Hyperprolactinemia in end‐stage renal disease and effects of frequent hemodialysis

Introduction: End‐stage renal disease is associated with elevations in circulating prolactin concentrations, but the association of prolactin concentrations with intermediate health outcomes and the effects of hemodialysis frequency on changes in serum prolactin have not been examined. Methods: The FHN Daily and Nocturnal Dialysis Trials compared the effects of conventional thrice weekly hemodialysis with in‐center daily hemodialysis (6 days/week) and nocturnal home hemodialysis (6 nights/week) over 12 months and obtained measures of health‐related quality of life, self‐reported physical function, mental health and cognition. Serum prolactin concentrations were measured at baseline and 12‐month follow‐up in 70% of the FHN Trial cohort to examine the associations among serum prolactin concentrations and physical, mental and cognitive function and the effects of hemodialysis frequency on serum prolactin. Findings: Among 177 Daily Trial and 60 Nocturnal Trial participants with baseline serum prolactin measurements, the median serum prolactin concentration was 65 ng/mL (25th–75th percentile 48–195 ng/mL) and 81% had serum prolactin concentrations >30 ng/mL. While serum prolactin was associated with sex (higher in women), we observed no association between baseline serum prolactin and age, dialysis vintage, and baseline measures of physical, mental and cognitive function. Furthermore, there was no significant effect of hemodialysis frequency on serum prolactin in either of the two trials. Discussion: Serum prolactin concentrations were elevated in the large majority of patients with ESRD, but were not associated with several measures of health status. Circulating prolactin levels also do not appear to decrease in response to more frequent hemodialysis over a one‐year period.     

The Formation of Calcified Nanospherites during Micropetrosis Represents a Unique Mineralization Mechanism in Aged Human Bone

Osteocytes—the central regulators of bone remodeling—are enclosed in a network of microcavities (lacunae) and nanocanals (canaliculi) pervading the mineralized bone. In a hitherto obscure process related to aging and disease, local plugs in the lacuno‐canalicular network disrupt cellular communication and impede bone homeostasis. By utilizing a suite of high‐resolution imaging and physics‐based techniques, it is shown here that the local plugs develop by accumulation and fusion of calcified nanospherites in lacunae and canaliculi (micropetrosis). Two distinctive nanospherites phenotypes are found to originate from different osteocytic elements. A substantial deviation in the spherites' composition in comparison to mineralized bone further suggests a mineralization process unlike regular bone mineralization. Clearly, mineralization of osteocyte lacunae qualifies as a strong marker for degrading bone material quality in skeletal aging. The understanding of micropetrosis may guide future therapeutics toward preserving osteocyte viability to maintain mechanical competence and fracture resistance of bone in elderly individuals.     

Heavy metal removal from simulated wastewater using electrochemical technology: optimization of copper electrodeposition in a membraneless fluidized bed electrode

Heavy metal removal from industrial wastewaters has been intensively studied, since it is well known that they can cause severe problems to human health and aquatic life, even at very low concentrations. In this work, it was demonstrated that electrodeposition in fluidized bed electrode (FBE) can be efficiently employed to remove metal ions from solution, avoid contamination, and recover the metal. Copper electrodeposition from diluted solutions was efficiently performed using a membraneless FBE. The average current efficiency (ACE), average energy consumption (AEC), and space–time yield (AY) was optimized taking into account the operational and process variables. It was noted that for all response variables studied, the raise of supporting electrolyte concentration (C _s) contributed to improvements in the process. The operational conditions current (I) and bed expansion (E) determined the values of CE, Y, and EC under activated control, but the initial copper concentration (C ₀) determined how long the electrodeposition process will work under activated or mass transfer control, thus affecting the average values of CE, Y, and EC. Considering C ₀ of 500 mg L^?1, copper can be optimally recovered with ACE >60 %, AY >38 kg h^?1 m^?3, and AEC <4.0 kWh kg^?1 by applying the lowest I and the highest levels of E and C _s. It was concluded that the electrochemical technology using a membraneless FBE reactor is economically competitive and be applied for the treatment of wastewaters contaminated with copper or other metals.     

