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51.
Vivanco F Mas S Darde VM De la Cuesta F Alvarez-Llamas G Barderas MG 《Proteomics. Clinical applications》2007,1(9):1102-1122
The characterization of patients with acute coronary syndromes (ACS) at the molecular and cellular levels provides a novel vision for understanding the pathological and clinical expression of the disease. Recent advances in proteomic technologies permit the evaluation of systematic changes in protein expression in many biological systems and have been extensively applied to cardiovascular diseases (CVD). The cardiovascular system is in permanent intimate contact with blood, making blood-based biomarker discovery a particularly worthwhile approach. Thus, proteomics can potentially yield novel biomarkers reflecting CVD, establish earlier detection strategies, and monitor response to therapy. Here we review the different proteomic strategies used in the study of atherosclerosis and the novel proteins differentially expressed and secreted by atherosclerotic lesions which constitute novel potential biomarkers (HSP-27, Cathepsin D). Special attention is paid to MS-Imaging of atheroma plaque and the generation, for the first time, of 2-D images of lipids, showing the distribution of these molecules in the different areas of the atherosclerotic lesions. In addition new potential biomarkers have been identified in plasma (amyloid A1α, transtherytin), circulating cells (protein profile in monocytes from ACS patients) and individual cells constituents of atheroma plaques (endothelial, VSMC, macrophages) which provide novel insights into vascular pathophysiology. 相似文献
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In this paper, we develop a numerical method for the N-dimensional sine-Gordon equation using differentiation matrices, in the theoretical frame of matrix differential equations.Our method avoids calculating exponential matrices, is very intuitive and easy to express, and can be implemented without toil in any number of spatial dimensions. Although there is currently a vast literature on the numerical treatment of the one-dimensional sine-Gordon equation, the references for the two-dimensional case are much sparser, and virtually nonexistent for higher dimensions.We apply it to a battery of two-dimensional problems taken from the literature, showing that it largely outperforms the previously existing algorithms; while for three-dimensional problems, the results seem very promising. 相似文献
54.
TangiWheel: A Widget for Manipulating Collections on Tabletop Displays Supporting Hybrid Input Modality 下载免费PDF全文
In this paper we present TangiWheel,a collection manipulation widget for tabletop displays.Our implementation is flexible,allowing either multi-touch or interaction,or even a hybrid scheme to better suit user choice and convenience.Different TangiWheel aspects and features are compared with other existing widgets for collection manipulation.The study reveals that TangiWheel is the first proposal to support a hybrid input modality with large resemblance levels between touch and tangible interaction styles.Several experiments were conducted to evaluate the techniques used in each input scheme for a better understanding of tangible surface interfaces in complex tasks performed by a single user (e.g.,involving a typical master-slave exploration pattern).The results show that tangibles perform significantly better than fingers,despite dealing with a greater number of interactions,in situations that require a large number of acquisitions and basic manipulation tasks such as establishing location and orientation.However,when users have to perform multiple exploration and selection operations that do not require previous basic manipulation tasks,for instance when collections are fixed in the interface layout,touch input is significantly better in terms of required time and number of actions.Finally,when a more elastic collection layout or more complex additional insertion or displacement operations are needed,the hybrid and tangible approaches clearly outperform finger-based interactions. 相似文献
55.
Fernando Turrado García Luis Javier García Villalba Javier Portela 《Expert systems with applications》2012,39(12):10590-10599
To be able of anticipate demand is a key factor for commercial success in the supply-chain sector. The benefits can be grouped around two main concepts: firstly the optimization of operations through the development of optimal strategies for procurement and secondly the stock reduction that reduces storage costs, handling, etc. There is currently a variety of methods for making predictions, these methods vary from pure statistical methods such as exponential smoothing Holt-Winters or ARIMA models, to those based on artificial intelligence techniques like neural networks or fuzzy systems. However, despite being able to build accurate models, in managing the supply chain based on forecasts there is a problem known as “Forrester effect” irrespective of the model chosen. To monitor the impact of this effect, given the volume of information handled in large corporations, is a very expensive task (often manual) for such corporations because it requires investigating issues such as the adequacy of the model, allocation of known models to the sales time series, discovery of new patterns of behavior, etc. This article proposes an intelligent system based on support vector machines to solve problems concerning the allocation and discovery of new models. With this focus in mind, the system objective is to build groups of time series that share the same forecasting model. For the identification of new models, the system will assign “virtual models” for those groups that do not have a predefined pattern. Using the proposed method, it has been possible to group a sample of more than 14,000 time series (real data taken from a store) in around 70 categories, of which only 12 of them already grouped over 98% of the total. 相似文献
56.
