全文获取类型
收费全文 | 739篇 |
免费 | 47篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 17篇 |
化学工业 | 200篇 |
金属工艺 | 5篇 |
机械仪表 | 20篇 |
建筑科学 | 31篇 |
能源动力 | 28篇 |
轻工业 | 99篇 |
水利工程 | 6篇 |
石油天然气 | 1篇 |
无线电 | 48篇 |
一般工业技术 | 117篇 |
冶金工业 | 69篇 |
原子能技术 | 4篇 |
自动化技术 | 142篇 |
出版年
2024年 | 2篇 |
2023年 | 13篇 |
2022年 | 35篇 |
2021年 | 47篇 |
2020年 | 25篇 |
2019年 | 24篇 |
2018年 | 33篇 |
2017年 | 28篇 |
2016年 | 30篇 |
2015年 | 22篇 |
2014年 | 33篇 |
2013年 | 52篇 |
2012年 | 28篇 |
2011年 | 40篇 |
2010年 | 37篇 |
2009年 | 45篇 |
2008年 | 23篇 |
2007年 | 31篇 |
2006年 | 28篇 |
2005年 | 14篇 |
2004年 | 12篇 |
2003年 | 12篇 |
2002年 | 5篇 |
2001年 | 6篇 |
2000年 | 9篇 |
1999年 | 12篇 |
1998年 | 30篇 |
1997年 | 14篇 |
1996年 | 13篇 |
1995年 | 5篇 |
1994年 | 7篇 |
1993年 | 6篇 |
1992年 | 2篇 |
1991年 | 5篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1987年 | 6篇 |
1986年 | 5篇 |
1985年 | 5篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1982年 | 5篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1976年 | 1篇 |
1971年 | 1篇 |
1970年 | 2篇 |
排序方式: 共有787条查询结果,搜索用时 0 毫秒
21.
Hyung Seok Kim Chris Joslin Thomas Di Giacomo Stephane Garchery Nadia Magnenat-Thalmann 《The Visual computer》2006,22(5):332-345
The goal of this research was the creation of an adaptation mechanism for the delivery of three-dimensional content. The adaptation of content, for various network and terminal capabilities – as well as for different user preferences, is a key feature that needs to be investigated. Current state-of-the art research of the adaptation shows promising results for specific tasks and limited types of content, but is still not well-suited for massive heterogeneous environments. In this research, we present a method for transmitting adapted three-dimensional content to multiple target devices. This paper presents some theoretical and practical methods for adapting three-dimensional content, which includes shapes and animation. We also discuss practical details of the integration of our methods into MPEG-21 and MPEG-4 architectures. 相似文献
22.
Alessia Mauri Alessandra Duse Giacomo Palm Roberto Previtali Stefania Maria Bova Sara Olivotto Sara Benedetti Francesca Coscia Pierangelo Veggiotti Cristina Cereda 《International journal of molecular sciences》2022,23(21)
GLUT1 deficiency syndrome (GLUT1DS1; OMIM #606777) is a rare genetic metabolic disease, characterized by infantile-onset epileptic encephalopathy, global developmental delay, progressive microcephaly, and movement disorders (e.g., spasticity and dystonia). It is caused by heterozygous mutations in the SLC2A1 gene, which encodes the GLUT1 protein, a glucose transporter across the blood-brain barrier (BBB). Most commonly, these variants arise de novo resulting in sporadic cases, although several familial cases with AD inheritance pattern have been described. Twenty-seven Italian pediatric patients, clinically suspect of GLUT1DS from both sporadic and familial cases, have been enrolled. We detected by trios sequencing analysis 25 different variants causing GLUT1DS. Of these, 40% of the identified variants (10 out of 25) had never been reported before, including missense, frameshift, and splice site variants. Their structural mapping on the X-ray structure of GLUT1 strongly suggested the potential pathogenic effects of these novel disease-related mutations, broadening the genotypic spectrum heterogeneity found in the SLC2A1 gene. Moreover, 24% is located in a vulnerable region of the GLUT1 protein that involves transmembrane 4 and 5 helices encoded by exon 4, confirming a mutational hotspot in the SLC2A1 gene. Lastly, we investigated possible correlations between mutation type and clinical and biochemical data observed in our GLUT1DS cohort, revealing that splice site and frameshift variants are related to a more severe phenotype and low CSF parameters. 相似文献
23.
