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41.
V De Fonzo E Bersani F Aluffi-Pentini T Castrignanò V Parisi 《Canadian Metallurgical Quarterly》1998,194(1):125-142
It is well known that in some places of the human genome one finds a variable number of tandem repeats of trinucleotides; it is now commonly acknowledged that in many cases an excessive expansion of such a number is the cause of nervous system diseases. Moreover there exist cases of genetic disorders linked with loci where a variable number of tandem repeats of sequences longer than three bases has been found. The abnormal number of these repeats in few cases has been associated with the onset of the disease. Considering the above facts, we have performed an extensive study of published sequences of genes connected with various diseases. We have examined, inside or near those genes, all possible tandem repeats. The analysis has led to the detection of a large number of repeats of both triplets and longer sequences, many of which, as far as we know, had not been pointed out before. The results of our analysis lead us to put forward the hypothesis that in more cases than those till now established, a variable number of tandem repeats of generic sequences, not only of triplets, could be associated with disease onset. Finally we suggest to allocate experimental researches for all the possible tandem repeats and their possible correlation with the neurodegenerative disorders and with other kinds of syndromes. 相似文献
42.
A centre-cracked panel of elastic-plastic material of unit thickness is loaded remotely by an uniaxial traction acting along its longitudinal axis. Making use of the Dugdale-Barenblatt model, the size of the plastic zones ahead of the crack tips can be obtained by equilibrium considerations. Connected to , a generalised elastic-plastic stress intensity factor K is defined which, as 0, approaches the ordinary elastic one. Once the critical values W
c or K
c at the onset of the unstable propagation of the crack have been specified, the residual-strength curves for plane stress state can be easily deduced. Moreover, conditions are sought for which ductile fracture, brittle fracture or plastic collapse takes place. 相似文献
43.
Franz Baader Werner Nutt 《Applicable Algebra in Engineering, Communication and Computing》1996,7(4):309-337
We study the class of theories for which solving unification problems is equivalent to solving systems of linear equations over a semiring. It encompasses important examples like the theories of Abelian monoids, idempotent Abelian monoids, and Abelian groups. This class has been introduced by the authors independently of each other as commutative theories (Baader) and monoidal theories (Nutt).We show that commutative theories and monoidal theories indeed define the same class (modulo a translation of the signature), and we prove that it is undecidable whether a given theory belongs to it. In the remainder of the paper we investigate combinations of commutative/monoidal theories with other theories. We show that finitary commutative/monoidal theories always satisfy the requirements for applying general methods developed for the combination of unification algorithms for disjoint equational theories.Then we study the adjunction of monoids of homomorphisms to commutative/monoidal theories. This is a special case of a non-disjoint combination, which has an algebraic counterpart in the corresponding semiring. By studying equations over this semiring, we identify a large subclass of commutative/monoidal theories that are of unification type zero. We also show with methods from linear algebra that unitary and finitary commutative/monoidal theories do not change their unification type when they are augmented by a finite monoid of homomor-phisms, and how algorithms for the extended theory can be obtained from algorithms for the basic theory. 相似文献
44.
Samuel Rota Bulò Marcello Pelillo Immanuel M. Bomze 《Computer Vision and Image Understanding》2011,115(7):984-995
Quadratic optimization lies at the very heart of many structural pattern recognition and computer vision problems, such as graph matching, object recognition, image segmentation, etc., and it is therefore of crucial importance to devise algorithmic solutions that are both efficient and effective. As it turns out, a large class of quadratic optimization problems can be formulated in terms of so-called “standard quadratic programs” (StQPs), which ask for finding the extrema of a quadratic polynomial over the standard simplex. Computationally, the standard approach for attacking this class of problems is to use replicator dynamics, a well-known family of algorithms from evolutionary game theory inspired by Darwinian selection processes. Despite their effectiveness in finding good solutions in a variety of applications, however, replicator dynamics suffer from being computationally expensive, as they require a number of operations per step which grows quadratically with the dimensionality of the problem being solved. In order to avoid this drawback, in this paper we propose a new population game dynamics (InImDyn) which is motivated by the analogy with infection and immunization processes within a population of “players.” We prove that the evolution of our dynamics is governed by a quadratic Lyapunov function, representing the average population payoff, which strictly increases along non-constant trajectories and that local solutions of StQPs are asymptotically stable (i.e., attractive) points. Each step of InImDyn is shown to have a linear time/space complexity, thereby allowing us to use it as a more efficient alternative to standard approaches for solving StQPs and related optimization problems. Indeed, we demonstrate experimentally that InImDyn is orders of magnitude faster than, and as accurate as, replicator dynamics on various applications ranging from tree matching to image registration, matching and segmentation. 相似文献
45.
