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131.
Structures of the N-Terminal Domain of PqsA in Complex with Anthraniloyl- and 6-Fluoroanthraniloyl-AMP: Substrate Activation in Pseudomonas Quinolone Signal (PQS) Biosynthesis
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Florian Witzgall Wiebke Ewert Prof. Dr. Wulf Blankenfeldt 《Chembiochem : a European journal of chemical biology》2017,18(20):2045-2055
Pseudomonas aeruginosa, a prevalent pathogen in nosocomial infections and a major burden in cystic fibrosis, uses three interconnected quorum-sensing systems to coordinate virulence processes. At variance with other Gram-negative bacteria, one of these systems relies on 2-alkyl-4(1H)-quinolones (Pseudomonas quinolone signal, PQS) and might hence be an attractive target for new anti-infective agents. Here we report crystal structures of the N-terminal domain of anthranilate-CoA ligase PqsA, the first enzyme of PQS biosynthesis, in complex with anthraniloyl-AMP and with 6-fluoroanthraniloyl-AMP (6FABA-AMP) at 1.4 and 1.7 Å resolution. We find that PqsA belongs to an unrecognized subfamily of anthranilate-CoA ligases that recognize the amino group of anthranilate through a water-mediated hydrogen bond. The complex with 6FABA-AMP explains why 6FABA, an inhibitor of PQS biosynthesis, is a good substrate of PqsA. Together, our data might pave a way to new pathoblockers in P. aeruginosa infections. 相似文献
132.
Working memory (WM) declines prominently during normal aging. The mechanisms underlying this decline are not fully understood. The authors analyzed performance on 2 versions of a 2-back spatial WM task to assess younger and older adults' responses to lures (i.e., nontarget items that match an item earlier in the sequence but not at the current target lag). Results demonstrate lure interference effects that are particularly pronounced among older adults. At the same time, however, older adults showed facilitation for targets. Taken together, these findings suggest that the contribution of familiarity signals to WM performance increases during normal aging. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
133.
An electronic panel formed by an electronic nose, an electronic tongue and an electronic eye has been successfully used to evaluate the organoleptic characteristics of red wines vinified using different extraction techniques and micro-oxygenation methods and bottled using closures of different oxygen transmission rates (OTR). 相似文献
134.
Temperature Stability of Lead‐Free Niobate Piezoceramics with Engineered Morphotropic Phase Boundary
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Ruiping Wang Ke Wang Fangzhou Yao Jing‐Feng Li Florian H. Schader Kyle G. Webber Wook Jo Jürgen Rödel 《Journal of the American Ceramic Society》2015,98(7):2177-2182
The temperature dependence of piezoelectric properties (direct piezoelectric coefficient d33, converse piezoelectric coefficient d33(E = 0), strain S and electromechanical coupling coefficient kp) for two niobate‐based lead‐free piezoceramics have been contrasted. 0.92(Na0.5K0.5)NbO3–0.02(Bi1/2Li1/2)TiO3–0.06BaZrO3 (6BZ/2BLT/92NKN) has a morphotropic phase boundary (MPB) between rhombohedral and tetragonal at room temperature and 0.92(Na0.5K0.5)NbO3–0.03(Bi1/2Li1/2)TiO3–0.05BaZrO3 (5BZ/3BLT/92NKN) features an MPB engineered to be located below room temperature. At 30°C, d33, d33(E = 0), S (at 2 kV/mm), and kp are 252 pC/N, 230 pm/V, 0.069%, 0.51 for 5BZ/3BLT/92NKN; and 348 pC/N, 380 pm/V, 0.106%, 0.57 for 6BZ/2BLT/92NKN, respectively. With increasing temperature, the piezoelectric properties decrease. At 200°C, d33, d33(E = 0), S (at 2 kV/mm), and kp are 170 pC/N, 160 pm/V, 0.059%, 0.36 for 5BZ/3BLT/92NKN; and 181 pC/N, 190 pm/V, 0.061%, 0.39 for 6BZ/2BLT/92NKN. It is found that the electromechanical coupling coefficient has a better temperature stability than the piezoelectric coefficient in the studied system due to a large temperature‐dependent compliance change. The results demonstrate that engineering an MPB is highly effective in tailoring temperature stability of piezoceramics. 相似文献
135.
Highly Crystalline Films of PCPDTBT with Branched Side Chains by Solvent Vapor Crystallization: Influence on Opto‐Electronic Properties
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136.
Csaba M. Jzsa Gza Kolumbn Antonio M. Vidal Francisco J. Martínez‐Zaldívar Alberto Gonzlez 《Concurrency and Computation》2015,27(17):4993-5018
Multiple‐input multiple‐output (MIMO) systems have attracted considerable attention in wireless communications because they offer a significant increase in data throughput and link coverage without additional bandwidth requirement or increased transmit power. The price that has to be paid is the increased complexity of hardware components and algorithms. The sphere detector (SD) algorithm solves the problem of maximum likelihood (ML) detection for MIMO channels by significantly reducing the search space of possible solutions. The main drawback of the SD algorithm is in its sequential nature, consequently, running it on massively parallel architectures (MPAs) is very inefficient. In order to overcome the drawbacks of the SD algorithm, a new parallel sphere detector (PSD) algorithm is proposed. It implements a novel hybrid tree search method, where the algorithm parallelism is assured by the efficient combination of depth‐first search and breadth‐first search algorithms. A path metric‐based parallel sorting is employed at each intermediate stage. The PSD algorithm is able to adjust its memory requirements and extent of parallelism to fit a wide range of parallel architectures. Mapping details for MPAs are proposed by giving the details of thread dependent, highly parallel building blocks of the algorithm. Based on the building blocks proposed, a mapping to general‐purpose graphics processing unit is provided, and its performance is evaluated. In order to achieve high‐throughput, several levels of parallelism are introduced, and different scheduling strategies are considered. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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Bjoern Titz Karsta Luettich Patrice Leroy Stephanie Boue Gregory Vuillaume Terhi Vihervaara Kim Ekroos Florian Martin Manuel C. Peitsch Julia Hoeng 《International journal of molecular sciences》2016,17(9)
Smoking is a major risk factor for several diseases including chronic obstructive pulmonary disease (COPD). To better understand the systemic effects of cigarette smoke exposure and mild to moderate COPD—and to support future biomarker development—we profiled the serum lipidomes of healthy smokers, smokers with mild to moderate COPD (GOLD stages 1 and 2), former smokers, and never-smokers (n = 40 per group) (ClinicalTrials.gov registration: ). Serum lipidome profiling was conducted with untargeted and targeted mass spectrometry-based lipidomics. Guided by weighted lipid co-expression network analysis, we identified three main trends comparing smokers, especially those with COPD, with non-smokers: a general increase in glycero(phospho)lipids, including triglycerols; changes in fatty acid desaturation (decrease in ω-3 polyunsaturated fatty acids, and an increase in monounsaturated fatty acids); and an imbalance in eicosanoids (increase in 11,12- and 14,15-DHETs (dihydroxyeicosatrienoic acids), and a decrease in 9- and 13-HODEs (hydroxyoctadecadienoic acids)). The lipidome profiles supported classification of study subjects as smokers or non-smokers, but were not sufficient to distinguish between smokers with and without COPD. Overall, our study yielded further insights into the complex interplay between smoke exposure, lung disease, and systemic alterations in serum lipid profiles. NCT01780298相似文献