Melania Ruggiero Rosa Calvello Chiara Porro Giovanni Messina Antonia Cianciulli Maria Antonietta Panaro 《International journal of molecular sciences》2022,23(21)
In recent years, there has been considerable research showing that coffee consumption seems to be beneficial to human health, as it contains a mixture of different bioactive compounds such as chlorogenic acids, caffeic acid, alkaloids, diterpenes and polyphenols. Neurodegenerative diseases (NDs) are debilitating, and non-curable diseases associated with impaired central, peripheral and muscle nervous systems. Several studies demonstrate that neuroinflammation mediated by glial cells—such as microglia and astrocytes—is a critical factor contributing to neurodegeneration that causes the dysfunction of brain homeostasis, resulting in a progressive loss of structure, function, and number of neuronal cells. This happens over time and leads to brain damage and physical impairment. The most known chronic NDs are represented by Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). According to epidemiological studies, regular coffee consumption is associated with a lower risk of neurodegenerative diseases. In this review, we summarize the latest research about the potential effects of caffeine in neurodegenerative disorders prevention and discuss the role of controlled caffeine delivery systems in maintaining high plasma caffeine concentrations for an extended time. 相似文献
24.
Amelia Cataldi Rosa Amoroso Viviana di Giacomo Susi Zara Cristina Maccallini Marialucia Gallorini 《International journal of molecular sciences》2022,23(23)
Nitric oxide (NO) is a key messenger in physiological and pathological processes in mammals. An excessive NO production is associated with pathological conditions underlying the inflammation response as a trigger. Among others, dental pulp inflammation results from the invasion of dentin by pathogenic bacteria. Vital functions of pulp mesenchymal stem cells (DPSCs, dental pulp stem cells), such as mineralization, might be affected by the inducible NOS (iNOS) upregulation. In this context, the iNOS selective inhibition can be considered an innovative therapeutic strategy to counteract inflammation and to promote the regeneration of the dentin-pulp complex. The present work aims at evaluating two acetamidines structurally related to the selective iNOS inhibitor 1400W, namely CM544 and FAB1020, in a model of LPS-stimulated primary DPSCs. Our data reveal that CM544 and even more FAB1020 are promising anti-inflammatory compounds, decreasing IL-6 secretion by enhancing CD73 expression-levels, a protein involved in innate immunity processes and thus confirming an immunomodulatory role of DPSCs. In parallel, cell mineralization potential is retained in the presence of compounds as well as VEGF secretion, and thus their angiogenetic potential. Data presented lay the ground for further investigation on the anti-inflammatory potential of acetamidines selectively targeting iNOS in a clinical context. 相似文献
25.
Pieter Geiregat Carmelita Rodá Ivo Tanghe Shalini Singh Alessio Di Giacomo Delphine Lebrun Gianluca Grimaldi Jorick Maes Dries Van Thourhout Iwan Moreels Arjan J.Houtepen Zeger Hens 《光:科学与应用(英文版)》2021,10(6):1122-1132
2D materials are considered for applications that require strong light-matter interaction because of the apparently giant oscillator strength of the exciton tra... 相似文献
26.
Arianna Manini Antonia Ratti Alberto Brusati Alessio Maranzano Isabella Fogh Silvia Peverelli Stefano Messina Davide Gentilini Federico Verde Barbara Poletti Claudia Morelli Vincenzo Silani Nicola Ticozzi 《International journal of molecular sciences》2022,23(16)
The transmembrane protein 106B (TMEM106B) gene is a susceptibility factor and disease modifier of frontotemporal dementia, but few studies have investigated its role in amyotrophic lateral sclerosis. The aim of this work was to assess the impact of the TMEM106B rs1990622 (A–major risk allele; G–minor allele) on phenotypic variability of 865 patients with amyotrophic lateral sclerosis. Demographic and clinical features were compared according to genotypes by additive, dominant, and recessive genetic models. Bulbar onset was overrepresented among carriers of the AA risk genotype, together with enhanced upper motor neuron involvement and poorer functional status in patients harboring at least one major risk allele (A). In a subset of 195 patients, we found that the homozygotes for the minor allele (GG) showed lower scores at the Edinburgh Cognitive and Behavioral Amyotrophic Lateral Sclerosis Screen, indicating a more severe cognitive impairment, mainly involving the amyotrophic lateral sclerosis-specific cognitive functions and memory. Moreover, lower motor neuron burden predominated among patients with at least one minor allele (G). Overall, we found that TMEM106B is a disease modifier of amyotrophic lateral sclerosis, whose phenotypic effects encompass both sites of onset and functional status (major risk allele), motor functions (both major risk and minor alleles), and cognition (minor allele). 相似文献
27.
