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31.
While the concept of policy integration is not a new idea within spatial planning discourse, it is becoming increasingly prevalent. Frequently, however, the term is used without any clear definition of what it means, or how it might be achieved. The aim of this paper is to provide more clarity about the concept and to identify the types of actions in the field of planning where integration with policy can be improved. In so doing, the paper assembles a range of material from different disciplines, and identifies some of the key inhibitors and facilitators of policy integration. 相似文献
32.
Carolina Pinto Rebecca Ing Ben Browning Vinicius Delboni Hazel Wilson Dominic Martyn Gemma L. Harvey 《Water and Environment Journal》2019,33(3):353-365
Large wood (re)introduction can deliver multiple benefits in river restoration, but there is a dearth of the detailed and longer‐term post‐project monitoring and evaluation required for improving best practice. We present findings from an academic partnership approach to post‐project evaluation, based on successive MSc research projects on restored large wood in the Loddon catchment, UK. Field and modelling data reveal: (i) key differences in large wood features between restored and natural reaches; (ii) increased hydraulic retention and changes to mesohabitats associated with large wood; (iii) differences in macroinvertebrate community composition around large wood but a lack of site‐level effects; (iv) interactions between macrophytes and large wood that may be specific to restored reaches; (v) a need for further field and modelling studies to inform the accurate representation of large wood in hydraulic models. Some key challenges in partnership working are identified to aid planning and effectiveness of future collaborations. 相似文献
33.
Dominic Riedel Thomas Wurm Katharina Graf Matthias Rudolph Frank Rominger A. Stephen K. Hashmi 《Advanced Synthesis \u0026amp; Catalysis》2015,357(7):1515-1523
In a modular template synthesis, unsaturated NHC complexes of gold, palladium and platinum were synthesized from simple metal salts, isonitriles and amines with acetal or ketal groups. Upon the addition of amines with tethered acetal or ketal moieties to the metal‐activated isonitrile, first nitrogen acyclic carbene (NAC) complexes are formed. These undergo ring closure and elimination to the unsaturated NHC complexes upon addition of acid. This simple strategy opens an attractive and fast approach to NHC complexes of gold, palladium and platinum. The modular approach allows a fast modification and is well‐suited for the synthesis of unsymetrically and symmetrically substituted unsaturated NHC complexes.
34.
Lui Ng Sunny Kit-Man Wong Zheng Huang Colin Siu-Chi Lam Ariel Ka-Man Chow Dominic Chi-Chung Foo Oswens Siu-Hung Lo Roberta Wen-Chi Pang Wai-Lun Law 《International journal of molecular sciences》2022,23(3)
CD26 has been reported as a marker for colorectal cancer stem cells endowed with tumor-initiating properties and capable of colorectal cancer (CRC) metastasis. In this study, we investigated the functional effect of CD26 on CRC angiogenesis and metastasis, and the potential underlying mechanism. The functional effects of CD26 overexpression or repression were determined by a wound healing experiment, and cell migration and invasion assays in vitro and in mouse models. Differentially expressed genes regulated by CD26 were identified by genome-wide mRNA expression array and validated by quantitative PCR. CD26 functionally regulated CRC cell migration and invasion in vitro and angiogenesis and metastasis in vivo. Genome-wide mRNA expression array and qPCR showed that MMP1 was up-regulated in CD26+ subpopulation, and a subsequent experiment demonstrated the regulatory effect of CD26 on MMP1 in CRC cell lines with CD26 repression or overexpression. Furthermore, overexpression of CAV1 abrogated the CD26-regulated MMP1 induction in CRC cell lines. This study demonstrated the functional roles of CD26 in inducing CRC migration, invasion, angiogenesis and metastasis and identified the potential involvement of MMP1 and CAV1 in such process. CD26 is an attractive therapeutic target for combating tumor progression to improve the prognosis of CRC patients. 相似文献
35.
P. D. D. Dominic S. Kaliyamoorthy R. Murugan 《The International Journal of Advanced Manufacturing Technology》2004,24(1-2):76-80
Job shop scheduling (JSS) problems consist of a set of machines and a collection of jobs to be scheduled. Each job consists of several operations with a specified processing order. In this paper, a job shop model problem is scheduled with the help of the Giffler and Thompson algorithm using a priority dispatching rule (PDR). A conflict based PDR is used to schedule the job shop model by using Genetic Algorithms (GAs). An iterative method is applied to the job model to find the optimal conflict-based PDR order and the operation sequence. The same job shop model is also scheduled based on an operation using simulated annealing (SA) and hybrid simulated annealing (HSA). A makespan of the job model is used as an objective. These four methods are considered as different solutions for each problem. A two-way analysis of variance (ANOVA) is applied to test its significance. 相似文献
36.
