Macrophage Membrane-Coated Nanoparticles Sensitize Glioblastoma to Radiation by Suppressing Proneural–Mesenchymal Transformation in Glioma Stem Cells

Radiotherapy is identified as a crucial treatment for patients with glioblastoma, but recurrence is inevitable. The efficacy of radiotherapy is severely hampered partially due to the tumor evolution. Growing evidence suggests that proneural glioma stem cells can acquire mesenchymal features coupled with increased radioresistance. Thus, a better understanding of mechanisms underlying tumor subclonal evolution may develop new strategies. Herein, data highlighting a positive correlation between the accumulation of macrophage in the glioblastoma microenvironment after irradiation and mesenchymal transdifferentiation in glioblastoma are presented. Mechanistically, elevated production of inflammatory cytokines released by macrophages promotes mesenchymal transition in an NF-κB-dependent manner. Hence, rationally designed macrophage membrane-coated porous mesoporous silica nanoparticles (MMNs) in which therapeutic anti-NF-κB peptides are loaded for enhancing radiotherapy of glioblastoma are constructed. The combination of MMNs and fractionated irradiation results in the blockage of tumor evolution and therapy resistance in glioblastoma-bearing mice. Intriguingly, the macrophage invasion across the blood-brain barrier is inhibited competitively by MMNs, suggesting that these nanoparticles can fundamentally halt the evolution of radioresistant clones. Taken together, the biomimetic MMNs represent a promising strategy that prevents mesenchymal transition and improves therapeutic response to irradiation as well as overall survival in patients with glioblastoma.     

Study of delay-independent decentralized guaranteed cost control for large scale systems

This study introduces delay independent decentralized guaranteed cost control design method based on two controller structures for nonlinear uncertain interconnected large scale systems with time delays. First, a set of equivalent Takagi-Sugeno (T-S) fuzzy models are extended to represent the systems. Then a decentralized state-feedback guaranteed cost performance controller is proposed for the fuzzy systems. Based on delay independent Lyapunov functional approach, some sufficient conditions for the existence of the controller can be cast into the feasible problem of LMIs irrespective of the sizes of the time delays so that the system can be asymptotically stabilized for all considered uncertainties whose sizes are not larger than their bounds. Finally, the minimizing approach is proposed to search the suboptimal upper bound value of guaranteed cost function. Moreover, the corresponding conditions are extended into the generalized dynamic output-feedback close-loop system. Finally, the better control performances of the proposed methods are shown by the simulation examples.     

Stabilization of linear systems with input delay and saturation—A parametric Lyapunov equation approach

This paper studies the problem of stabilizing a linear system with delayed and saturating feedback. It is known that the eigenstructure assignment‐based low‐gain feedback law (globally) stabilizes a linear system in the presence of arbitrarily large delay in its input, and semi‐globally stabilizes it when the input is also subject to saturation, as long as all its open‐loop poles are located in the closed left‐half plane. Based on a recently developed parametric Lyapunov equation‐based low‐gain feedback design method, this paper presents alternative, but simpler and more elegant, feedback laws that solve these problems. The advantages of this new approach include its simplicity, the capability of giving explicit conditions to guarantee the stability of the closed‐loop system, and the ease in scheduling the low‐gain parameter on line to achieve global stabilization in the presence of actuator saturation. Copyright © 2009 John Wiley & Sons, Ltd.     

Structure damage diagnosis using neural network and feature fusion

A structure damage diagnosis method combining the wavelet packet decomposition, multi-sensor feature fusion theory and neural network pattern classification was presented. Firstly, vibration signals gathered from sensors were decomposed using orthogonal wavelet. Secondly, the relative energy of decomposed frequency band was calculated. Thirdly, the input feature vectors of neural network classifier were built by fusing wavelet packet relative energy distribution of these sensors. Finally, with the trained classifier, damage diagnosis and assessment was realized. The result indicates that, a much more precise and reliable diagnosis information is obtained and the diagnosis accuracy is improved as well.     

Performance-First Control for Discrete-Time LQG Problems

Performance-first control for discrete-time LQG is considered in this paper to minimize the probability that the performance index exceeds a preselected threshold via constructing a closed-loop feedback control law. This problem can be converted into a mean-variance control problem which can be solved by developing a nested form of the variance and using polynomial optimization as a solution scheme.     

Reachability determination in acyclic Petri nets by cell enumeration approach

Reachability is one of the most important behavioral properties of Petri nets. We propose in this paper a novel approach for solving the fundamental equation in the reachability analysis of acyclic Petri nets, which has been known to be NP-complete. More specifically, by adopting a revised version of the cell enumeration method for an arrangement of hyperplanes in discrete geometry, we develop an efficient solution scheme to identify firing count vector solution(s) to the fundamental equation on a bounded integer set, with a complexity bound of O((nu)^n−m), where n is the number of transitions, m is the number of places and u is the upper bound of the number of firings for all individual transitions.     

电子商务安全隐患及其对策

分析了电子商务的安全需求、面临的主要安全问题,并在对入侵行为进行分类研究的基础上,对电子商务活动流程的描述和脆弱点分析中研究了其安全对策.     

Robust guaranteed cost control for singular Markovian jump systems with time-varying delay

This paper is concerned with the guaranteed cost control for continuous-time singular Markovian jump systems with time-varying delay. Without using the free weighting matrices method, a delay-range-dependent condition is derived in terms of strict linear matrix inequality (LMI), which guarantees that the singular system is regular, impulse free and mean-square exponentially stable with an H(∞) performance. Based on this, the existence condition of the guaranteed cost state feedback controller is proposed. A numerical example is given to illustrate the effectiveness and less conservatism of the proposed design method.