Analysis of tubular structures in three-dimensional confocal images

Knowledge about the relationship between morphology and the function of neurons is an important instrument in understanding the role that neurons play in information processing in the brain. In paricular, the diameter and length of segments in dendritic arborization are considered to be crucial morphological features. Consequently, accurate detection of morphological features such as centre line position and diameter is a prerequisite to establish this relationship. Accurate detection of neuron morphology from confocal microscope images is hampered by the low signal to noise ratio of the images and the properties of the microscope point spread function (PSF). The size and the anisotropy of the PSF causes feature detection to be biased and orientation dependent. We deal with these problems by utilizing Gaussian image derivatives for feature detection. Gaussian kernels provide for image derivative estimates with low noise sensitivity. Features of interest such as centre line positions and diameter in a tubular neuronal segment of a dendritic tree can be detected by calculating and subsequently utilizing Gaussian image derivatives. For diameter measurement the microscope PSF is incorporated into the derivative calculation. Results on real and simulated confocal images reveal that centre line position and diameter can be estimated accurately and are bias free even under realistic imaging conditions.     

New competitive results for the stochastic resource-constrained project scheduling problem: exploring the benefits of pre-processing

We study the resource-constrained project scheduling problem with stochastic activity durations. We introduce a new class of scheduling policies for solving this problem, which make a number of a-priori sequencing decisions in a pre-processing phase while the remaining decisions are made dynamically during project execution. The pre-processing decisions entail the addition of extra precedence constraints to the scheduling instance, hereby resolving some potential resource conflicts. We obtain new competitive results for expected-makespan minimization on representative datasets, which are significantly better than those obtained by the existing algorithms when the variability in the activity durations is medium to high.     

Child negative emotionality and parenting from infancy to preschool: A meta-analytic review.

This meta-analytic review (k = 62 studies; N = 7,613 mother-child dyads) shows that effect sizes for the association between child negative emotionality and parenting were generally small and were moderated by sample and measurement characteristics. The association between more child negative emotionality and less supportive parenting was relatively strong in lower socioeconomic status families, reversed in higher socioeconomic status families, and limited to studies with relatively high percentages of participants from ethnic minorities and studies using parent report to assess negative emotionality. Higher levels of child negative emotionality were associated with more restrictive control in samples with less than 75% 1st-born children, as well as in infants and preschoolers, and in studies using parent report or composite measures to assess both negative emotionality and restrictive parenting. Finally, more child negative emotionality was associated with less inductive control. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sexual behavior increases dopamine transmission in the nucleus accumbens and striatum of male rats: Comparison with novelty and locomotion.

Extracellular concentrations of dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were examined concurrently, using in vivo microdialysis, in the nucleus accumbens and dorsal striatum of sexually active male rats during tests of locomotor activity, exposure to a novel chamber, exposure to sex odors, the presentation of a sexually receptive female, and copulation. DA increased significantly in the nucleus accumbens when the males were presented with a sexually receptive female behind a screen and increased further during copulation. Although DA also increased significantly in the dorsal striatum during copulation, the magnitude of the effect was significantly lower than that observed in the nucleus accumbens. In contrast, forced locomotion on a rotating drum, exposure to a novel chamber, and exposure to sex odors did not increase DA significantly in either region. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

RLS-based initialization for per-tone equalizers in DMT receivers

Per-tone equalization has recently been proposed as an alternative receiver structure for discrete multitone-based systems improving upon the well-known structure based on time-domain equalization. Fast initialization of all the equalizer coefficients has been identified as an open problem. In this letter, a recursive initialization scheme based on recursive least squares with inverse updating is presented for the per-tone equalizers. Simulation results show convergence with an acceptably small number of training symbols. Complexity calculations are made for per-tone equalization and for the case where tones are grouped. It is demonstrated with an example that in the latter case, initialization complexity becomes sufficiently low and comparable to complexity during data transmission.     