Plasmon resonant amplification of a hot electron-driven photodiode

Nano Research - We report plasmon resonant excitation of hot electrons in a photodetector based on a metal/oxide/metal (Au/Al2O3/graphene) heterostructure. In this device, hot electrons, excited...     

Heart valve involvement (Libman-Sacks endocarditis) in the antiphospholipid syndrome

The antiphospholipid syndrome (APS) is defined by the presence of anti-phospholipid antibodies (aPLs) and venous or arterial thrombosis, recurrent pregnancy loss, or thrombocytopenia. The syndrome can be either primary or secondary to an underlying condition, most commonly systemic lupus erythematosus (SLE). Echocardiographic studies have disclosed heart valve abnormalities in about a third of patients with primary APS. SLE patients with aPLs have a higher prevalence of valvular involvement than those without these antibodies. Valvular lesions associated with aPLs occur as valve masses (nonbacterial vegetations) or thickening. These two morphological alterations can be combined and are thought to reflect the same pathological process. Both can be associated with valve dysfunction, although such association is much more common with the latter alteration. The predominant functional abnormality is regurgitation; stenosis is rare. The mitral valve is mainly affected, followed by the aortic valve. Valvular involvement usually does not cause clinical valvular disease. The presence of aPLs seems to further increase the risk for thromboembolic complications, mainly cerebrovascular, posed by valve lesions. Superadded bacterial endocarditis is rare but may be difficult to distinguish from pseudoinfective endocarditis. The current therapeutic guidelines are those for APS in general. Secondary antithrombotic prevention with long-term, high-intensity oral anticoagulation is advised. The efficacy of aspirin, either alone or in combination, is yet to be assessed. Corticosteroids are not beneficial and may even facilitate valve damage. Immunosuppressive agents should only be used for the treatment of an underlying condition. Current data suggest a role for aPLs in the pathogenesis of valvular lesions. aPLs may promote the formation of valve thrombi. These antibodies may also act by another mechanism, as indicated by the finding of subendothelial deposits of immunoglobulins, including anticardiolipin antibodies, and of colocalized complement components in deformed valves from patients with APS.     

A scalable approach to mapping annual land cover at 250 m using MODIS time series data: A case study in the Dry Chaco ecoregion of South America

Land use and land cover (LULC) maps from remote sensing are vital for monitoring, understanding and predicting the effects of complex human-nature interactions that span local, regional and global scales. We present a method to map annual LULC at a regional spatial scale with source data and processing techniques that permit scaling to broader spatial and temporal scales, while maintaining a consistent classification scheme and accuracy. Using the Dry Chaco ecoregion in Argentina, Bolivia and Paraguay as a test site, we derived a suite of predictor variables from 2001 to 2007 from the MODIS 250 m vegetation index product (MOD13Q1). These variables included: annual statistics of red, near infrared, and enhanced vegetation index (EVI), phenological metrics derived from EVI time series data, and slope and elevation. For reference data, we visually interpreted percent cover of eight classes at locations with high-resolution QuickBird imagery in Google Earth. An adjustable majority cover threshold was used to assign samples to a dominant class. When compared to field data, we found this imagery to have georeferencing error < 5% the length of a MODIS pixel, while most class interpretation error was related to confusion between agriculture and herbaceous vegetation. We used the Random Forests classifier to identify the best sets of predictor variables and percent cover thresholds for discriminating our LULC classes. The best variable set included all predictor variables and a cover threshold of 80%. This optimal Random Forests was used to map LULC for each year between 2001 and 2007, followed by a per-pixel, 3-year temporal filter to remove disallowed LULC transitions. Our sequence of maps had an overall accuracy of 79.3%, producer accuracy from 51.4% (plantation) to 95.8% (woody vegetation), and user accuracy from 58.9% (herbaceous vegetation) to 100.0% (water). We attributed map class confusion to limited spectral information, sub-pixel spectral mixing, georeferencing error and human error in interpreting reference samples. We used our maps to assess woody vegetation change in the Dry Chaco from 2002 to 2006, which was characterized by rapid deforestation related to soybean and planted pasture expansion. This method can be easily applied to other regions or continents to produce spatially and temporally consistent information on annual LULC.     

