Effects of coating layer and release medium on release profile from coated capsules with Eudragit FS 30D: an in vitro and in vivo study

The aim of the present research was to evaluate the impact of coating layers on release profile from enteric coated dosage forms. Capsules were coated with Eudragit FS 30D using dipping method. The drug profile was evaluated in both phosphate buffer and Hank’s solutions. Utilization X-ray imaging, gastrointestinal transmission of enteric coated capsules was traced in rats. According to the results, no release of the drug was found at pH 1.2, and the extent of release drug in pH 6.8 medium was decreased by adding the coating layers. The results indicated single-layer coated capsules in phosphate buffer were significantly higher than that in Hank’s solution. However, no significant difference was observed from capsules with three coating layers in two different dissolution media. X-ray imaging showed that enteric coated capsules were intact in the stomach and in the small intestine, while disintegrated in the colon.     

Impacts of Paris agreement,fossil fuel consumption,and net energy imports on CO2 emissions: a panel data approach for three West European countries

Clean Technologies and Environmental Policy - The Paris agreement is a legally binding international treaty on climate change. This study examines the Paris agreement and other explanatory...     

Generalized Storage Equations for Flood Routing with Nonlinear Muskingum Models

Water Resources Management - The nonlinear Muskingum model is a leading method for hydrologic routing. The efficiency of the nonlinear Muskingum model for routing of hydrograph outflow has been...     

A mixed resilient‐efficient approach toward blood supply chain network design

Unlike its inherent beneficial attributes, the blood supply chain is very complex due to its uncertain nature and irregular donation besides a high vulnerability to disruptions. In this regard, this study provides a multi‐objective integrated resilient‐efficient model to design a blood supply chain network under uncertainty. To evaluate the efficiency, an augmented form of the data envelopment analysis model is incorporated into the extended model. On the other hand, to improve supply chain resilience, different resiliency measures as optimization tools are introduced and inserted into the considered network. As blood donors have a main role in the blood supply chain, this paper undertakes motivational social aspects to stimulate blood donation for reducing possible shortages. Furthermore, to handle the multi‐objective problem, an interactive fuzzy approach is utilized. Finally, to indicate the applicability of the extended model and its solution approaches, a case study is provided considering realistic data. The results revealed that simultaneously considering all three measures of efficiency, resilience, and cost can assist in improvement of blood supply chain network design and a trade‐off among these three measures can be set by decision maker's preferences.     

SIW Corporate-Feed Network for Circular Polarization Slot Array Antenna

Wireless Personal Communications - In this paper, multilayer feeding network for linear slot array antenna is studied. A substrate integrated waveguide (SIW) corporate-feed network for linear slot...     

Optimal power flow of HVDC system using teaching–learning-based optimization algorithm

In this paper, a solution to the optimal power flow (OPF) problem in electrical power networks is presented considering high voltage direct current (HVDC) link. Furthermore, the effect of HVDC link converters on the active and reactive power is evaluated. An objective function is developed for minimizing power loss and improving voltage profile. Gradient-based optimization techniques are not viable due to high number of OPF equations, their complexity and equality and inequality constraints. Hence, an efficient global optimization method is used based on teaching–learning-based optimization (TLBO) algorithm. The performance of the suggested method is evaluated on a 5-bus PJM network and compared with other algorithms such as particle swarm optimization, shuffled frog-leaping algorithm and nonlinear programming. The results are promising and show the effectiveness and robustness of TLBO method.

     

A CPW-fed wearable antenna at ISM band for biomedical and WBAN applications

Wireless Networks - In this paper, a Mercedes-Benz logo antenna with a metal plate located at an optimized distance from the proposed antenna is introduced as a wearable antenna to operate in the...     

Improving Daily and Monthly River Discharge Forecasts using Geostatistical Ensemble Modeling

Water Resources Management - In this paper, daily and monthly runoff discharge forecasts are improved by developing an ensemble model based on the Bayesian maximum entropy (BME), which integrates...     

In Situ Synthesis of Ultrahigh Molecular Weight Polyethylene/Graphene Oxide Nanocomposite Using the Immobilized Single-site Catalyst

We address the immobilization of single-site catalyst on the graphite oxide (GO) surface using methylaluminoxane. Ethylene polymerization was performed using the immobilized catalyst and the nanocomposite of ultrahigh molecular weight polyethylene (UHMWPE)/GO with less entanglement density was obtained. It was observed that the drawability, mechanical and thermal properties of the produced polymer significantly are affected by the anchoring of polymer chains to the GO nanosheets. The orientation and location of crystalline lamellae and nanosheets were verified by microscopic techniques. Besides, X-ray analysis demonstrated the dispersion of GO within the UHMWPE phase and crystallinity of UHMWPE/GO nanocomposites enhanced during drawing process.