Ricardo Soto Hakan Kjellerstrand Orlando Durán Broderick Crawford Eric Monfroy Fernando Paredes 《Expert systems with applications》2012,39(13):11423-11427
Cell formation consists in organizing a plant as a set of cells, each of them containing machines that process similar types or families of parts. The idea is to minimize the part flow among cells in order to reduce costs and increase productivity. The literature presents different approaches devoted to solve this problem, which are mainly based on mathematical programming and on evolutionary computing. Mathematical programming can guarantee a global optimal solution, however at a higher computational cost than an evolutionary algorithm, which can assure a good enough optimum in a fixed amount of time. In this paper, we model and solve this problem by using state-of-the-art constraint programming (CP) techniques and Boolean satisfiability (SAT) technology. We present different experimental results that demonstrate the efficiency of the proposed optimization models. Indeed, CP and SAT implementations are able to reach the global optima in all tested instances and in competitive runtime. 相似文献
57.
Laura Bix Sujit S. Sansgiry Robert Clarke Fernando Cardoso Gauri S. Shringarpure 《Packaging Technology and Science》2004,17(1):3-11
This study investigates the coverage of federally mandated information on over‐the‐counter (OTC) drug labels by electronic article surveillance (EAS) tags applied to the exterior of cartons. Using adult‐strength analgesics containing acetaminophen as a case study, researchers investigated the issue in Houston, Texas (24 stores) and Lansing, Michigan (33 stores). The information obscured by EAS tags was identified and classified for a total of 849 packages using a standardized data collection instrument. The results indicated that 293 packages examined, or 34.5%, had information mandated by the US Food and Drug Administration (US FDA) fully or partially obscured by the EAS tags. Retailers and manufacturers should be aware of such practices to reduce potential liability. Recommendations for improving EAS tag usage on OTC products are presented. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
58.
Primal Fernando Bjrn Palm Per Lundqvist Eric Granryd 《International Journal of Refrigeration》2004,27(7):761-773
Independently of the choice of refrigerant, environmental and or safety issues can be minimised by reducing the amount of refrigerant charge per heat pump or refrigeration system. In the investigation reported here, a laboratory test rig was built, simulating a water-to-water heat pump with a heating capacity of 5 kW. The system was designed to minimize the charge of refrigerant mainly by use of mini-channel aluminium heat exchangers. It was shown that the system could be run with 200 g of propane at typical Swedish operating conditions without reduction of the COP compared to a traditional design. Additional charge reduction is possible by selecting proper compressor lubrication oils or by using a compressor with less lubrication oil. 相似文献
59.
In this paper, we attempt to show how phenomenology, in a traditional methodological form, can provide an interesting and novel basis for thinking about screens in a world where screens now pervade a great many aspects of human experience. In our analysis, we aim to give a phenomenological account of screen(ing), that is, of its fundamental and foundational meaning. In doing the phenomenological analysis, we ground our argument on the ontology of Heidegger's Being and Time. In doing this, we claim that the screen will only show itself, as that which it is, as a screen in-the-world, where screens already are or have their being ‘as screens’ for this and that purpose, activity or work. We claim, and aim to show, that our analysis provides many insights about the meaning of screens that would be difficult to gain through any other method of investigation. We also argue and show that, although our method is not empirical, its results have important implications for the empirical world. 相似文献
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