Adoption and Use of Interorganizational ICT in a Construction Project

The objective of this research is to explain why actors are not using interorganizational information and communication technology (ICT) in construction projects in the intended way, by determining the mechanisms that influence the way actors use this ICT over time during a construction project. This explorative research results in a theoretical model that contains four key categories that explains the way actors use ICT in construction projects: (1) personal motivation; (2) external motivation; (3) knowledge and skills; and (4) acting opportunities. The model is compared with three existing influential models about the adoption and use of ICT: the unified theory of acceptance and use of technology, the theory of planned behavior, and the technology acceptance model. In these models missing elements are found. In addition, it is found that fundamental characteristics of construction projects, such as the fragmented and temporarily nature of construction projects, and the different working practices, resources, and objectives of the organizations involved cause most of the barriers to the intended use of interorganizational ICT.     

Evaluative conditioning in humans: A meta-analysis.

This article presents a meta-analysis of research on evaluative conditioning (EC), defined as a change in the liking of a stimulus (conditioned stimulus; CS) that results from pairing that stimulus with other positive or negative stimuli (unconditioned stimulus; US). Across a total of 214 studies included in the main sample, the mean EC effect was d = .52, with a 95% confidence interval of .466–.582. As estimated from a random-effects model, about 70% of the variance in effect sizes were attributable to true systematic variation rather than sampling error. Moderator analyses were conducted to partially explain this variation, both as a function of concrete aspects of the procedural implementation and as a function of the abstract aspects of the relation between CS and US. Among a range of other findings, EC effects were stronger for high than for low contingency awareness, for supraliminal than for subliminal US presentation, for postacquisition than for postextinction effects, and for self-report than for implicit measures. These findings are discussed with regard to the procedural boundary conditions of EC and theoretical accounts about the mental processes underlying EC. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Clinical evaluation of respiratory motion compensation for anatomical roadmap guided cardiac electrophysiology procedures

X-ray fluoroscopically guided cardiac electrophysiological procedures are routinely carried out for diagnosis and treatment of cardiac arrhythmias. X-ray images have poor soft tissue contrast and, for this reason, overlay of static 3-D roadmaps derived from preprocedural volumetric data can be used to add anatomical information. However, the registration between the 3-D roadmap and the 2-D X-ray image can be compromised by patient respiratory motion. Three methods were designed and evaluated to correct for respiratory motion using features in the 2-D X-ray images. The first method is based on tracking either the diaphragm or the heart border using the image intensity in a region of interest. The second method detects the tracheal bifurcation using the generalized Hough transform and a 3-D model derived from 3-D preoperative volumetric data. The third method is based on tracking the coronary sinus (CS) catheter. This method uses blob detection to find all possible catheter electrodes in the X-ray image. A cost function is applied to select one CS catheter from all catheter-like objects. All three methods were applied to X-ray images from 18 patients undergoing radiofrequency ablation for the treatment of atrial fibrillation. The 2-D target registration errors (TRE) at the pulmonary veins were calculated to validate the methods. A TRE of 1.6 mm ± 0.8 mm was achieved for the diaphragm tracking; 1.7 mm ± 0.9 mm for heart border tracking, 1.9 mm ± 1.0 mm for trachea tracking, and 1.8 mm ± 0.9 mm for CS catheter tracking. We present a comprehensive comparison between the techniques in terms of robustness, as computed by tracking errors, and accuracy, as computed by TRE using two independent approaches.     

R&D project scheduling when activities may fail

An R&D project typically consists of several stages. Due to technological risks, the project may have to be terminated before completion, each stage having a specific likelihood of success. In the project planning and scheduling literature, this technological uncertainty has typically been ignored and project plans are developed only for scenarios in which the project succeeds. In this paper we examine how to schedule projects in order to maximize their expected net present value when the project activities have a probability of failure and when an activity's failure leads to overall project termination. We formulate the problem, show that it is NP-hard, develop a branch-and-bound algorithm that allows us to obtain optimal solutions and provide extensive computational results. In the process, we establish a complexity result for an open problem in single-machine scheduling, namely for the discounted weighted-completion-time objective with general precedence constraints.