Transdermal Absorption of Zidovudine from Ethanol-Isopropyl Myristate Mixed System and Influence of Probenecid on It in Rats

Transdermal absorption of zidovudine (AZT) from an ethanol-isopropyl myristate (IPM) mixed system was examined in rats. For comparison of bioavailability (BA) after topical applications, 0.25 ml of the ethanol/IPM system containing 40% ethanol and 60 mM AZT was applied as a standard formulation. Values of the area under the plasma concentration-time curves of AZT for 8 hr (AUC_0-8), as indices of BA, following application of various formulations were compared with that of the standard formulation. Then the influence of content of the drug and ethanol, and application volume of the system was evaluated. BA was effectively improved only when the total amount of ethanol applied on the skin was increased. On the other hand, simultaneous transdermal application of AZT and probenecid increased the AU_0-8, of AZT without necessitating the increase in ethanol content in the formulation. In addition, coadministered probenecid improved cerebrospinal fluid/plasma concentration ratio of AZT.     

大力发展循环经济实现企业可持续发展

莱钢始建于1970年1月,现控股莱钢股份、鲁银投资两个上市公司及齐鲁证券等25个子公司。莱钢是中国冶金行业首批通过ISO9002质量管理体系、ISO14001环境管理体系和OHSAS18001职业安全健康管理体系国家认证的企业。2005年,莱钢被国家发改委确定为国家第一批循环经济试点单位。     

中小城镇住宅消防设施现状及建设管理探索

通过对西部某小城市的住宅消防设施建设和管理现状的调查 ,反映了占西部绝大部分城市面积的中小城镇的住宅消防设施十分令人担忧的现状 ,分析了造成这一现状的原因 ,提出了解决这一问题的建设管理思路     

观赏草在庭园中的设计与应用

观赏草以其灵动的景观特质，草类特有的自然色调，飘逸的质感越来越受到设计师们的青睐，用于焦点、绿蒿、花镜、镶边均有不凡的表现，虽为草类，却有着灌木的功能。     

董公馆：嫁接之美

董公馆是一个6层楼的公寓，依山而建，业主将他交到设计师手里，让他在这基础上活活变出一个精美的“公馆”。     

＇06香港专利授权展规模创历年之最

第五届香港专利授权展7月4日至6日在香港会展中心2B展馆举行。本届专利授权展参展商逾百家，将展示更多的授权项目，举办内容丰富的研讨会，参观者不仅可以从展会中寻找商机。而且可以获得新的信息，从中窥测到专利授权的市场走向。[编者按]     

专家系统在化工中的应用进展

本文综述了近年来专家系统在化工领域的应用状况，并指出今后的发展趋势。     

世界杯小组赛出线预测程序

每届足球世界杯都会受到无数人的关注,媒体和个人都很热衷比赛结果的预测。该程序根据世界杯比赛胜负出线规则对比赛结果进行预测。     

基于VC＋＋的仿真训练系统编程

给出了以PCI-I64IOT型I/O卡为核心的硬件接口电路和软件设计思想,详细分析了编程方法。实践表明,利用该系统能完全实现侦察专业的全部训练科目,满足部队和院校训练的需要。     

Hot corrosion ofα-SiC ceramics by V2O5 melt

The corrosion behaviour of-SiC in V₂O₅ melt has been investigated at elevated temperatures. The corrosion products on the surface of the specimen are removed using HF. The morphologies are also examined. From the observations of bubble formation in the scale and the temperature dependence of the corrosion rate, a kinetic mechanism is proposed. Based on the consistency of the plotted data with the proposed equation and high values of surface reaction rate constant, a diffusion controlling process has been developed.