Controlling the drying process in vacuum foam drying under low vacuum conditions by inducing foaming by needle stimulation of the solution

Abstract

Vacuum foam drying is a promising drying technique but an extremely high vacuum is needed to achieve “foaming.” The findings reported herein show that, when a solution is partially vacuum-dried to 0.05–2?g-solvent/g-dry matter (initial drying) and the solution is then punctured with a steel needle (needle stimulation), vacuum drying resumes as a result of the solution foaming, even under conditions of an insufficient vacuum (ca. 1,000?Pa) where foaming is minimal. Methanol, ethanol, and isopropanol were used as solvents, and sugar and different molecular weight polyvinylpyrrolidone were employed as solutes. The results indicate that needle puncturing introduces minute bubbles, which then triggers foaming.     

Evaluation of Anti-Inflammatory Drug-Conjugated Silicon Quantum Dots: Their Cytotoxicity and Biological Effect

Silicon quantum dots (Si-QDs) have great potential for biomedical applications, including their use as biological fluorescent markers and carriers for drug delivery systems. Biologically inert Si-QDs are less toxic than conventional cadmium-based QDs, and can modify the surface of the Si-QD with covalent bond. We synthesized water-soluble alminoprofen-conjugated Si-QDs (Ap-Si). Alminoprofen is a non-steroid anti-inflammatory drug (NSAID) used as an analgesic for rheumatism. Our results showed that the “silicon drug” is less toxic than the control Si-QD and the original drug. These phenomena indicate that the condensed surface integration of ligand/receptor-type drugs might reduce the adverse interaction between the cells and drug molecules. In addition, the medicinal effect of the Si-QDs (i.e., the inhibition of COX-2 enzyme) was maintained compared to that of the original drug. The same drug effect is related to the integration ratio of original drugs, which might control the binding interaction between COX-2 and the silicon drug. We conclude that drug conjugation with biocompatible Si-QDs is a potential method for functional pharmaceutical drug development.     

A fire danger rating system for Hawaii

Extremes in rainfall on the Hawaiian Islands make it difficult to judge forest fire danger conditions. The use of an automatic data collection and computer processing system helps to monitor the problem. Note: Messrs. Burgan and Fujioka are on the staff of the Pacific Southwest Forest and Range Experiment Station, Forest Service, U. S. Department of Agriculture. Mr. Hirata is with the National Weather Service. All three are stationed at Honolulu, Hawaii.