Absence of tonic electromyographic activity during sleep in normal and spastic nonmimetic skeletal muscles in man

An electromyographic study of nonmimetic skeletal muscles was carried out in 8 normal adults and 4 patients with spastic hemiparesis during all stages of sleep for a total of 21 nights. All normal subjects showed absence of tonic electromyographic activity in all nonmimetic skeletal muscles in all stages of sleep. Also, during quiet, relaxed wakefulness, tonic muscle discharges disappeared in the normal subjects. Three patients with upper motor neuron spasticity demonstrated results during sleep similar to those obtained in the normal subjects. In the fourth patient, tonic muscle discharges persisted into stage 2 non-REM sleep, disappeared within 30 to 240 seconds following the onset of stage 2 sleep, and were absent during stages 3 and 4 sleep and REM sleep.     

Thyroid carcinoma after high-dose external radiotherapy for Hodgkin's disease: report of three cases

Three patients (two female and one male), who had received mantle irradiation for Hodgkin's disease eight, ten, and twelve years previously, developed papillary thyroid carcinoma. The radiation doses to the necks overlying the site of thyroid cancers were 3000, 4000, and 4100 rads, respectively. It has been stated that there is no risk of developing thyroid cancer with such high doses of external irradiation but apparently this complication will be encountered in a small number of patients.     

Granulated activated carbon modified with hydrophobic silica aerogel-potential composite materials for the removal of uranium from aqueous solutions

Aqueous solutions of 100 parts per billion (ppb) uranium at pH 7 were treated with granulated activated carbon (GAC) that had been modified with various formulations of hydrophobic aerogels. The composite materials were found to be superior in removing uranium from a stock solution compared to GAC alone evaluated by a modified ASTM D 3860-98 method for batch testing. The testing results were evaluated using a Freundlich adsorption model. The best performing material has parameters of n = 287 and Kf = 1169 compared to n = 1.00, and Kf = 20 for GAC alone. The composite materials were formed by mixing (CH3O)4Si with the hydrophobic sol-gel precursor, (CH3O)3SiCH2CH2CF3 and with specified modifiers, such as H3PO4, Ca(NO3)2, and (C2H5O)3SiCH2CH2P(O)(OC2H5)2, elation catalysts, and GAC in a supercritical reactor system. After gelation, supercritical extraction, and sieving, the composites were tested. Characterization by FTIR and 31P NMR indicate the formation of phosphate in the case of the H3PO4 and Ca(NO3)2 composites and phosphonic acid related compounds in the phosphonate composite. These composite materials have potential application in the clean up of groundwater at DOE and other facilities.     

Two-phase flow regimes in round, square and rectangular tubes during condensation of refrigerant R134a

An experimental investigation of two-phase flow mechanisms during condensation of refrigerant R134a in six small diameter round (4.91 mm), square (D_h=4 mm, α=1), and rectangular (4×6 and 6×4 mm: D_h=4.8 mm, α=0.67 and 1.5; 2×4 and 4×2 mm: D_h=2.67 mm, α =0.5 and 2) was conducted. Unique experimental techniques and test sections were developed to enable the documentation of the flow mechanisms during phase change. For each tube under consideration, flow mechanisms were recorded over the entire range of qualities for five different refrigerant mass fluxes between 150 and 750 kg m⁻² s⁻¹. The flow mechanisms were categorized into four different flow regimes: intermittent flow, wavy flow, annular flow, and dispersed flow. In addition, the large amount of data enabled the delineation of several different flow patterns within each flow regime, which provides a clearer understanding of the different modes of two-phase flow. Transition lines between the respective flow patterns and regimes on these maps were established based on the experimental data. It was found that for similar hydraulic diameters, flow regime transitions are not very strongly dependent on tube shape or aspect ratio. These maps and the transition lines can be used to predict the particular flow pattern or regime that will be established for a given mass flux, quality and tube geometry.     

Induced maturation of frog mast cells by nerve growth factor during ontogenesis

The effect of nerve growth factor (NGF) on ontogenesis of frog mast cells was investigated in vivo by histochemical, morphometric, and ultrastructural analysis. Three groups of tadpoles at various stages of development were used. In the first group, the larvae received i.p. injections of 1 ng NGF/g; the second group received 10 ng NGF/g, while the control group received only the vehicle. The first recognizable mast cells arose symmetrically in the tongue at stage 26 of Witschi's standard table. At stages 26 and 29, the mast cell number in the NGF-injected tadpoles was significantly higher than the control group. From stage 29 onward, the mast cell number rapidly increased in all groups. No significant differences in mast cell number were observed between the control group and the NGF-injected groups at stages 31 and 33. Electron microscopy revealed that at metamorphic climax (stage 33), the mast cells in the NGF-treated groups were more mature than those in the control group. Therefore, nerve growth factor at early stages of tadpole development is likely to induce differentiation of mast cell precursors, while at later stages it is likely to induce maturation of immature mast cells. The close anatomical association between mast cells and perineurium, observed during nerve development, is intriguing. Already in the early stages of nerve development, the mast cells form a network around Schwann cell-axon complexes, together with the perineurial cells. At climax, the mast cells are located between the perineurial layers, suggesting that they may play a role in the tissue-nerve barrier of the perineurium. Nerve growth factor also seems to induce perineurial cell maturation.     

