Apparatus for real-time measurement of particle size distribution

In this paper we describe an apparatus for real-time measurement of particle size distribution. By introducing a fast moving water stream with suspended particles and stroboscopic illumination, a large number of pictures (samples) can be analysed by means of a TV camera connected to a computer. In this manner complete particle size distribution is achieved with minimal delay. Satisfactory results were obtained when the apparatus was tested as an on-line device in a flotation plant, demonstrating the full ability of the system to control the flotation process.     

Finite rotations in the description of continuum deformation

Finite rotations in continuum mechanics are described by means of either a proper orthogonal tensor or finite rotation vectors. Some algebraic relations concerning the finite rotations are reviewed. Formulae expressing them in terms of displacements are given. Along each of the curvilinear coordinate lines the finite rotations are shown to satisfy some systems of the linear first-order differential equations. Each system of the equations is presented in four different but equivalent forms associated with an intermediate stretched basis or with an intermediate rotated basis. Integrability conditions of the system of equations provide various alternative forms of compatibility conditions in continuum mechanics. The displacement field is expressed through the stretch and rotation fields in the form of three successive line integrals. The formula describes the displacements to within a constant finite translation and a constant finite rotation. The procedure proposed here generalizes the formula derived by Cesàro (1906) within the classical linear theory of elasticity.     

Mathematical foundations of the quasistatic approximation in reactor physics

The quasistatic method used in reactor-physics calculations is applied to a model integro-differential equation in a Banach space. The resulting quasistatic equations are shown to be locally consistent with the original initial-value problem. An iterative scheme to solve these equations is presented and shown to be convergent.     

A modified creep model of epoxy adhesive at ambient temperature

The paper presents the results of experimental investigations of the creep behavior of epoxy adhesive-hardened samples. The determined creep characteristics for an assumed range of tensile stresses show that the rheological effects in the examined adhesive have already occurred very distinctly at room temperature, for a relatively short time; moreover, the examined adhesive is a nonlinear viscoelastic medium and does not obey the Boltzmann's superposition principle. The obtained results of experimental investigations were subjected to detailed analysis and mathematical treatments. As a result of these actions, the so-called modified Burgers model has been finally developed for the studied adhesive with a constant modulus of elasticity for the non-relaxing part (describing the instant elastic strain) and variables, dependent on the tensile stress, the parameter values for its relaxing part (describing non-linearly viscoelastic properties of this adhesive). The creep deformations calculated for this model have demonstrated a very good consistency with the results of experimental investigations over the assumed range of stresses and the duration time of measurements.     

Anti-Inflammatory Effect of Very High Dose Local Vessel Wall Statin Administration: Poly(L,L-Lactide) Biodegradable Microspheres with Simvastatin for Drug Delivery System (DDS)

Atherosclerosis involves an ongoing inflammatory response of the vascular endothelium and vessel wall of the aorta and vein. The pleiotropic effects of statins have been well described in many in vitro and in vivo studies, but these effects are difficult to achieve in clinical practice due to the low bioavailability of statins and their first-pass metabolism in the liver. The aim of this study was to test a vessel wall local drug delivery system (DDS) using PLA microstructures loaded with simvastatin. Wistar rats were fed high cholesterol chow as a model. The rat vessels were chemically injured by repeated injections of perivascular paclitaxel and 5-fluorouracil. The vessels were then cultured and treated by the injection of several concentrations of poly(L,L-lactide) microparticles loaded with the high local HMG-CoA inhibitor simvastatin (0.58 mg/kg) concentration (SVPLA). Histopathological examinations of the harvested vessels and vital organs after 24 h, 7 days and 4 weeks were performed. Microcirculation in mice as an additional test was performed to demonstrate the safety of this approach. A single dose of SVPLA microspheres with an average diameter of 6.4 μm and a drug concentration equal to 8.1% of particles limited the inflammatory reaction of the endothelium and vessel wall and had no influence on microcirculation in vivo or in vitro. A potent pleiotropic (anti-inflammatory) effect of simvastatin after local SVPLA administration was observed. Moreover, significant concentrations of free simvastatin were observed in the vessel wall (compared to the maximum serum level). In addition, it appeared that simvastatin, once locally administered as SVPLA particles, exerted potent pleiotropic effects on chemically injured vessels and presented anti-inflammatory action. Presumably, this effect was due to the high local concentrations of simvastatin. No local or systemic side effects were observed. This approach could be useful for local simvastatin DDSs when high, local drug concentrations are difficult to obtain, or systemic side effects are present.     

