Tail-equivalent linearization method for nonlinear random vibration

A new, non-parametric linearization method for nonlinear random vibration analysis is developed. The method employs a discrete representation of the stochastic excitation and concepts from the first-order reliability method, FORM. For a specified response threshold of the nonlinear system, the equivalent linear system is defined by matching the “design points” of the linear and nonlinear responses in the space of the standard normal random variables obtained from the discretization of the excitation. Due to this definition, the tail probability of the linear system is equal to the first-order approximation of the tail probability of the nonlinear system, this property motivating the name Tail-Equivalent Linearization Method (TELM). It is shown that the equivalent linear system is uniquely determined in terms of its impulse response function in a non-parametric form from the knowledge of the design point. The paper examines the influences of various parameters on the tail-equivalent linear system, presents an algorithm for finding the needed sequence of design points, and describes methods for determining various statistics of the nonlinear response, such as the probability distribution, the mean level-crossing rate and the first-passage probability. Applications to single- and multi-degree-of-freedom, non-degrading hysteretic systems illustrate various features of the method, and comparisons with results obtained by Monte Carlo simulations and by the conventional equivalent linearization method (ELM) demonstrate the superior accuracy of TELM over ELM, particularly for high response thresholds.     

GaN‐based high‐output‐power blue laser diodes for display applications

Abstract— We succeeded in fabricating high‐output‐power blue (445 nm) laser diodes (LDs) with an output power of 500 mW. The operating current, voltage, and wall‐plug efficiency of these LDs were 480 mA, 4.8 V, and 21.7%, respectively. The lifetime of these LDs was estimated to be 10,000 hours under continuous‐wave operation at 25°C. From examination of the degradation mode, we found that the operating current seriously affects the lifetime of LDs. In the next stage, we will focuse on the optimization and sophistication of the manufacturing processes to fabricate longer‐lifetime (>30,000 hours) blue LDs.     

In-situ high temperature X-ray diffraction study of Ni/Al2O3 interface reactions

In-situ experiments on the Ni/Al₂O₃ interface reaction were carried out with a high temperature X-ray diffractometer capable of measuring the X-ray diffraction pattern in 1–2 s using an imaging plate. The kinetic formation processes of the interface reaction layer were measured by short-period exposure experiments with a high temperature X-ray diffractometer. NiAl₂O₄ was formed at the Ni/Al₂O₃ interface from 1468 K to 1673 K in air. The formation of NiAl₂O₄ obeyed the parabolic rate law. The value of the activation energy suggests that the diffusion of Al through NiAl₂O₄ controls the rate of formation. The results of thermal expansion coefficient measurements suggest that when a sample is cooled to room temperature, the magnitude of the stress on the Al₂O₃ owing to NiAl₂O₄ is smaller than that caused by NiO.     

Influence of antiferromagnetic ordering on ferroelectric polarization switching of YMnO3 epitaxial thin films

In this study, the switching behavior of ferroelectric polarization of (0001) YMnO(3) epitaxial films at around Néel temperature was investigated. From the experimental results of the frequency and temperature dependences of coercive electric filed (E(c)) obtained from polarization-electric field (P-E) hysteresis loop, the crosscorrelation phenomena between magnetics and ferroelectrics are discussed in detail. The P-E hysteresis loops of the films were measured in the frequency range from 1 Hz to 10 kHz, and the temperature was varied from 10 to 150 K. Frequency dependence of Ec accorded with Ishibashi-Orihara's theory at the measured temperature range. However, temperature dependence of E(c) disagreed with Devonshire's theory below 120 K, which is close to the Néeel temperature of the YMnO(3) epitaxial film. disagreed with Devonshire's theory below 120 K, which is close to the Neel temperature of the YMnO(3) epitaxial film.     

