Vertex angle and crossing angle resolution of leveled tree drawings

We study the problem of computing leveled tree drawings, i.e., straight-line drawings of trees where the vertices have distinct preassigned y-coordinates. Our optimization goal is to maximize the crossing angle resolution (i.e., the minimum angle formed by any two crossing edges) and/or the vertex angle resolution (i.e., the minimum angle formed by two edges incident to the same vertex) of the drawing. We provide tight and almost tight worst case bounds for the crossing angle resolution and for the total angle resolution (i.e., the minimum of crossing and vertex angle resolution), respectively.     

On-line schedulability tests for adaptive reservations in fixed priority scheduling

Adaptive reservation is a real-time scheduling technique in which each application is associated a fraction of the computational resource (a reservation) that can be dynamically adapted to the varying requirements of the application by using appropriate feedback control algorithms. An adaptive reservation is typically implemented by using an aperiodic server (e.g. sporadic server) algorithm with fixed period and variable budget. When the feedback law demands an increase of the reservation budget, the system must run a schedulability test to check if there is enough spare bandwidth to accommodate such increase. The schedulability test must be very fast, as it may be performed at each budget update, i.e. potentially at each instance of a task; yet, it must be as efficient as possible, to maximize resource usage. In this paper, we tackle the problem of performing an efficient on-line schedulability test for adaptive resource reservations in fixed priority schedulers. In the literature, a number of algorithms have been proposed for on-line admission control in fixed priority systems. We describe four of these tests, with increasing complexity and performance. In addition, we propose a novel on-line test, called Spare-Pot algorithm, which has been specifically designed for the problem at hand, and which shows a good cost/performance ratio compared to the other tests.     

A2A Receptor Dysregulation in Dystonia DYT1 Knock-Out Mice

We aimed to investigate A2A receptors in the basal ganglia of a DYT1 mouse model of dystonia. A2A was studied in control Tor1a+/+ and Tor1a+/− knock-out mice. A2A expression was assessed by anti-A2A antibody immunofluorescence and Western blotting. The co-localization of A2A was studied in striatal cholinergic interneurons identified by anti-choline-acetyltransferase (ChAT) antibody. A2A mRNA and cyclic adenosine monophosphate (cAMP) contents were also assessed. In Tor1a+/+, Western blotting detected an A2A 45 kDa band, which was stronger in the striatum and the globus pallidus than in the entopeduncular nucleus. Moreover, in Tor1a+/+, immunofluorescence showed A2A roundish aggregates, 0.3–0.4 μm in diameter, denser in the neuropil of the striatum and the globus pallidus than in the entopeduncular nucleus. In Tor1a+/−, A2A Western blotting expression and immunofluorescence aggregates appeared either increased in the striatum and the globus pallidus, or reduced in the entopeduncular nucleus. Moreover, in Tor1a+/−, A2A aggregates appeared increased in number on ChAT positive interneurons compared to Tor1a+/+. Finally, in Tor1a+/−, an increased content of cAMP signal was detected in the striatum, while significant levels of A2A mRNA were neo-expressed in the globus pallidus. In Tor1a+/−, opposite changes of A2A receptors’ expression in the striatal-pallidal complex and the entopeduncular nucleus suggest that the pathophysiology of dystonia is critically dependent on a composite functional imbalance of the indirect over the direct pathway in basal ganglia.     

Engineered Lactobacillus paracasei Producing Palmitoylethanolamide (PEA) Prevents Colitis in Mice

Palmitoylethanolamide (PEA) is an N-acylethanolamide produced on-demand by the enzyme N-acylphosphatidylethanolamine-preferring phospholipase D (NAPE-PLD). Being a key member of the larger family of bioactive autacoid local injury antagonist amides (ALIAmides), PEA significantly improves the clinical and histopathological stigmata in models of ulcerative colitis (UC). Despite its safety profile, high PEA doses are required in vivo to exert its therapeutic activity; therefore, PEA has been tested only in animals or human biopsy samples, to date. To overcome these limitations, we developed an NAPE-PLD-expressing Lactobacillus paracasei F19 (pNAPE-LP), able to produce PEA under the boost of ultra-low palmitate supply, and investigated its therapeutic potential in a murine model of UC. The coadministration of pNAPE-LP and palmitate led to a time-dependent release of PEA, resulting in a significant amelioration of the clinical and histological damage score, with a significantly reduced neutrophil infiltration, lower expression and release of pro-inflammatory cytokines and oxidative stress markers, and a markedly improved epithelial barrier integrity. We concluded that pNAPE-LP with ultra-low palmitate supply stands as a new method to increase the in situ intestinal delivery of PEA and as a new therapeutic able of controlling intestinal inflammation in inflammatory bowel disease.     

Further Results to Time-Dependent Local Scour at Bridge Elements

This research intends to clarify the limitations of a local scour equation recently proposed, based on extended laboratory data collected at VAW, Zurich, Switzerland. The present project is concerned with four items: (1) clarification of the minimum laboratory dimensions required to apply Froude similitude; (2) effect of sloping abutments on scour advance; (3) extension of scour formula to spur dikes; and (4) effect of unsteady flow on scour development. These items were investigated mainly from an experimental point of view based on some 150 laboratory experiments and accounted for by a hydraulic approach. It was found that the basic scour equation mentioned may be applied provided additional limitations are specified. These are discussed in the light of the densimetric particle Froude number, the threshold Froude number, and other important parameters that influence the progress of local scour. The results of this study may be applied to practice, provided the limitations of the computational approach are respected.     

Progressive crushing of fiber-reinforced composite structural components of a Formula One racing car

The present paper describes an experimental and numerical investigation on energy absorbers for Formula One side impact and steering column impact. The crash tests are performed measuring the load-shortening diagram and the energy absorbed by the structure. A finite element model is then developed using the non-linear, explicit dynamic code LS-DYNA. To set up the numerical model, tubes crushing testing are conducted to determine the material failure modes and to characterise them with LS-DYNA. The results presented in this study show that the composite structural components of the investigated Formula One racing car possess high value of specific absorbed energy and crash load efficiency around 1.1. The finite element simulations accurately predict the overall shape, magnitude and pulse duration in all the types of impact as well as the deformation and failure of the structures. Comparing the numerical data of the specific absorbed energy to the experimental results, the differences are around 10%.     

CNN‐based architecture for real‐time object‐oriented video coding applications

This paper presents a new CNN‐based architecture for real‐time video coding applications. The proposed approach, by exploiting object‐oriented CNN algorithms and MPEG encoding capabilities, enables low bit‐rate encoder/decoder to be designed. Simulation results using Claire video sequence show the effectiveness of the proposed scheme. Copyright © 2005 John Wiley & Sons, Ltd.     

Towards Syntax-Aware Editors for Visual Languages

Editors for visual languages should provide a user-friendly environment supporting end users in the composition of visual sentences in an effective way. Syntax-aware editors are a class of editors that prompt users into writing syntactically correct programs by exploiting information on the visual language syntax. In particular, they do not constrain users to enter only correct syntactic states in a visual sentence. They merely inform the user when visual objects are syntactically correct. This means detecting both syntax and potential semantic errors as early as possible and providing feedback on such errors in a non-intrusive way during editing. As a consequence, error handling strategies are an essential part of such editing style of visual sentences.In this work, we develop a strategy for the construction of syntax-aware visual language editors by integrating incremental subsentence parsers into free-hand editors. The parser combines the LR-based techniques for parsing visual languages with the more general incremental Generalized LR parsing techniques developed for string languages. Such approach has been profitably exploited for introducing a noncorrecting error recovery strategy, and for prompting during the editing the continuation of what the user is drawing.