基于软件接收机的GPS信号快速捕获算法

针对GPS信号C/A码的捕获,利用多项式拟合估计多普勒频率偏移值,减少了频率搜索范围;将直接求相关值和利用FFT/IFFT变换的算法相结合,用于确定C/A码相位。且在信号处理上利用抽取避免重复采样。仿真结果表明,该算法在同等的定位精度要求下,降低了计算复杂度,提高了C/A码的捕获速度。     

Ex-post efficient resource allocation for Self-organizing Cloud

Self-organizing Cloud is a scalable model to provide powerful computability with distributed computers. The resource allocation on it is very challenging since it not only involves various types of divisible resources but needs to cope with social competitions. We propose a novel resource allocation scheme with three features on ex-post efficiency. (1) Ex-post win–win effect: each participant (consumers and suppliers) should always feel satisfied with their ex-post payoffs. (2) Incentive compatibility: we can prove each rational participant gets its optimal payoff iff their resource demands and expected prices are truthfully declared. (3) Ex-post maximized efficiency: more powerful resources should be consumed with higher likelihood, such that the whole system runs quite efficiently with maximized resource utilization. Our simulation shows the approach significantly improves resource suppliers’ incomes by 20% compared to their expectations. Meanwhile, we can guarantee consumers’ payments below their budgets, with no any degradation of task execution performance.     

基于自动区域模型的含分布式电源配电网可靠性评估

提出了一种基于含分布式电源的配电块的简化网络可靠性FMEA算法。根据不同开关的功能,以自动开关装置为边界形成自动区域,将含分布式电源的配电网络简化为只含开关、配电块、负荷以及分布式电源的等效网络,每个自动区域仅含一个自动开关和若干个手动开关,由自动区域特性可知:与主区域直接相连的所有支路的负荷点有相同的故障率,且该类负荷点的故障停运时间由系统元件故障位置来确定;与支路区域相连的负荷点的故障率不受主区域的影响,且该类负荷点的故障停运时间由分布式电源所在支路区域的相对位置来确定。基于配电块的故障模式后果分析法,提出了形式化的含分布式电源的配电网络可靠性评估算法。该算法在很大程度上减少了重复枚举的数量,通过RBTS算例分析,证明了该方法的有效性。     

The working mechanism of organic photovoltaic cell by using copper phthalocyanine as exciton blocking layer

We demonstrate the working mechanism of organic photovoltaic (OPV) cell with copper phthalocyanine (CuPc) as exciton blocking layer (EBL). The new EBL material CuPc, commonly has been used as electron donor in the organic solar cells due to its electron-donating and hole-transporting properties. But here we proves that the α-polymorph CuPc layer can transfer electrons to Al cathode through the half-filled b_1g level, this mechanism is different from that of general EBL material with larger band gap and electron-transporting property, which is based on damage states induced by the heat of evaporating Al.     

Inhibitors of Mitochondrial Human Carbonic Anhydrases VA and VB as a Therapeutic Strategy against Paclitaxel-Induced Neuropathic Pain in Mice

Neuropathy development is a major dose-limiting side effect of anticancer treatments that significantly reduces patient’s quality of life. The inadequate pharmacological approaches for neuropathic pain management warrant the identification of novel therapeutic targets. Mitochondrial dysfunctions that lead to reactive oxygen species (ROS) increase, cytosolic Ca²⁺ imbalance, and lactate acidosis are implicated in neuropathic pain pathogenesis. It has been observed that in these deregulations, a pivotal role is played by the mitochondrial carbonic anhydrases (CA) VA and VB isoforms. Hence, preclinical studies should be conducted to assess the efficacy of two novel selenides bearing benzenesulfonamide moieties, named 5b and 5d, and able to inhibit CA VA and VB against paclitaxel-induced neurotoxicity in mice. Acute treatment with 5b and 5d (30–100 mg/kg, per os – p.o.) determined a dose-dependent and long-lasting anti-hyperalgesic effect in the Cold plate test. Further, repeated daily treatment for 15 days with 100 mg/kg of both compounds (starting the first day of paclitaxel injection) significantly prevented neuropathic pain development without the onset of tolerance to the anti-hyperalgesic effect. In both experiments, acetazolamide (AAZ, 100 mg/kg, p.o.) used as the reference drug was partially active. Moreover, ex vivo analysis demonstrated the efficacy of 5b and 5d repeated treatments in reducing the maladaptive plasticity that occurs to glia cells in the lumbar portion of the spinal cord and in improving mitochondrial functions in the brain and spinal cord that were strongly impaired by paclitaxel-repeated treatment. In this regard, 5b and 5d ameliorated the metabolic activity, as observed by the increase in citrate synthase activity, and preserved an optimal mitochondrial membrane potential (ΔΨ) value, which appeared depolarized in brains from paclitaxel-treated animals. In conclusion, 5b and 5d have therapeutic and protective effects against paclitaxel-induced neuropathy without tolerance development. Moreover, 5b and 5d reduced glial cell activation and mitochondrial dysfunction in the central nervous system, being a promising candidate for the management of neuropathic pain and neurotoxicity evoked by chemotherapeutic drugs.     