Green TPUs from Prepolymer Mixtures Designed by Controlling the Chemical Structure of Flexible Segments

This study concerns green thermoplastic polyurethanes (TPU) obtained by controlling the chemical structure of flexible segments. Two types of bio-based polyether polyols—poly(trimethylene glycol)s—with average molecular weights ca. 1000 and 2700 Da were used (PO3G1000 and PO3G2700, respectively). TPUs were prepared via a two-step method. Hard segments consisted of 4,4′-diphenylmethane diisocyanates and the bio-based 1,4-butanodiol (used as a chain extender and used to control the [NCO]/[OH] molar ratio). The impacts of the structure of flexible segments, the amount of each type of prepolymer, and the [NCO]/[OH] molar ratio on the chemical structure and selected properties of the TPUs were verified. By regulating the number of flexible segments of a given type, different selected properties of TPU materials were obtained. Thermal analysis confirmed the high thermal stability of the prepared materials and revealed that TPUs based on a higher amount of prepolymer synthesized from PO3G2700 have a tendency for cold crystallization. An increase in the amount of PO3G1000 at the flexible segments caused an increase in the tensile strength and decrease in the elongation at break. Melt flow index results demonstrated that the increase in the amount of prepolymer based on PO3G1000 resulted in TPUs favorable in terms of machining.     

Programmable Atom Equivalents: Atomic Crystallization as a Framework for Synthesizing Nanoparticle Superlattices

Decades of research efforts into atomic crystallization phenomenon have led to a comprehensive understanding of the pathways through which atoms form different crystal structures. With the onset of nanotechnology, methods that use colloidal nanoparticles (NPs) as nanoscale “artificial atoms” to generate hierarchically ordered materials are being developed as an alternative strategy for materials synthesis. However, the assembly mechanisms of NP‐based crystals are not always as well‐understood as their atomic counterparts. The creation of a tunable nanoscale synthon whose assembly can be explained using the context of extensively examined atomic crystallization will therefore provide significant advancement in nanomaterials synthesis. DNA‐grafted NPs have emerged as a strong candidate for such a “programmable atom equivalent” (PAE), because the predictable nature of DNA base‐pairing allows for complex yet easily controlled assembly. This Review highlights the characteristics of these PAEs that enable controlled assembly behaviors analogous to atomic phenomena, which allows for rational material design well beyond what can be achieved with other crystallization techniques.     

Compositions of solvent-extracts of a Polish bituminous coal

The compositions of acetone, tetrahydrofuran and pyridine extracts from a bituminous coal were studied using mass spectrometry and the main components were identified. The compositions of the extracts were similar, as predicted by the electron-donor-acceptor mechanism of coal extraction. Different extract yields are due mainly to differences in the fraction of high molecular weight components in the extracts.     

Studies on curing urethane prepolymers with aniline–formaldehyde resins

Commercial aniline–cresol–formaldehyde resin, two model aniline–formaldehyde and aniline–cresol–formaldehyde resins, and methylenedianiline have been used as curatives for NCO-terminated urethane prepolymer prepared from polyoxypropylenediol and toluene-diisocyanate. Based on viscoelastic behavior of the investigated systems and changes in their IR spectra, it has been concluded that phenolic OH groups present in aniline–cresol–formaldehyde resin do not play an important role in the curing process carried out at RT despite earlier suggestions to the contrary. The explanation for specific behavior of systems where urethane prepolymers have been cured with commercial aniline–cresol–formaldehyde resin is presumably the presence of small amount of solvent (benzyl alcohol) in that resin, which may influence the reaction kinetics.