Wind action evaluation on tension roofs of hyperbolic paraboloid shape

The need to cover large areas while maintaining unobstructed interior spaces is a permanent challenge in the design of medium and large span roofs. In compliance with international trends, this paper proposes anew a technology already used in the past for this type of application: tensile structures made of nets of tension cables. Although such structures meet the requirements of today’s market in terms of lightness, innovation of materials, cost-effectiveness and lack of intermediate supports, tension structures are rarely used in Italy, due to the lack of clear regulations on the structural design and the determination of environmental stresses on complex shapes such as hyperbolic paraboloids. This research follows two consecutive steps: the first one aims at developing an optimized procedure of preliminary designs for the cable structure; the second one focuses on the study of wind action on these structures. The hyperbolic paraboloid is the chosen shape for a parameterization leading to an optimized design of this kind of structure.     

Coupling atomistic and continuous media models for electronic device simulation

In this article we highlight the necessity of atomistic based, fully quantum mechanical simulation approaches for modern electronic devices and their coupling with classical models. We review different ways of such couplings and provide application examples.     

Effects of two different sourdoughs on the characteristics of Pandoro, a typical Italian sweet leavened baked good

Pandoro is a traditional Italian sweet-leavened baked product, usually consumed at Christmas. It is manufactured according to specific procedures and preparation starts from a sourdough called ‘‘madre’’ (mother sponge) continuously refreshed. This sourdough is the result of a complex microbial association including yeasts and lactic acid bacteria (LAB) and its use can improve sensory quality and shelf-life of the resulting products. The aim of this work was to evaluate the effect of the use of two different sourdoughs matured at different temperature (13 and 19 °C) on some metabolites, which can affect the organoleptic characteristics of Pandoro. Different samples, taken throughout the 19 h of process, were analysed for the determination of yeast and LAB counts, pH, a_w, carbohydrates, organic acids content and volatile profile. The results showed that, at the end of fermentation process, the sourdough propagated at 19 °C reached lower pH values than that at 13 °C. This was probably due to higher LAB counts (1 log unit higher), resulting also in higher lactic acid concentration and faster sugars depletion. On the contrary, temperature of dough during maturation did not affected yeast concentrations. Different production processes strongly affected also the volatile profile, both of sourdough at the end of fermentation and of the final products.     

Production of Caseinophosphopeptides from Na-Caseinates Prepared from the Milk of Several Species by a Proteinase of Lactobacillus helveticus PR4

The aim of this work was to produce caseinophosphopeptides (CPPs) from Na-caseinates prepared from the milk of six species (bovine, sheep, goat, pig, buffalo, human) hydrolyzed by a partially purified proteinase from Lactobacillus helveticus PR4 and to characterize the CPP preparations by RP-FPLC (reversed-phase fast-protein liquid chromatography) and for calcium solubilizing/binding activity. The yield of CPPs ranged from 0.60 to 1.86% of the original proteins. The calcium-solubilizing activity varied from 2.5 (human CPPs) to 11.4 (buffalo CPPs) mg Ca²⁺ mg^-1 CPP. Moreover, minor differences in calcium-binding ability between the CPP from different species were observed. This work showed that CPPs with different calcium-solubilizing activity can be produced from various Na-caseinates by a Lb. helveticus proteinase. Milks having casein-fractions with similar amino acid sequences (e.g., sheep and goat), showed CPPs with the same activity. The data generated in this study show the potential of different caseins to yield CPPs and may help in the selection of milk for the production of functional foods enriched in CPPs.     

