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排序方式: 共有820条查询结果,搜索用时 349 毫秒
31.
Dr. Rosaria Ciriminna Dr. Alexandra Fidalgo Dr. Francesco Meneguzzo Dr. Alessandro Presentato Dr. Antonino Scurria Dr. Domenico Nuzzo Prof. Rosa Alduina Prof. Laura M. Ilharco Dr. Mario Pagliaro 《ChemMedChem》2020,15(23):2228-2235
First reported in the late 1930s and partly explained in 1970, the antibacterial activity of pectin remained almost ignored until the late 1990s. The concomitant emergence of research on natural antibacterials and new usages of pectin polysaccharides, including those in medicine widely researched in Russia, has led to a renaissance of research into the physiological properties of this uniquely versatile polysaccharide ubiquitous in plants and fruits. By collecting scattered information, this study provides an updated overview of the subtle factors affecting the behaviour of pectin as an antimicrobial. Less-degraded pectin extracted by acid-free routes, we argue in the conclusions, will soon find applications from new treatments for polymicrobial infections to use as an implantable biomaterial in tissue and bone engineering. 相似文献
32.
Dr. Jessica Ceramella Dr. Annaluisa Mariconda Dr. Camillo Rosano Dr. Domenico Iacopetta Dr. Anna Caruso Prof. Pasquale Longo Prof. Maria Stefania Sinicropi Prof. Carmela Saturnino 《ChemMedChem》2020,15(23):2306-2316
Cancer is going to be the first cause of mortality worldwide in the 21th century. It is considered a multifactorial disease that results from the combined influence of many genetic aberrations, leading to abnormal cell proliferation. As microtubules are strongly implicated in cellular growth, they represent an important target for cancer treatment. The well-known microtubule-targeting agents (MTAs) including paclitaxel, colchicine and vinca alkaloids are commonly used in the treatment of various cancers. However, adverse effects and drug resistance are major limitations in their clinical use. To find new candidates able to induce microtubule alteration with reduced toxic effects or drug resistance, we studied a small new series of derivatives that present imidazolinic, guanidinic, thioureidic and hydrazinic groups ( 1 – 9 ). All the compounds were tested for their antitumor activity against a panel of six tumoral cell models. In particular, compound 8 (nonane-1,9-diyl-bis-S-amidinothiourea dihydrobromide) showed the lowest IC50 value against HeLa cells, together with a low cytotoxicity for normal cells. This compound was able to induce the apoptotic mitochondrial pathway and inhibited tubulin polymerization with a similar efficacy to vinblastine and nocodazole. Taken together, these promising biological properties make compound 8 useful for the development of novel therapeutic approaches in cancer treatment. 相似文献
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Annurca (Malus pumila Miller cv. Annurca) apple as a functional food for the contribution to a healthy balance of plasma cholesterol levels: results of a randomized clinical trial 下载免费PDF全文
35.
Scherm B Palomba M Serra D Marcello A Migheli Q 《International journal of food microbiology》2005,98(2):201-210
36.
Experimental exchange rates for Cl-/SO=4 exchange on strictly comparable anion resins in 0.006N solution confirm the unfavorable correlation between kinetics and selectivity.Furthermore, evaluation of the influence of other physico-chemical properties of the resins (i.e., nature of matrix, type of amine, etc) seems to support the hypothesis that chemical interactions, and not only diffusional effects, in the resin phase play a leading role on rate control. 相似文献
37.
Francesca Biagioni Federica Mastroiacovo Paola Lenzi Stefano Puglisi-Allegra Carla L. Busceti Larisa Ryskalin Rosangela Ferese Domenico Bucci Alessandro Frati Ferdinando Nicoletti Francesco Fornai 《International journal of molecular sciences》2021,22(19)
The peri-infarct region, which surrounds the irreversible ischemic stroke area is named ischemic penumbra. This term emphasizes the borderline conditions for neurons placed within such a critical region. Area penumbra separates the ischemic core, where frank cell loss occurs, from the surrounding healthy brain tissue. Within such a brain region, nervous matter, and mostly neurons are impaired concerning metabolic conditions. The classic biochemical marker, which reliably marks area penumbra is the over-expression of the heat shock protein 70 (HSP70). However, other proteins related to cell clearing pathways are modified within area penumbra. Among these, autophagy proteins like LC3 increase in a way, which recapitulates Hsp70. In contrast, components, such as P20S, markedly decrease. Despite apparent discrepancies, the present study indicates remarkable overlapping between LC3 and P20S redistribution within area penumbra. In fact, the amount of both proteins is markedly reduced within vacuoles. Specifically, a massive loss of LC3 + P20S immuno-positive vacuoles (autophagoproteasomes) is reported here. This represents the most relevant sub-cellular alteration here described in cell clearing pathways within area penumbra. The functional significance of these findings remains to be determined and it will take a novel experimental stream to decipher the fine-tuning of such a phenomenon. 相似文献
38.
Thermophiles as Potential Source of Novel Endotoxin Antagonists: the Full Structure and Bioactivity of theLipo‐oligosaccharide from Thermomonas hydrothermalis 下载免费PDF全文
Dr. Flaviana Di Lorenzo Dr. Ida Paciello Dr. Luigi Lembo Fazio Dr. Luciana Albuquerque Dr. Luisa Sturiale Prof. Milton S. da Costa Prof. Rosa Lanzetta Prof. Michelangelo Parrilli Prof. Domenico Garozzo Prof. Maria Lina Bernardini Dott. Alba Silipo Prof. Antonio Molinaro 《Chembiochem : a European journal of chemical biology》2014,15(14):2146-2155
Thermomonas hydrothermalis is a Gram‐negative thermophilic bacterium that is able to live at 50 °C. This ability is attributed to chemical modifications, involving those to bacterial cell‐wall components, such as proteins and (glyco)lipids. As the main component of the outer membrane of Gram‐negative bacteria, lipopolysaccharides (LPSs) are exposed to the environment, thus they can undergo structural chemical changes to allow thermophilic bacteria to live at their optimal growth temperature. Furthermore, as one of the major target of the eukaryotic innate immune system, LPS elicits host immune response in a structure‐dependent mode; thus the uncommon chemical features of thermophilic bacterial LPSs might exert a different biological action on the innate immune system—an antagonistic effect, as shown in studies of LPS structure–activity relationship in the ongoing research into antagonist LPS candidates. Here, we report the complete structural and biological activity analysis of the lipo‐oligosaccharide isolated from Thermomonas hydrothermalis, achieved by a multidisciplinary approach (chemical analysis, NMR, MALDI MS and cellular immunology). We demonstrate a tricky and interesting structure combined with a very interesting effect on human innate immunity. 相似文献
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Simone Ceriani Giulio Fontana Alessandro Giusti Daniele Marzorati Matteo Matteucci Davide Migliore Davide Rizzi Domenico G. Sorrenti Pierluigi Taddei 《Autonomous Robots》2009,27(4):353-371
A trustable and accurate ground truth is a key requirement for benchmarking self-localization and mapping algorithms; on the
other hand, collection of ground truth is a complex and daunting task, and its validation is a challenging issue. In this
paper we propose two techniques for indoor ground truth collection, developed in the framework of the European project Rawseeds, which are mutually independent and also independent on the sensors onboard the robot. These techniques are based, respectively,
on a network of fixed cameras, and on a network of fixed laser scanners. We show how these systems are implemented and deployed,
and, most importantly, we evaluate their performance; moreover, we investigate the possible fusion of their outputs. 相似文献