穿越黑色时空的光影世界——间离剧

正一家在上海创办的建筑与室内设计事务所,致力于根据客户的需求制定美观新颖的空间解决方案。我们对概念的艺术性和施工的工艺同样重视。每个项目都根据其环境和条件量身定做,并在有限的造价和时间里做出最好的效果。来到这个剧院的观众,都是自己这出戏的演员和导演。间离剧以独特的形态,为观众提供了别具一格     

[2.2]Paracyclophane-Based TCN-201 Analogs as GluN2A-Selective NMDA Receptor Antagonists

Recent studies have shown the involvement of GluN2A subunit-containing NMDA receptors in various neurological and pathological disorders. In the X-ray crystal structure, TCN-201 ( 1 ) and analogous pyrazine derivatives 2 and 3 adopt a U-shape (hairpin) conformation within the binding site formed by the ligand binding domains of the GluN1 and GluN2A subunits. In order to mimic the resulting π/π-interactions of two aromatic rings in the binding site, a [2.2]paracyclophane system was designed to lock these aromatic rings in a parallel orientation. Acylation of [2.2]paracyclophane ( 5 ) with oxalyl chloride and chloroacetyl chloride and subsequent transformations led to the oxalamide 7 , triazole 10 and benzamides 12 . The GluN2A inhibitory activities of the paracyclophane derivatives were tested with two-electrode voltage clamp electrophysiology using Xenopus laevis oocytes expressing selectively functional NMDA receptors with GluN2A subunit. The o-iodobenzamide 12 b with the highest similarity to TCN-201 showed the highest GuN2A inhibitory activity of this series of compounds. At a concentration of 10 μM, 12 b reached 36 % of the inhibitory activity of TCN-201 ( 1 ). This result indicates that the [2.2]paracyclophane system is well accepted by the TCN-201 binding site.     

Application of energy efficient soft-decision error control in wireless sensor networks

Energy efficient reliable communication over an unpredictable wireless medium is a major challenge for resource constrained wireless sensor nodes in process/environment control application. In this paper, we propose a Soft Decision Decoding (SDD) based advanced Forward Error Correction (FEC) scheme for low power distributed sensor nodes. The proposed BCH (Bose-Chaudhuri-Hocquenghem) based adaptive Chase-2 decoding scheme offers attractive energy benefits as compared to Hard Decision Decoding (HDD). The reduced decoding complexity is obtained by limiting the codeword search space and fewer algebraic operations compared to standard Chase-2. A realistic environmental scenario incorporating path loss, Rayleigh fading and Additive White Gaussian Noise has been considered to investigate the performance of the proposed scheme. A detailed comparison is carried out with HDD of BCH codes using the widely known Crossbow MicaZ node parameters. The simulation results indicate that for low power WSN, the proposed SDD based adaptive scheme offers better tradeoff between energy and reliability than HDD schemes.     

Innovation Subsidies: Does the Funding Source Matter for Innovation Intensity and Performance? Empirical Evidence from Germany

In this paper we analyze the effect of European and national funding on innovation input and output at the firm level. In terms of innovation input, we do not find evidence that one policy crowds out the effect of the other. Instead, the policies are complements. In terms of output, we find that subsidy recipients are more active with respect to patenting. A citation analysis of patents reveals that the subsidy recipients file patents that are more valuable (in terms of forward citations) than those filed in the counterfactual situation of receiving no public support. These results suggest that public funding triggers socially beneficial research projects and that the co-existence of national and European policies does not lead to crowding-out effects when compared to a hypothetical world of a closed economy with no supplemental European policies.     

Modellbasierte Entscheidungsunterstützung in Produktions- und Dienstleistungsnetzwerken

In this paper, we sketch some of the challenges that should be addressed in future research efforts for model-based decision support in manufacturing and service networks. This includes integration issues, taking into account the autonomy of the decision-making entities in face of information asymmetry, the modeling of preferences of the decision-makers, efficiently determining robust solutions, i.e. solutions that are insensitive with respect to changes in the problem data, and a reduction of the time needed for model building and usage. The problem solution cycle includes problem analysis, the design of appropriate algorithms and their performance assessment. We are interested in a prototypical integration of the proposed methods within application systems, which can be followed up with field tests of the extended application systems. We argue that the described research agenda requires the interdisciplinary collaboration of business and information systems engineering researchers with colleagues from management science, computer science, and operations research. In addition, we present some exemplifying, illustrative examples of relevant research results.     

Take care of your belongings today – securing accessibility to complex electronic business processes

Most of today’s business processes are based solely on digital data. Input, output, and intermediate results are pure digital objects. Keeping such data accessible and meaningful but even more importantly keeping the business processes functional is challenging. With regards to complex electronic business processes traditional archiving does not provide satisfactory results. Due to the fast technical life-cycle the time gap between archiving and re-enactment or reuse of a process poses risks and increases the uncertainty on achievable results. We propose a novel strategy bridging this specific time gap. For this we present a scalable and cost-effective infrastructure with associated workflows focusing on a process’ execution context. Most importantly the process’ developers are able to assess the preserved results in a timely manner, and thus, reduce the uncertainty on future re-enactment results.