Design and implementation of high-speed buffered crossbars with efficient load balancing for multi-core SoCs

A large increase of the number of devices integrated in a single chip in conjunction with the significant demands of modern applications for performance has led the designers to a system development methodology based on integrating multiple pre-verified intellectual property cores. Yet, design productivity requirements push designers to focus on key micro-architectural solutions to manage more efficiently the scaling of multi-core SoCs as well as to increase the degree of design automation, particularly as rapid prototyping using reconfigurable computing is becoming mainstream. In this paper we present a novel interconnect architecture based on optimized components to efficiently manage SoCs that follow either a multi-core based approach or are built to support SIMD-style applications that can exploit the processing power of a pool of hardware resources; first we analyze the design of a crossbar featuring shared-memory combined input-crosspoint buffering as a solution for efficient implementation of on-chip interconnection; second we describe the design of a load-balancer featuring configurable proportional allocation of on-chip resources and in-order delivery as a solution for efficient scheduling and execution of processing tasks. The main focus of the paper is to describe and evaluate the mechanisms designed to distribute and manage data transfers so as to implement an efficient interconnection of the integrated cores and control access to available (either on-chip or off-chip) resources for the implementation of a number of embedded systems and applications. Each of these challenges is handled by the proposed architecture in an efficient way in terms of performance, cost in silicon and flexibility.     

Quantile map: Simultaneous visualization of patterns in many distributions with application to tandem mass spectrometry

High-throughput experiments have become more and more prevalent in biomedical research. The resulting high-dimensional data have brought new challenges. Effective data reduction, summarization and visualization are important keys to initial exploration in data mining. In this paper, we introduce a visualization tool, namely a quantile map, to present information contained in a probabilistic distribution. We demonstrate its use as an effective visual analysis tool through the application of a tandem mass spectrometry data set. Information of quantiles of a distribution is presented in gradient colors by concentric doughnuts. The width of the doughnuts is proportional to the Fisher information of the distribution to present unbiased visualization effect. A parametric empirical Bayes (PEB) approach is shown to improve the simple maximum likelihood estimate (MLE) approach when estimating the Fisher information. In the motivating example from tandem mass spectrometry data, multiple probabilistic distributions are to be displayed in two-dimensional grids. A hierarchical clustering to reorder rows and columns and a gradient color selection from a Hue-Chroma-Luminance model, similar to that commonly applied in heatmaps of microarray analysis, are adopted to improve the visualization. Both simulations and the motivating example show superior performance of the quantile map in summarization and visualization of such high-throughput data sets.     

Optimization of a multi-Constant Work-in-Process semiconductor assembly and test factory based on performance evaluation

This paper considers a semiconductor assembly and test factory which is a three-segment-Constant Work-in-Process (CONWIP) system with overlapping machines. In the system, three types of carts circulate for meeting the physical requirements. The optimization problem in setting the suitable total Work-in-Process (WIP) level and the distribution in the three loops from the view of the trade-off between the throughput and the WIP level for the system is addressed. In the proposed model, the system is firstly modeled as a three-loop closed queue network and we propose an approximate method to evaluate the performance. The accuracy of the evaluation method was illustrated by numerical experiments, indicating that the method is fairly precise. Secondly, a Genetic Algorithm is designed to obtain near optimal results based on the performance evaluation. The semiconductor assembly and test system case as well as the application procedure were carried out in detail.