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101.
Chiara Bellocchi Angelica Carandina Beatrice Montinaro Elena Targetti Ludovico Furlan Gabriel Dias Rodrigues Eleonora Tobaldini Nicola Montano 《International journal of molecular sciences》2022,23(5)
The autonomic nervous system (ANS) and the immune system are deeply interrelated. The ANS regulates both innate and adaptive immunity through the sympathetic and parasympathetic branches, and an imbalance in this system can determine an altered inflammatory response as typically observed in chronic conditions such as systemic autoimmune diseases. Rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis all show a dysfunction of the ANS that is mutually related to the increase in inflammation and cardiovascular risk. Moreover, an interaction between ANS and the gut microbiota has direct effects on inflammation homeostasis. Recently vagal stimulation techniques have emerged as an unprecedented possibility to reduce ANS dysfunction, especially in chronic diseases characterized by pain and a decreased quality of life as well as in chronic inflammation. 相似文献
102.
Dmitrii Iudin Marina Vasilieva Elena Knyazeva Viktor Korzhikov-Vlakh Elena Demyanova Antonina Lavrentieva Yury Skorik Evgenia Korzhikova-Vlakh 《International journal of molecular sciences》2022,23(5)
The growing number of drug-resistant pathogenic bacteria poses a global threat to human health. For this reason, the search for ways to enhance the antibacterial activity of existing antibiotics is now an urgent medical task. The aim of this study was to develop novel delivery systems for polymyxins to improve their antimicrobial properties against various infections. For this, hybrid core–shell nanoparticles, consisting of silver core and a poly(glutamic acid) shell capable of polymyxin binding, were developed and carefully investigated. Characterization of the hybrid nanoparticles revealed a hydrodynamic diameter of approximately 100 nm and a negative electrokinetic potential. The nanoparticles demonstrated a lack of cytotoxicity, a low uptake by macrophages, and their own antimicrobial activity. Drug loading and loading efficacy were determined for both polymyxin B and E, and the maximal loaded value with an appropriate size of the delivery systems was 450 µg/mg of nanoparticles. Composite materials based on agarose hydrogel were prepared, containing both the loaded hybrid systems and free antibiotics. The features of polymyxin release from the hybrid nanoparticles and the composite materials were studied, and the mechanisms of release were analyzed using different theoretical models. The antibacterial activity against Pseudomonas aeruginosa was evaluated for both the polymyxin hybrid and the composite delivery systems. All tested samples inhibited bacterial growth. The minimal inhibitory concentrations of the polymyxin B hybrid delivery system demonstrated a synergistic effect when compared with either the antibiotic or the silver nanoparticles alone. 相似文献
103.
User Modeling and User-Adapted Interaction - This paper presents an authoring environment, which supports cultural heritage professionals in the process of creating and deploying a wide range of... 相似文献
104.
Elena Pellizzoni Daniel Trabucchi Tommaso Buganza 《Creativity & Innovation Management》2019,28(4):464-476
Open Innovation is a leading paradigm in the current landscape, and scholars have been highly focused on defining the characteristics and capabilities that firms need to implement it successfully. This research aims to understand how organizations may implement inbound OI projects. Relying on a multiple case study approach and based on primary and secondary sources, this research highlights two main approaches: team‐centred and individual‐centred. The two approaches are discussed according to previous studies, highlighting how the first one is particularly coherent with previous research on Open Innovation, while the second one offers great insights from an Agile Project Management perspective. In particular, this research suggests how the Open Innovation literature can be enriched by considering the recent advancements in the Agile literature, valuing the individual and its autonomy to embrace external ideas from an OI perspective. 相似文献
105.
Parra Oihane Rodriguez Igor Jauregi Ekaitz Lazkano Elena Ruiz Txelo 《Intelligent Service Robotics》2019,12(4):319-332
Intelligent Service Robotics - GidaBot is an application designed to set up and run a heterogeneous team of robots to act as tour guides in multi-floor buildings. Although the tours can go through... 相似文献
106.
Su Hang Sandoval Juan Vieyres Pierre Poisson Gérard Ferrigno Giancarlo De Momi Elena 《International Journal of Control, Automation and Systems》2018,16(6):2915-2923
International Journal of Control, Automation and Systems - In this paper, a safety-enhanced collaborative control framework is proposed for tele-operated minimally invasive surgery (MIS) using a... 相似文献
107.
Elena Chamizo Santiago Miguel Enamorado Martin Suter 《Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms》2008,266(22):4948-4954
Plutonium isotopes have been recently added to the list of radionuclides that can be measured with the new generation of compact AMS facilities. In this paper we present first experimental results concerning the development of the plutonium AMS technique at 680 kV on the 1 MV AMS system at the Centro Nacional de Aceleradores (CNA) in Sevilla, Spain. This is the first compact AMS machine designed and manufactured by High Voltage Engineering Europa. As we demonstrate, the obtained backgrounds for 239,240Pu, of about 106 atoms, and the 239Pu/238U mass suppression factor, in the range of 10−9, compare to the ones achieved on other AMS facilities. With the measurement of reference materials provided by the International Atomic Energy Agency (IAEA-375, IAEA-Soil-6, IAEA-381) and samples already studied on the 600 kV compact ETH/PSI AMS system at Zürich, we show that the CNA system can be perfectly used for the routine measurement of plutonium isotopes at environmental levels. 相似文献
108.
109.
Dr. Elena S. Reckzeh Prof. Dr. Dr. Herbert Waldmann 《Chembiochem : a European journal of chemical biology》2020,21(1-2):45-52
Glucose addiction is observed in cancer and other diseases that are associated with hyperproliferation. The development of compounds that restrict glucose supply and decrease glycolysis has great potential for the development of new therapeutic approaches. Addressing facilitative glucose transporters (GLUTs), which are often upregulated in glucose-dependent cells, is therefore of particular interest. This article reviews a selection of potent, isoform-selective GLUT inhibitors and their biological characterization. Potential therapeutic applications of GLUT inhibitors in oncology and other diseases that are linked to glucose addiction are discussed. 相似文献
110.
Olga Leuner Jaroslav Havlik Jana Hummelova Elena Prokudina Pavel Novy Ladislav Kokoska 《Journal of the science of food and agriculture》2013,93(3):575-579
BACKGROUND: Isoflavones and coumestrol from dietary legumes are plant constituents showing multiple beneficial effects on humans. Owing to their ability to bind with mammalian estrogenic receptors and thereby intervention in several kinds of hormone‐related cancers, they have received much attention. Soybean (Glycine max) is currently the major source of isoflavonoids in human diet. However, dozens of tropical and subtropical leguminous species remain unexplored for their isoflavonoids content. RESULTS: We have analyzed 55 extracts from 41 tropical and subtropical legume species used either in human or animal diet by high‐performance liquid chromatography for the content of soy isoflavones, biochanin A, daidzein, daidzin, formononetin, genistein, genistin, sissotrin, ononin and the coumestan coumestrol. Genistein and biochanin A were the most abundant compounds. The highest content of genistein was found in aerial parts of Andira macrothyrsa, seeds of Pachyrhizus tuberosus and aerial parts of Calopogonium mucunoides (598, 250 and 184 µg g?1, respectively) and biochanin A in aerial parts of Cratylia argentea, C. mucunoides and flowers of A. macrothyrsa (76, 53 and 40 µg g?1, respectively). CONCLUSION: None of the samples tested was richer overall source of soy isoflavones and coumestrol than soybean; nevertheless several species (C. mucunoides or A. macrothyrsa) may serve as a promising source of individual compounds. © 2012 Society of Chemical Industry 相似文献