Immobilization of Lathyrus cicera Amine Oxidase on Magnetic Microparticles for Biocatalytic Applications

Amine oxidases are enzymes belonging to the class of oxidoreductases that are widespread, from bacteria to humans. The amine oxidase from Lathyrus cicera has recently appeared in the landscape of biocatalysis, showing good potential in the green synthesis of aldehydes. This enzyme catalyzes the oxidative deamination of a wide range of primary amines into the corresponding aldehydes but its use as a biocatalyst is challenging due to the possible inactivation that might occur at high product concentrations. Here, we show that the enzyme’s performance can be greatly improved by immobilization on solid supports. The best results are achieved using amino-functionalized magnetic microparticles: the immobilized enzyme retains its activity, greatly improves its thermostability (4 h at 75 °C), and can be recycled up to 8 times with a set of aromatic ethylamines. After the last reaction cycle, the overall conversion is about 90% for all tested substrates, with an aldehyde production ranging between 100 and 270 mg depending on the substrate used. As a proof concept, one of the aldehydes thus produced was successfully used for the biomimetic synthesis of a non-natural benzylisoquinoline alkaloid.     

NSCLC as the Paradigm of Precision Medicine at Its Finest: The Rise of New Druggable Molecular Targets for Advanced Disease

Standard treatment for advanced non-small cell lung cancer (NSCLC) historically consisted of systemic cytotoxic chemotherapy until the early 2000s, when precision medicine led to a revolutionary change in the therapeutic scenario. The identification of oncogenic driver mutations in EGFR, ALK and ROS1 rearrangements identified a subset of patients who largely benefit from targeted agents. However, since the proportion of patients with druggable alterations represents a minority, the discovery of new potential driver mutations is still an urgent clinical need. We provide a comprehensive review of the emerging molecular targets in NSCLC and their applications in the advanced setting.     

Chronic Hyperkaliemia in Chronic Kidney Disease: An Old Concern with New Answers

Increasing potassium intake ameliorates blood pressure (BP) and cardiovascular (CV) prognoses in the general population; therefore the World Health Organization recommends a high-potassium diet (90–120 mEq/day). Hyperkalaemia is a rare condition in healthy individuals due to the ability of the kidneys to effectively excrete dietary potassium load in urine, while an increase in serum K⁺ is prevalent in patients with chronic kidney disease (CKD). Hyperkalaemia prevalence increases in more advanced CKD stages, and is associated with a poor prognosis. This scenario generates controversy on the correct nutritional approach to hyperkalaemia in CKD patients, considering the unproven link between potassium intake and serum K⁺ levels. Another concern is that drug-induced hyperkalaemia leads to the down-titration or withdrawal of renin-angiotensin system inhibitors (RASI) and mineralocorticoids receptors antagonists (MRA) in patients with CKD, depriving these patients of central therapeutic interventions aimed at delaying CKD progression and decreasing CV mortality. The new K⁺-binder drugs (Patiromer and Sodium-Zirconium Cyclosilicate) have proven to be adequate and safe therapeutic options to control serum K⁺ in CKD patients, enabling RASI and MRA therapy, and possibly, a more liberal intake of fruit and vegetables.     

Localization-limited exciton oscillator strength in colloidal CdSe nanoplatelets revealed by the optically induced stark effect

2D materials are considered for applications that require strong light-matter interaction because of the apparently giant oscillator strength of the exciton tra...