Beef texture characterization using internationally established texture vocabularies in ISO5492:1992: Differences among four different end-point temperatures in three muscles of Holstein steers

‘Tenderness’ has been an important sensory characteristic for beef, although ‘tenderness’ has not been commonly defined. On the other hand, ISO5492:1992 provides internationally established vocabularies for sensory analysis with simple definition. The aim of this study was texture characterization for three beef muscles cooked to four end-point temperatures using ISO5492:1992 texture terms in Japanese to develop objective sensory evaluation terms for beef texture other than ‘tenderness.’ Longissimus, semitendinosus, and psoas major muscles harvested from three Holstein steers were cooked to 45, 60, 72, and 92 °C end-point temperatures and evaluated by a trained sensory panel. Correspondence analysis indicated that the ‘chewiness’ and ‘hardness’ defined in ISO5492 were distinguished in each muscle. Changes in the ‘chewiness’ and ‘hardness’ qualities during cooking were different from each other. These findings suggest that both ‘chewiness’ and ‘hardness’ as defined in ISO5492:1992 should be evaluated simultaneously to determine the sensory texture of beef.     

Primary structure of two-chain botrocetin, a von Willebrand factor modulator purified from the venom of Bothrops jararaca

The complete amino acid sequence and location of the disulfide bonds of two-chain botrocetin, which promotes platelet agglutination in the presence of von Willebrand factor, from venom of the snake Bothrops jararaca are presented. Sequences of the alpha and beta subunits were determined by analysis of peptides generated by digestion of the S-pyridylethylated protein with Achromobacter protease I or alpha-chymotrypsin and by chemical cleavage with cyanogen bromide or 2-(2'-nitrophenylsulfenyl)-3-methyl-3-bromoindolenine. Two-chain botrocetin is a heterodimer composed of the alpha subunit (consisting of 133 amino acid residues) and the beta subunit (consisting of 125 amino acid residues) held together by a disulfide bond. Seven disulfide bonds link half-cystine residues 2 to 13, 30 to 128, and 103 to 120 of the alpha subunit; 2 to 13, 30 to 121, and 98 to 113 of the beta subunit; and 80 of the alpha subunit to 75 of the beta subunit. In terms of amino acid sequence and disulfide bond location, two-chain botrocetin is homologous to echinoidin (a sea urchin lectin) and other C-type (Ca(2+)-dependent) lectins.     

Cellular Conditions Responsible for Methylmercury-Mediated Neurotoxicity

Methylmercury (MeHg) is a widely known environmental pollutant that causes severe neurotoxicity. MeHg-induced neurotoxicity depends on various cellular conditions, including differences in the characteristics of tissues and cells, exposure age (fetal, childhood, or adulthood), and exposure levels. Research has highlighted the importance of oxidative stress in the pathogenesis of MeHg-induced toxicity and the site- and cell-specific nature of MeHg-induced neurotoxicity. The cerebellar granule cells and deeper layer cerebrocortical neurons are vulnerable to MeHg. In contrast, the hippocampal neurons are resistant to MeHg, even at high mercury accumulation levels. This review summarizes the mechanisms underlying MeHg-mediated intracellular events that lead to site-specific neurotoxicity. Specifically, we discuss the mechanisms associated with the redox ability, neural outgrowth and synapse formation, cellular signaling pathways, epigenetics, and the inflammatory conditions of microglia.     

Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain

Methylmercury (MeHg), an environmental toxicant, induces neuronal cell death and injures specific areas of the brain. MeHg is known to induce oxidative and endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) pathway has a dual nature in that it regulates and protects cells from an overload of improperly folded proteins in the ER, whereas excessively stressed cells are eliminated by apoptosis. Oxidative stress/ER stress induced by methylmercury exposure may tilt the UPR toward apoptosis, but there is little in vivo evidence of a direct link to actual neuronal cell death. Here, by using the ER stress-activated indicator (ERAI) system, we investigated the time course signaling alterations of UPR in vivo in the most affected areas, the somatosensory cortex and striatum. In the ERAI-Venus transgenic mice exposed to MeHg (30 or 50 ppm in drinking water), the ERAI signal, which indicates the activation of the cytoprotective pathway of the UPR, was only transiently enhanced, whereas the apoptotic pathway of the UPR was persistently enhanced. Furthermore, detailed analysis following the time course showed that MeHg-induced apoptosis is strongly associated with alterations in UPR signaling. Our results suggest that UPR modulation could be a therapeutic target for treating neuropathy.