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In this study, sea bream, sea bass, anchovy and trout were captured and recorded using a digital camera during refrigerated storage for 7 days. In addition, their total viable counts (TVC) were determined on a daily basis. Based on the TVC, each fish was classified as ‘fresh’ when it was <5 log cfu per g, and as ‘not fresh’ when it was >7 log cfu per g. They were uploaded on a web-based machine learning software called Teachable Machine (TM), which was trained about the pupils and heads of the fish. In addition, images of each species from different angles were uploaded to the software in order to ensure the recognition of fish species by TM. The data of the study indicated that the TM was able to distinguish fish species with high accuracy rates and achieved over 86% success in estimating the freshness of the fish species tested. 相似文献
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Dr. Jelena Melesina Conrad V. Simoben Lucas Praetorius Emre F. Bülbül Dr. Dina Robaa Prof. Dr. Wolfgang Sippl 《ChemMedChem》2021,16(9):1336-1359
This review classifies drug-design strategies successfully implemented in the development of histone deacetylase (HDAC) inhibitors, which have many applications including cancer treatment. Our focus is on especially demanded selective HDAC inhibitors and their structure-activity relationships in relation to corresponding protein structures. The main part of the paper is divided into six subsections each narrating how optimization of one of six structural features can influence inhibitor selectivity. It starts with the impact of the zinc binding group on selectivity, continues with the optimization of the linker placed in the substrate binding tunnel as well as the adjustment of the cap group interacting with the surface of the protein, and ends with the addition of groups targeting class-specific sub-pockets: the side-pocket-, lower-pocket- and foot-pocket-targeting groups. The review is rounded off with a conclusion and an outlook on the future of HDAC inhibitor design. 相似文献
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Ömer Kesmez Esin Akarsu H. Erdem Çamurlu Emre Yavuz Murat Akarsu Ertuğrul Arpaç 《Ceramics International》2018,44(3):3183-3188
Single layer and multilayer films consisting of SnO2, Ta2O5, SiO2, TiO2, indium tin oxide (ITO) and antimony tin oxide (ATO) have been prepared by sol-gel dip coating technique. All of the multilayer films contained a SiO2 top layer, which was composed of SiO2 nanoparticles. The other films had polymeric character. Obtained films were characterized by ellipsometry, XRD, AFM and SEM. Light transmittance values of the films were compared. Films other than SiO2 and Ta2O5 were found to have crystalline structure. Thickness values of the films were in the range of 30–115 nm and roughness values were in 1.2–23 nm range. Single layer porous silica provided 95% light transmittance, whereas ITO-TiO2-SiO2 multilayer film provided a light transmittance of 97.2%. 相似文献
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Guzel Muhammed Huseyin Unal Recep Emre Onder Ahmet Sen Muhammed Arif Kose Faruk 《Journal of Mechanical Science and Technology》2021,35(3):1301-1308
Journal of Mechanical Science and Technology - The energy demand of world is increasing worldwide because of increasing population and developing technology. The use of environmentally friendly... 相似文献
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David J. Banner Emre Firlar Pavel Rehak Abhijit H. Phakatkar Tara Foroozan Jodi K. Osborn Lioudmila V. Sorokina Surya Narayanan Talia Tahseen Yusuf Baggia Petr Král Tolou Shokuhfar Reza Shahbazian-Yassar 《Advanced functional materials》2021,31(18):2007736
Calcium oxalate (CaOx) is the major phase in kidney stones and the primary calcium storage medium in plants. CaOx can form crystals with different lattice types, water contents, and crystal structures. However, the conditions and mechanisms leading to nucleation of particular CaOx crystals are unclear. Here, liquid-cell transmission electron microscopy and atomistic molecular dynamics simulations are used to study in situ CaOx nucleation at different conditions. The observations reveal that rhombohedral CaOx monohydrate (COM) can nucleate via a classical pathway, while square COM can nucleate via a non-classical multiphase pathway. Citrate, a kidney stone inhibitor, increases the solubility of calcium by forming calcium-citrate complexes and blocks oxalate ions from approaching calcium. The presence of multiple hydrated ionic species draws additional water molecules into nucleating CaOx dihydrate crystals. These findings reveal that by controlling the nucleation pathways one can determine the macroscale crystal structure, hydration state, and morphology of CaOx. 相似文献