of 46,XY true hermaphroditism is made if the gonads contain well-formed testicular and ovarian elements. Despite the pivotal role of the SRY gene in testis development, mutations of SRY are unusual in subjects with a 46,XY karyotype and abnormal gonadal development. 46,XX maleness is defined by testis determination in an individual with a 46,XX karyotype. Most affected individuals have a phenotype similar to that of Klinefelter syndrome. In contrast, subjects with 46,XX true hermaphroditism usually present with ambiguous genitalia. The majority of subjects with 46,XX maleness have Y sequences including SRY in genomic DNA. However, only rare subjects with 46,XX true hermaphroditism have translocated sequences encoding SRY. Mosaicism and chimaerism involving the Y chromosome can also be associated with abnormal gonadal development. However, the vast majority of subjects with 45,X/46,XY mosaicism have normal testes and normal male external genitalia.     

On dissipation induced by phase transformations

Summary Motions of hyperelastic materials involving surfaces of strain or stress discontinuities are generally dissipative in the sense that, in any portion of the body that is traversed by a moving singular surface, the rate of work of the external forces differs from the rate of storage of the total energy (the strain energy and the kinetic energy) by the rate of work done in moving the singular surface. Hence, the corresponding continuum theory is capable of modeling dissipative behavior associated with phase transformations which has potential applications in the design ofadaptive structures. The present work indicates that this dissipative behavior is characterized by a material function, called the driving-traction-response function, which is uniquely determined by the strain energy potential of the material. The driving-traction-response function vanishes identically if and only if the Piola-Kirchhoff stress-response function depends upon the deformation gradient linearly.