Parthenium sp. as a plant biomass for the production of alkalitolerant xylanase from mutant Penicillium oxalicum SAUE-3.510 in submerged fermentation

The use of congress grass (Parthenium sp.) and water hyacinth (Eichhornia crassipes) as low cost raw materials for xylanase production from mutant Penicillium oxalicum SAU_E-3.510 in submerged fermentation was investigated. For development of mutant from wild type P. oxalicum SA-8 ITCC 6024, a strategy of mixed mutagenesis was followed using UV-irradiation and ethidium bromide, which had resulted into 1.87 fold increases in the activity of the enzyme. For enzyme production, the fungus was cultivated in mineral medium containing congress grass as carbon source. Considerably higher levels of production (475.2 ± 6.0 IU ml^?1) were achieved in media containing congress grass, although it was slightly less than that was obtained (488.5 ± 6.5 IU ml^?1) in presence of commercial oat spelt xylan. This fact confirms the feasibility of using this low cost non-food resource as an alternative carbon source to save costs of the enzyme production process. Maximum xylanase activity was reported at 55 °C with its stability at 80 °C for 2 h. The highest activity of xylanase at pH 9.0 and its stability at similar pH for 24 h denote the alkalitolerant nature of enzyme.     

Enhanced Electrostatics for Low-Voltage Operations in Nanocrystal Based Nanotube/Nanowire Memories

The metal nanocrystal (NC)/carbon nanotube (CNT) based nonvolatile memory has been proposed recently in comparison to the microfabricated Si channel and Si NCs in ultranarrow channel structure. The electrostatics of metal NC-CNT devices during memory operations differ significantly from the metal NC memory with planar silicon channel. In this paper, we present the theoretical analysis on the three-dimensional (3-D) electrostatics of the NC-CNT device during memory operations, to illustrate the experimentally observed large number of charge storage at low gate bias (5 V) despite a 100-nm-thick bottom-gate control dielectric. NCs are electrostatically more strongly coupled to the two-dimensional (2-D) gate electrode than to the one-dimensional (1-D) channel, even when the NCs are in much closer proximity to the 1-D channel, for efficient tunneling and low-voltage program operation. Under the retention condition, the NC-CNT devices have lower electric field across tunneling oxide than that in the case of a 2-D channel. This increasing electric field difference with respect to program versus retention operations indicates larger ratio between program and retention times. Together with the large number of electrons stored per NC, this enhanced electrostatics can be utilized either to reduce the operating voltage or to reduce statistical fluctuation of the information storage     

Eave Ice Dams

Water seepage into interior spaces and the resultant staining of wall and/or ceiling surfaces is a common problem with eave ice dams. If the outdoor temperature is below freezing, the roof is poorly insulated, and if the roof snow layer is thick enough, the temperature at the bottom of the snow will be at freezing. A portion of the thermal energy goes into melting some of the roof snow, that is, meltwater is generated which flows downslope toward the eaves. Some of the meltwater refreezes at the cold eave, forming an ice dam. The potential for water seepage is related to the horizontal extent of the ice dam. Mitigation usually involves placing an impermeable “ice and snow guard” layer for some distance from the eave. This paper presents information on the horizontal extent of expected eave ice dams with various returns period for 15 U.S. cities. In addition a correlation between ice dam size and the 50-year ground snow load is presented which allows one to estimate ice dam size for any U.S. city.     

Book Reviews

Abstract:

Disruptive technology can be defined as an emerging technology whose arrival in the marketplace signifies the eventual displacement of the dominant technology in that sector. Defining and assessing a set of key metrics for a disruptive technology at its early stages can substantially aid an enterprise to develop requirements, identify, and in turn increase the possibility of the successful launch of a disruptive technology. This article aims at defining a set of key metrics for evaluation of a possible disruptive technology. A case study is subsequently used for demonstrating the metrics identified. The article concludes with its relevance to the engineering management domain and directions for future research.     

Intrinsically disordered proteins in a physics-based world

Intrinsically disordered proteins (IDPs) are a newly recognized class of functional proteins that rely on a lack of stable structure for function. They are highly prevalent in biology, play fundamental roles, and are extensively involved in human diseases. For signaling and regulation, IDPs often fold into stable structures upon binding to specific targets. The mechanisms of these coupled binding and folding processes are of significant importance because they underlie the organization of regulatory networks that dictate various aspects of cellular decision-making. This review first discusses the challenge in detailed experimental characterization of these heterogeneous and dynamics proteins and the unique and exciting opportunity for physics-based modeling to make crucial contributions, and then summarizes key lessons from recent de novo simulations of the structure and interactions of several regulatory IDPs.     

The rates of charge separation and energy destructive charge recombination processes within an organic dyad in presence of metal-semiconductor core shell nanocomposites

Steady state and time resolved spectroscopic measurements were made at the ambient temperature on an organic dyad, 1-(4-Chloro-phenyl)-3-(4-methoxy-naphthalen-1-yl)-propenone (MNCA), where the donor 1-methoxynaphthalene (1 MNT) is connected with the acceptor p-chloroacetophenone (PCA) by an unsaturated olefinic bond, in presence of Ag@TiO2 nanoparticles. Time resolved fluorescence and absorption measurements reveal that the rate parameters associated with charge separation, k(CS), within the dyad increases whereas charge recombination rate k(CR) reduces significantly when the surrounding medium is changed from only chloroform to mixture of chloroform and Ag@TiO2 (noble metal-semiconductor) nanocomposites. The observed results indicate that the dyad being combined with core-shell nanocomposites may form organic-inorganic nanocomposite system useful for developing light energy conversion devices. Use of metal-semiconductor nanoparticles may provide thus new ways to modulate charge recombination processes in light energy conversion devices. From comparison with the results obtained in our earlier investigations with only TiO2 nanoparticles, it is inferred that much improved version of light energy conversion device, where charge-separated species could be protected for longer period of time of the order of millisecond, could be designed by using metal-semiconductor core-shell nanocomposites rather than semiconductor nanoparticles only.