Giacomo Lazzarino Valentina Di Pietro Marco Rinaudo Zsuzsanna Nagy Nicholas M. Barnes Lars Bruce Stefano Signoretti Renata Mangione Miriam Wissam Saab Barbara Tavazzi Antonio Belli Giuseppe Lazzarino Angela Maria Amorini Ann Logan 《International journal of molecular sciences》2022,23(15)
In a previous study, we found that administration of ILB®, a new low molecular weight dextran sulphate, significantly improved mitochondrial functions and energy metabolism, as well as decreased oxidative/nitrosative stress, of brain tissue of rats exposed to severe traumatic brain injury (sTBI), induced by the closed-head weight-drop model of diffused TBI. Using aliquots of deproteinized brain tissue of the same animals of this former study, we here determined the concentrations of 24 amino acids of control rats, untreated sTBI rats (sacrificed at 2 and 7 days post-injury) and sTBI rats receiving a subcutaneous ILB® administration (at the dose levels of 1, 5 and 15 mg/kg b.w.) 30 min post-impact (sacrificed at 2 and 7 days post-injury). Additionally, in a different set of experiments, new groups of control rats, untreated sTBI rats and ILB®-treated rats (administered 30 min after sTBI at the dose levels of 1 or 5 mg/kg b.w.) were studied for their neurocognitive functions (anxiety, locomotor capacities, short- and long-term memory) at 7 days after the induction of sTBI. Compared to untreated sTBI animals, ILB® significantly decreased whole brain glutamate (normalizing the glutamate/glutamine ratio), glycine, serine and γ-aminobutyric acid. Furthermore, ILB® administration restored arginine metabolism (preventing nitrosative stress), levels of amino acids involved in methylation reactions (methionine, L-cystathionine, S-adenosylhomocysteine), and N-acetylaspartate homeostasis. The macroscopic evidences of the beneficial effects on brain metabolism induced by ILB® were the relevant improvement in neurocognitive functions of the group of animals treated with ILB® 5 mg/kg b.w., compared to the marked cognitive decline measured in untreated sTBI animals. These results demonstrate that ILB® administration 30 min after sTBI prevents glutamate excitotoxicity and normalizes levels of amino acids involved in crucial brain metabolic functions. The ameliorations of amino acid metabolism, mitochondrial functions and energy metabolism in ILB®-treated rats exposed to sTBI produced significant improvement in neurocognitive functions, reinforcing the concept that ILB® is a new effective therapeutic tool for the treatment of sTBI, worth being tested in the clinical setting. 相似文献
28.
29.
Jeppe Rich Carlo Giacomo PratoTove Hels Allan LyckegaardNiels Buus Kristensen 《Accident; analysis and prevention》2013
While the number of fatalities on Danish roads has decreased in the last 40 years, research has not investigated the contribution of legislation changes, enforcement measures, technological enhancements, infrastructural improvements and human factors to this reduction. In the context of a Danish car market with remarkably high registration tax that causes potential buyers to hold longer onto old cars, the relationship between technological enhancements of vehicles and severity of crashes requires particular attention. 相似文献
30.
Abstract A simple scheme for the generation of a class of maximally entangled two-mode field states is presented. Our proposal provides the possibility of manipulating the quantum coherence between the superposed states, simply varying an experimentally easily controllable parameter. The practical feasibility of the method here reported is carefully discussed. 相似文献