Subelement Form-Drag Parameterization in Rough-Bed Flows

Spatial averaging of the Reynolds-averaged Navier–Stokes equations gives the double-averaged Navier–Stokes equations, for which boundary drag appears naturally and explicitly in momentum conservation equations. Increasing use of the double-averaged equations, e.g., for relating flows to three-dimensional bed roughness, for evaluation of profiles of flow stresses and velocities in ecologically significant regions below roughness tops, and for modeling purposes, requires parameterization of boundary drag at subelement scales. Based on seven flows over repeated square-rib roughness and ten flows over repeated fixed simulated sand waves, with measured velocities and bed pressures, expressions for form-drag coefficient CD = f (elevation below roughness top, relative roughness submergence, roughness steepness) are obtained for each of the two-dimensional roughness types. Using these equations, form drag variation with elevation below roughness tops can be calculated using either the double average of the square of local velocity (preferred based on conceptual considerations, trends in coefficient prediction, and also overall drag prediction) or the squared local double-averaged velocity, the roughness area being normal to the flow in each case. Integration of subelement drag given by these expressions is shown to give form-drag coefficient magnitudes and trends for complete individual elements comparable to those obtained by other authors based on measurements or numerical simulations. The ranges of roughness steepness and relative roughness submergence upon which the present equations have been derived need to be noted in consideration of application of the equations. In addition, effective application of the expressions is limited in regions of strongly negative double-averaged velocity. Further work remains to determine drag parameterization for alternative roughness geometries.     

Production of Two‐Dimensional Nanomaterials via Liquid‐Based Direct Exfoliation

Tremendous efforts have been devoted to the synthesis and application of two‐dimensional (2D) nanomaterials due to their extraordinary and unique properties in electronics, photonics, catalysis, etc., upon exfoliation from their bulk counterparts. One of the greatest challenges that scientists are confronted with is how to produce large quantities of 2D nanomaterials of high quality in a commercially viable way. This review summarizes the state‐of‐the‐art of the production of 2D nanomaterials using liquid‐based direct exfoliation (LBE), a very promising and highly scalable wet approach for synthesizing high quality 2D nanomaterials in mild conditions. LBE is a collection of methods that directly exfoliates bulk layered materials into thin flakes of 2D nanomaterials in liquid media without any, or with a minimum degree of, chemical reactions, so as to maintain the high crystallinity of 2D nanomaterials. Different synthetic methods are categorized in the following, in which material characteristics including dispersion concentration, flake thickness, flake size and some applications are discussed in detail. At the end, we provide an overview of the advantages and disadvantages of such synthetic methods of LBE and propose future perspectives.     

The implementation of a cell-based manufacturing system

This paper describes the development of a cell-based manufacturing system. It considers all aspects of the implementation: the initial analysis of the problems of an existing system, product redesign for manufacture, cell design and cell implementation. The effectiveness of the resulting system is measured, using quantitative parameters. These include manufacturing lead times, due date performance and inventory levels. Other features, such as increased product quality, increased customer satisfaction and increased worker satisfaction, which cannot be measured easily, are discussed and shown to be major factors behind the successful implementation. Although presented as a case study the procedures adopted to facilitate the successful implementation are of general interest to any prospective manufacturing cell user.     

A Comparative Study of the Use of Visual Communicative Signals in Interactions Between Dogs (Canis familiaris) and Humans and Cats (Felis catus) and Humans.

Dogs' (Canis familiaris) and cats' (Felis catus) interspecific communicative behavior toward humans was investigated. In Experiment 1, the ability of dogs and cats to use human pointing gestures in an object-choice task was compared using 4 types of pointing cues differing in distance between the signaled object and the end of the fingertip and in visibility duration of the given signal. Using these gestures, both dogs and cats were able to find the hidden food; there was no significant difference in their performance. In Experiment 2, the hidden food was made inaccessible to the subjects to determine whether they could indicate the place of the hidden food to a naive owner. Cats lacked some components of attention-getting behavior compared with dogs. The results suggest that individual familiarization with pointing gestures ensures high-level performance in the presence of such gestures; however, species-specific differences could cause differences in signaling toward the human. (PsycINFO Database Record (c) 2010 APA, all rights reserved)