A Wireless Mesh Network (WMN) is composed of multiple Access Points (APs) that are connected together using the radio channel and by a limited number of gateway APs connected to the Internet. In this paper, we address the problem of gateway placement that consists of minimizing the number of gateways while satisfying system performance requirements. Along with the placement problem, the formulation includes joint routing and scheduling to account for the problem of interference and to enable spacial reuse. The problem, which we coined GPSRP (Gateway Placement and Spatial Reuse Problem), allows a much more efficient use of the available resources and reduces overall gateway costs. This article presents for the first time a mathematical formulation of the problem and discusses its advantages and limitations with respect to other approaches. 相似文献
46.
Rule cubes for causal investigations 总被引:1,自引:1,他引:0
Axel Blumenstock Franz Schweiggert Markus Müller Carsten Lanquillon 《Knowledge and Information Systems》2009,18(1):109-132
With the complexity of modern vehicles tremendously increasing, quality engineers play a key role within today’s automotive
industry. Field data analysis supports corrective actions in development, production and after sales support. We decompose
the requirements and show that association rules, being a popular approach to generating explanative models, still exhibit
shortcomings. Interactive rule cubes, which have been proposed recently, are a promising alternative. We extend this work
by introducing a way of intuitively visualizing and meaningfully ranking them. Moreover, we present methods to interactively
factorize a problem and validate hypotheses by ranking patterns based on expectations, and by browsing a cube-based network
of related influences. All this is currently in use as an interactive tool for warranty data analysis in the automotive industry.
A real-world case study shows how engineers successfully use it in identifying root causes of quality issues.
相似文献
Axel BlumenstockEmail: |
47.
48.
Martin Weiglhofer Gordon Fraser Franz Wotawa 《Information and Software Technology》2009,51(11):1601-1617
Test purposes have been presented as a solution to avoid the state space explosion when selecting test cases from formal models. Although such techniques work very well with regard to the speed of the test derivation, they leave the tester with one important task that influences the quality of the overall testing process: test purposes have to be formulated manually. In this paper, we present an approach that assists a test engineer with test purpose design in two ways: it allows automatic generation of coverage based test suites and can be used to automatically exercise those aspects of the system that are missed by hand-crafted test purposes. We consider coverage of Lotos specifications, and show how labeled transition systems derived from such specifications have to be extended in order to allow the application of logical coverage criteria to Lotos specifications. We then show how existing tools can be used to efficiently derive test cases and suggest how to use the coverage information to minimize test suites while generating them. 相似文献
49.
Lutz Hofmann Tobias Fischer Thomas Werner Franz Selbmann Michael Rennau Ramona Ecke Stefan E. Schulz Thomas Geßner 《Microsystem Technologies》2016,22(7):1665-1677
This paper discusses approaches for the isolation of deep high aspect ratio through silicon vias (TSV) with respect to a Via Last approach for micro-electro-mechanical systems (MEMS). Selected TSV samples have depths in the range of 170…270 µm and a diameter of 50 µm. The investigations comprise the deposition of different layer stacks by means of subatmospheric and plasma enhanced chemical vapour deposition (PECVD) of tetraethyl orthosilicate; Si(OC2H5)4 (TEOS). Moreover, an etch-back approach and the selective deposition on SiN were also included in the investigations. With respect to the Via Last approach, the contact opening at the TSV bottom by means of a specific spacer-etching method have been addressed within this paper. Step coverage values of up to 74 % were achieved for the best of those approaches. As an alternative to the SiO2-isolation liners a polymer coating based on the CVD of Parylene F was investigated, which yields even higher step coverage in the range of 80 % at the lower TSV sidewall for a surface film thickness of about 1000 nm. Leakage current measurements were performed and values below 0.1 nA/cm2 at 10 kV/cm were determined for the Parylene F films which represents a promising result for the aspired application to Via Last MEMS-TSV. 相似文献
50.
Command governor for constrained switched systems with scheduled model transition dwell times 下载免费PDF全文
In this paper, a switched control architecture for constrained control systems is presented. The strategy is based on command governor ideas that are here specialized to ‘optimally’ schedule switching events on the plant dynamics for improving control performance at the expense of low computational burdens. The significance of the method mainly lies in its capability to avoid constraints violation and loss of stability regardless of any configuration change occurrence in the plant/constraint structure. To this end, the concept of model transition dwell time is used within the proposed control framework to formally define the minimum time necessary to enable a switching event under guaranteed conditions on the overall stability and constraint fulfilment. Simulation results on a simple linear system and on a Cessna 182 aircraft model show the effectiveness of the proposed strategy. Copyright © 2017 John Wiley & Sons, Ltd. 相似文献