The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms

Patients with inflammatory bowel disease (IBD) have increased incidence of colorectal cancer (CRC). IBD-associated cancer follows a well-characterized sequence of intestinal epithelial changes, in which genetic mutations and molecular aberrations play a key role. IBD-associated cancer develops against a background of chronic inflammation and pro-inflammatory immune cells, and their products contribute to cancer development and progression. In recent years, the effect of the immunosuppressive microenvironment in cancer development and progression has gained more attention, mainly because of the unprecedented anti-tumor effects of immune checkpoint inhibitors in selected groups of patients. Even though IBD-associated cancer develops in the background of chronic inflammation which is associated with activation of endogenous anti-inflammatory or suppressive mechanisms, the potential role of an immunosuppressive microenvironment in these cancers is largely unknown. In this review, we outline the role of the immune system in promoting cancer development in chronic inflammatory diseases such as IBD, with a specific focus on the anti-inflammatory mechanisms and suppressive immune cells that may play a role in IBD-associated tumorigenesis.     

The 802.11n MIMO-OFDM Standard for Wireless LAN and Beyond

An overview is given of the new IEEE 802.11n standard. This is the first wireless LAN standard based on MIMO-OFDM, a technique pioneered by Airgo Networks to give a significant performance increase in both range and rate relative to conventional wireless LAN. Performance results show that net user throughputs over 100 Mbps are achievable, which is about four times larger than the maximum achievable throughput using IEEE 802.11a/g. For the same throughput, MIMO-OFDM achieves a range that is about 3 times larger than non-MIMO systems. This significant improvement in range-rate performance makes MIMO-OFDM the ideal solution not only for wireless LAN, but also for home entertainment networks and 4G networks. Richard van Nee received the M.Sc. degree in Electrical Engineering from Twente University in Enschede, the Netherlands, in 1990. In May 1995, he received the PhD degree from Delft University of Technology. From 1995 to 2000, he worked for Lucent Technologies Bell Labs on wireless LAN transmission techniques. He was one of the original proposers of the CCK and OFDM modulation techniques which were adopted by the IEEE 802.11b and IEEE802.11a wireless LAN standards. In 2001, he cofounded Airgo Networks that developed the first MIMO-OFDM modem for wireless LAN and which techniques form the basis of the IEEE 802.11n standard. Together with Ramjee Prasad, he wrote a book on OFDM, entitled ‘OFDM for Mobile Multimedia Communications.’ In 2002 he received the Dutch Veder award for his contributions to standardization of wireless communications.     

A Compact Model for Valence-Band Electron Tunneling Current in Partially Depleted SOI MOSFETs

The valence-band electron (EVB) tunneling current in partially depleted silicon-on-insulator (SOI) MOSFETs increases as the gate oxide gets thinner and affects the dynamic behavior of devices and circuits. We present an engineering model of EVB tunneling current based on the surface-potential formulation. The new model is implemented in a SOI MOSFET compact model and is used to study the impact of EVB tunneling on circuit performance. Simulations of stacked logic gates show that the EVB tunneling current not only boosts circuit switching speed but also mitigates the history dependence of propagation delays     

On the existence of periodic behaviour of switched linear systems

A heuristic algorithm is suggested for approximating the departure process from a G/M/1 queueing system with generally distributed interarrival times, a single markovian server, an infinite capacity, and the first-come first-served queueing discipline, in the steady state. The tandem behaviour of the system is then approximated in the steady state. Finally, the approximation results are compared against both a simulation study and the approximation results of Kuehn (1979) and Whitt (1983 a, b).     

Annotating mobile phone location data with activity purposes using machine learning algorithms

Individual human travel patterns captured by mobile phone data have been quantitatively characterized by mathematical models, but the underlying activities which initiate the movement are still in a less-explored stage. As a result of the nature of how activity and related travel decisions are made in daily life, human activity-travel behavior exhibits a high degree of spatial and temporal regularities as well as sequential ordering. In this study, we investigate to what extent the behavioral routines could reveal the activities being performed at mobile phone call locations that are captured when users initiate or receive a voice call or message.Our exploration consists of four steps. First, we define a set of comprehensive temporal variables characterizing each call location. Feature selection techniques are then applied to choose the most effective variables in the second step. Next, a set of state-of-the-art machine learning algorithms including Support Vector Machines, Logistic Regression, Decision Trees and Random Forests are employed to build classification models. Alongside, an ensemble of the results of the above models is also tested. Finally, the inference performance is further enhanced by a post-processing algorithm.Using data collected from natural mobile phone communication patterns of 80 users over a period of more than one year, we evaluated our approach via a set of extensive experiments. Based on the ensemble of the models, we achieved prediction accuracy of 69.7%. Furthermore, using the post processing algorithm, the performance obtained a 7.6% improvement. The experiment results demonstrate the potential to annotate mobile phone locations based on the integration of data mining techniques with the characteristics of underlying activity-travel behavior, contributing towards the semantic comprehension and further application of the massive data.     