A Comparative Analysis of the In Vitro Anticancer Activity of Iridium(III) {η5-C5Me4R} Complexes with Variable R Groups

Piano-stool iridium complexes based on the pentamethylcyclopentadienyl ligand (Cp*) have been intensively investigated as anticancer drug candidates and hold much promise in this setting. A systematic study aimed at outlining the effect of Cp* mono-derivatization on the antiproliferative activity is presented here. Thus, the dinuclear complexes [Ir(η⁵-C₅Me₄R)Cl(μ-Cl)]₂ (R = Me, 1a; R = H, 1b; R = Pr, 1c; R = 4-C₆H₄F, 1d; R = 4-C₆H₄OH, 1e), their 2-phenylpyridyl mononuclear derivatives [Ir(η⁵-C₅Me₄R)(k_N,k_CPhPy)Cl] (2a–d), and the dimethylsulfoxide complex [Ir{η⁵-C₅Me₄(4-C₆H₄OH)}Cl₂(κ_S-Me₂S=O)] (3) were synthesized, structurally characterized, and assessed for their cytotoxicity towards a panel of six human and rodent cancer cell lines (mouse melanoma, B16; rat glioma, C6; breast adenocarcinoma, MCF-7; colorectal carcinoma, SW620 and HCT116; ovarian carcinoma, A2780) and one primary, human fetal lung fibroblast cell line (MRC5). Complexes 2b (R = H) and 2d (4-C₆H₄F) emerged as the most active ones and were selected for further investigation. They did not affect the viability of primary mouse peritoneal cells, and their tumoricidal action arises from the combined influence on cellular proliferation, apoptosis and senescence. The latter is triggered by mitochondrial failure and production of reactive oxygen and nitrogen species.     

Energy‐efficient single‐clock‐cycle binary comparator

A new fast low‐power single‐clock‐cycle binary comparator is presented. High speed is assured by using parallel‐prefix architecture, whereas low power is guaranteed by reducing the switching activities of the internal nodes. When implemented with the ST 90 nm 1 V CMOS technology, the proposed circuit exhibits a 4.5 GHz maximum running frequency and 0.77µW/ MHz energy dissipation. Copyright © 2010 John Wiley & Sons, Ltd.     

Pre-fermentative replacement of sulphur dioxide by lysozyme and oenological tannins: Effect on the formation and evolution of volatile compounds during the bottle storage of white wines

In this work, the effects on the volatile profile of the pre-fermentative substitution of SO₂ with lysozyme and oenological tannins were studied in white wines. At the same time, in order to understand the changes of volatile compounds in SO₂-free wines, the evolution of volatiles was evaluated over 1 year of storage in bottles. For this purpose, a number of laboratory scale fermentations of SauvignonBlanc musts were carried out and the effects of three variables (SO₂, lysozyme and oenological tannins) were investigated by means of GC–MS analysis. Results showed that the replacement of SO₂ with lysozyme and oenological tannins influenced the volatile composition of wines at the end of the alcoholic fermentation. Wines fermented with SO₂ showed higher total alcohol amounts, while the presence of oenological tannins augmented the level of esters. The presence of SO₂ influenced also the alcohols and esters profiles of wines during bottle storage. Moreover, the presence of oenological tannins displayed a positive role in maintaining the amounts of esters over certain levels in wine stored for 1 year, likely due to their oxygen scavenging ability. By contrast, acids were less affected by the investigated adjuvants both at the end of the alcoholic fermentation and during the storage time.     

Consideration of uncertainties in LCA for infrastructure using probabilistic methods

The construction and usage of transport infrastructure are major causes of greenhouse gas emissions and energy consumption. The effects of resource consumption and pollutant emissions are often quantified through Life Cycle Assessment (LCA) models. All decisions made in infrastructure projects during the whole life cycle are afflicted by uncertainty, e.g. physical properties of materials or amount of pollutants emitted by certain processes. The pervasive role of uncertainty is reflected in LCA models, which therefore should consider uncertainty from various sources and provide a sound quantification of their effects. The aim of the work presented in this paper is to give an overview of different sources of uncertainty in LCA of infrastructure projects and to describe systematic methods to evaluate their influence on the results. The possibility of including uncertainty in a LCA-tool for infrastructure is presented, studying the sensitivity of the model output to the input parameters and two alternative approaches for propagation of uncertainty using two case studies. It is shown that, besides the influence of uncertainty in emission factors, other inputs such as material amounts and service life could contribute significantly to the variability of model output and has to be considered if reliable results are sought.