This article suggests a novel method to retrieve a narrowband signal sent in a multipath environment with a delay spread considering ISI between symbols. The proposed method does not require any preamble nor known signal. Using the joint direction and time delay of arrivals estimation algorithm developed in prior work, the directions and time delays of arrival in the multipath channel are jointly estimated and associated while keeping a low computational cost. In this process, a MVDR beamformed copy of each arriving signal is created. The quality of these “pseudo copies” is evaluated and compared to the original direct and reflected signals in this work. Another beamforming method, the Moore–Penrose pseudoinverse, with better retrieval of the direct and reflected signals is also proposed. Using a simple delay-and-sum operation on the previously beamformed copies, it is possible to substantially improve the the system’s performance in terms of bit error rate. An approach using oversampling on the array antenna is introduced to improve performance. Numerical simulations are discussed to support theory. 相似文献
37.
Annabel Krebs Thorsten Knoll Dominic Nu?baum Thomas Velten 《Microsystem Technologies》2012,18(11):1871-1877
Investigations and analyses of body fluids like serum or whole blood are essential tasks in biomedical research in order to understand and diagnose diseases, to conduct pharmacological tests or to culture cells. Therefore, microfluidic systems provide a favorable tool for processing fluid samples as they allow downscaling of sample volumes and handling of single fluid components such as cells or proteins. For this reason, we present simple fabrication techniques for microchannel systems using polymer materials only. The demonstrated fabrication procedures are based on combinations of acrylic glass and the photo resists SU-8 and PerMX3020. On the one hand, these materials are low-priced compared to conventional silicon or glass. On the other hand, they have not shown any interaction with blood or other cell suspensions within the frame of our study. Furthermore, their transparency guarantees an easy observability of all processes within the system. Depending on the channel dimensions, different adhesion bonding techniques for closing of the systems are applied, whereas the fluidic interfaces are included by mechanical drilling. Summing up, we provide complete fabrication processes for fluidic systems which are simpler and more cost-effective than conventional methods and yet cope with all essential requirements for microfluidic applications. 相似文献
38.
Michael H. Butterworth Mikhail A. Semenov Andrew Barnes Dominic Moran Jonathan S. West Bruce D. L. Fitt 《Journal of the Royal Society Interface》2010,7(42):123-130
Effects of climate change on productivity of agricultural crops in relation to diseases that attack them are difficult to predict because they are complex and nonlinear. To investigate these crop–disease–climate interactions, UKCIP02 scenarios predicting UK temperature and rainfall under high- and low-CO2 emission scenarios for the 2020s and 2050s were combined with a crop-simulation model predicting yield of fungicide-treated winter oilseed rape and with a weather-based regression model predicting severity of phoma stem canker epidemics. The combination of climate scenarios and crop model predicted that climate change will increase yield of fungicide-treated oilseed rape crops in Scotland by up to 0.5 t ha−1 (15%). In contrast, in southern England the combination of climate scenarios, crop, disease and yield loss models predicted that climate change will increase yield losses from phoma stem canker epidemics to up to 50 per cent (1.5 t ha−1) and greatly decrease yield of untreated winter oilseed rape. The size of losses is predicted to be greater for winter oilseed rape cultivars that are susceptible than for those that are resistant to the phoma stem canker pathogen Leptosphaeria maculans. Such predictions illustrate the unexpected, contrasting impacts of aspects of climate change on crop–disease interactions in agricultural systems in different regions. 相似文献
39.
Maurizio Bozzi Dominic Deslandes Paolo Arcioni Luca Perregrini Ke Wu Giuseppe Conciauro 《国际射频与微波计算机辅助工程杂志》2005,15(3):296-306
This article presents a substrate integrated waveguide, named the substrate‐integrated slab waveguide (SISW), which exhibits a wide operation bandwidth. It consists of an integrated rectangular waveguide filled with a periodically perforated dielectric medium. An efficient procedure has been developed for the calculation of the dispersion diagram of SISWs, based on the Floquet theorem, in conjunction with the segmentation technique and the boundary‐integral–resonant‐mode‐expansion (BI‐RME) method. Numerical and experimental results confirm the performance of these waveguides and the efficiency of the analysis method. © 2005 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2005. 相似文献
40.
Noting that the group may be viewed as a 6-parameter gauge group that leaves the Lagrangian of elasticity theory invariant, the Yang-Mills universal gauge theory construction is used to erect a complete continuum theory of material bodies with dislocation and disclination fields. Breaking of the homogeneity of the action of is shown to give rise to disclinations and rotational dislocations while homogeneity breaking of gives rise to translational dislocations. A rigorous justification for replacing displacement gradients by the components of the distortion tensor and Newtonian kinematic velocity by distortional velocity is obtained. Exact determinations are made of the elastic excess forces, the forces on dislocations and the forces on disclinations, and these forces are shown to be totally equilibrating in all instances. Implications of the theory are given and an analysis is made of the field equations and associated dispersion relations that obtain in a disclination free material in the linear elasticity approximation. 相似文献