The oxidation of Fe(II) with Cu(II) in acidic sulfate solutions with air at elevated pressures

The oxidation of ferrous ions in acidic sulfate solutions in the presence of cupric ions at elevated air pressures was investigated in a high-intensity gas–liquid contactor. The study was required for the design of the regeneration steps of the novel Vitrisol^® desulphurization process. The effects of the Fe²⁺ concentration, Cu²⁺ concentration, Fe³⁺ concentration, initial H₂SO₄ concentration, and partial oxygen pressure on the reaction rate were determined at three different temperatures, i.e., T?=?50?°C, 70?°C, and 90?°C. Most of the experiments were determined to be affected by the mass transfer of oxygen, and therefore true intrinsic kinetics could not be fully determined. An increase in Fe²⁺ and Cu²⁺ concentrations, as well as the partial pressure of oxygen and temperature, increased the Fe²⁺ oxidation rate. H₂SO₄ did not influence the Fe²⁺ oxidation rate. An increase in Fe³⁺ concentration decreased the Fe²⁺ oxidation rate. Although determined from experiments partially affected by mass transfer, a first order of reaction in Fe²⁺ was observed, fractional orders in both Cu²⁺ and O₂ were measured, a zero order in H₂SO₄ was determined, and a negative, fractional order in Fe³⁺ was obtained. The activation energy was estimated to be 31.3?kJ/mol.     

Identification of Phenylpyrazolone Dimers as a New Class of Anti-Trypanosoma cruzi Agents

Chagas disease is becoming a worldwide problem; it is currently estimated that over six million people are infected. The two drugs in current use, benznidazole and nifurtimox, require long treatment regimens, show limited efficacy in the chronic phase of infection, and are known to cause adverse effects. Phenotypic screening of an in-house library led to the identification of 2,2′-methylenebis(5-(4-bromophenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one), a phenyldihydropyrazolone dimer, which shows an in vitro pIC₅₀ value of 5.4 against Trypanosoma cruzi. Initial optimization was done by varying substituents of the phenyl ring, after which attempts were made to replace the phenyl ring. Finally, the linker between the dimer units was varied, ultimately leading to 2,2′-methylenebis(5-(3-bromo-4-methoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (NPD-0228) as the most potent analogue. NPD-0228 has an in vitro pIC₅₀ value of 6.4 against intracellular amastigotes of T. cruzi and no apparent toxicity against the human MRC-5 cell line and murine cardiac cells.     

Chloride binding isotherm from migration and diffusion tests

Chloride binding is often described by chloride binding isotherm, which is closely related to the service life of concrete structures in chloride environments. Many methods have been proposed to determine chloride binding isotherm. Compared to other methods, chloride binding isotherms obtained directly from nonsteady-state diffusion tests seem closer to the reality. We studied the chloride binding isotherm from both nonsteady-state electrical-accelerated migration and diffusion tests at different temperatures. Twelve concrete mixes with different supplementary cementing materials and water-to-binder ratios of 0.35, 0.48 and 0.6 were cast for study. The specimens after diffusion (or migration) tests were sliced layer by layer, and acid-soluble and free chloride contents of each layer were measured. A chloride binding isotherm was obtained from one specimen. Experimental results indicated that electrical voltage had a slight effect on the chloride binding isotherm of concrete. Temperature had a positive effect on chloride binding. The higher the water-to-binder ratio was, the higher the chloride binding was.     

Incorporating fuzziness in the classical decision table formalism

In this article different aspects of the decision table formalism are discussed. First, crisp decision tables are defined and their construction is described. Next, fuzzy extensions are made to crisp decision tables in order to deal with imprecision and uncertainty. As a result, with crisp decision tables as special cases, a form of fuzzy decision tables is defined which include fuzziness in the conditions as well as in the actions. Consequently, the concept of completeness is introduced in the context of fuzzy decision tables. Furthermore, fuzzy consultation of decision tables is discussed, which allows decision making with fuzziness based on the matching between fuzzy conditions and the concept of fuzzy logical implication. © 1996 John Wiley & Sons, Inc.