Occurrence,prevention and remediation of toxigenic fungi and mycotoxins in silage: a review

Ruminants are considered to be less sensitive towards mycotoxins than monogastric animals because rumen microbiota have mycotoxin‐detoxifying capacities. Therefore the effect of mycotoxins towards ruminants has been studied to a lesser extent compared with monogastric animals. Worldwide, a high proportion of the ruminant diet consists of silages made of forage crops (i.e. all parts of the crop above the stubble are harvested). In practice, silages are often contaminated with multiple mycotoxins. Exposure to a cocktail of mycotoxins can hamper animal production and have severe health consequences. In this article the different aspects associated with mycotoxin contamination of silage are reviewed ‘from seed to feed’. An overview is given on the occurrence of toxigenic fungal species and their concomitant mycotoxins in forage crops before and after ensiling. The mycotoxin load of visually non‐mouldy samples and mouldy hot spots within the same silo is also compared. Subsequently, this review delves into different problem‐solving strategies. A logical first step is prevention of mould growth and mycotoxin production in the field, during harvest and during ensiling. If prevention should fail, several remediation strategies are available. These are listed, mainly focusing on the possibilities of microbial degradation of mycotoxins in vivo in silage. © 2015 Society of Chemical Industry     

Biofuel developments in Sweden and the Netherlands: Protection and socio-technical change in a long-term perspective

This paper reviews long-term development of biofuels in Sweden and the Netherlands. In particular this paper explores the social dynamics of ‘niche protection’. The Swedish and Dutch cases are analyzed by means of the Strategic Niche Management (SNM) perspective extended with insights from political science. Our main argument is that the development of biofuels and the way this development is protected relies on a variety of actor strategies and (local and global) discourses. This case therefore suggests that policy making for biofuels is a complex and non-linear process that can only partly be managed by policy actors.     

Reducing drying energy and costs by process alterations at aggregate stockpiles

In the field of bulk solids, handling knowledge on moisture behaviour in aggregate stockpiles can be useful for process optimisation in terms of energy consumption. In the asphalt industry, an increase in moisture content leads to a significant increase in energy consumption. To determine the characteristics of moisture behaviour, correlations are investigated between theory on soil–water movements and moisture in aggregates. With column drainage experiments with porous bottom, similarities between theory and practice are found. This allows the use of theoretical hydrologic models to determine and predict the moisture behaviour in drained piles. The effect of process alterations within the system of piles on energy consumption was investigated, and a significant reduction of energy consumption was found.     

Automated conceptual model clustering: a relator-centric approach

Software and Systems Modeling - In recent years, there has been a growing interest in the use of reference conceptual models to capture information about complex and sensitive business domains...     

On-line monitoring of fatigue cracks using ultrasonic surface waves

During the last decade many techniques were developed to detect fatigue cracks, and estimate their location and size. Unfortunately, most of the currently available nondestructive testing methods are off-line: the operational (or fatigue) loading and the inspection are considered as two distinct stages. Mostly, the loading should be released before inspection can take place, and sometimes the device under test even has to be disassembled. In this article, an experimental methodology based on ultrasonic surface waves will be developed to continuously inspect a structure during its operation. The proposed method uses spectral information of transmitted surface waves at several working points of the operational load. Simple statistical indicators of the transmitted wave energy during loading are introduced in order to be able to monitor the structural health on-line. As a validation experiment, a propagating fatigue crack in a sinusoidally loaded beam will be considered. In addition, a comparison with an off-line method is made, showing that the on-line method is also much more sensitive.     

Intraindividual variability in infant behavior.

Longitudinal observational data of infant crying, fretting/fussing, and smiling and the time spent in physical contact with the mother were used in a study on behavioral variability. The infants were followed weekly for a 15-month period. Evidence was found of an important intraindividual variability in the studied behaviors, specifically between the ages of 0 and 5 months, 5 and 10 months, but not between 10 and 15 months. Results are discussed and analyzed in the light of earlier literature. The possible functions and the factors underlying variability in development as well as its methodological implications are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A comparison of overall and sub-area journal influence: The case of the accounting literature

In most scientific disciplines, a number of divergent and often highly specialized research areas are examined, which is reflected in substantial differences among journal scopes. Using the accounting literature as an example, we argue that this diversity in scopes should be considered when assessing journal influence. Concretely, we examine a citation-based structural influence measure for a sample of 41 accounting journals. Next, we identify sub-areas in the accounting literature and we explore journal influence in these sub-areas. Our results clearly demonstrate the importance of distinguishing between overall and sub-area influence. In addition, we show that sub-areas should be identified using a fuzzy clustering procedure.     

Connect & Drive: design and evaluation of cooperative adaptive cruise control for congestion reduction

Road throughput can be increased by driving at small inter-vehicle time gaps. The amplification of velocity disturbances in upstream direction, however, poses limitations to the minimum feasible time gap. This effect is covered by the notion of string stability. String-stable behavior is thus considered an essential requirement for the design of automatic distance control systems, which are needed to allow for safe driving at time gaps well below 1 s. Using wireless inter-vehicle communications to provide real-time information of the preceding vehicle, in addition to the information obtained by common Adaptive Cruise Control (ACC) sensors, appears to significantly decrease the feasible time gap, which is shown by practical experiments with a test fleet consisting of six passenger vehicles. The large-scale deployment of this system, known as Cooperative ACC (CACC), however, poses challenges with respect to the reliability of the wireless communication system. A solution for this scalability problem can be found in decreasing the transmission power and/or beaconing rate, or adapting the communications protocol. Although the main CACC objective is to increase road throughput, the first commercial application of CACC is foreseen to be in truck platooning, since short distance following is expected to yield significant fuel savings in this case.

     

Immune and Anticancer Responses Elicited by Fully Synthetic Aberrantly Glycosylated MUC1 Tripartite Vaccines Modified by a TLR2 or TLR9 Agonist

The mucin MUC1 is overexpressed and aberrantly glycosylated by many epithelial cancer cells manifested by truncated O‐linked saccharides. Although tumor‐associated MUC1 has generated considerable attention because of its potential for the development of a therapeutic cancer vaccine, it has been difficult to design constructs that consistently induce cytotoxic T‐lymphocytes (CTLs) and ADCC‐mediating antibodies specific for the tumor form of MUC1. We have designed, chemically synthesized, and immunologically examined vaccine candidates each composed of a glycopeptide derived from MUC1, a promiscuous T_helper peptide, and a TLR2 (Pam₃CysSK₄) or TLR9 (CpG‐ODN 1826) agonist. It was found that the Pam₃CysSK₄‐containing compound elicits more potent antigenic and cellular immune responses, resulting in a therapeutic effect in a mouse model of mammary cancer. It is thus shown, for the first time, that the nature of an inbuilt adjuvant of a tripartite vaccine can significantly impact the quality of immune responses elicited against a tumor‐associated glycopeptide. The unique adjuvant properties of Pam₃CysSK₄, which can reduce the suppressive function of regulatory T cells and enhance the cytotoxicity of tumor‐specific CTLs, are likely responsible for the superior properties of the vaccine candidate 1 .