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951.
Marilena Pariano Stefania Pieroni Antonella De Luca Rossana G. Iannitti Monica Borghi Matteo Puccetti Stefano Giovagnoli Giorgia Renga Fiorella DOnofrio Marina M. Bellet Claudia Stincardini Maria Agnese Della-Fazia Giuseppe Servillo Frank L. van de Veerdonk Claudio Costantini Luigina Romani 《International journal of molecular sciences》2021,22(12)
952.
Giuseppe Pezzotti † Ken'ichi Ota Hans-Joachim Kleebe 《Journal of the American Ceramic Society》1996,79(9):2237-2246
Internal friction, torsional creep, and shear modulus relaxation experiments were conducted on a model Si3 N4 polycrystalline material, which contained a continuous amorphous film of pure SiO2 at the grain boundary. Internal friction experiments were performed in the frequency range between 3 and 13 Hz, in 5 Pa of nitrogen atmosphere. Very high temperatures (up to 2000°C) could be applied for the first time by using a newly developed torsional pendulum apparatus. This apparatus was also capable of precise torsional strain measurements under static-load conditions. The internal friction curves at various frequencies were generally found to consist of a grain-boundary peak super-imposed on an exponential-like background. The peak, of anelastic diffusive origin, was centered in the temperature range of 1612–1710°C depending on the frequency of the measurement, namely within an interval of about 100°C below the nominal melting point of the pure SiO2 phase (i.e., ∼ 1730°C). The background was instead found to be of viscoelastic nature. A common micromechanical origin between the creep plastic strain and the internal friction background curves was identified and the data could be fitted by the same Arrhenius plot. Structural and chemical characterization of internal grain boundaries was performed by high-resolution electron microscopy (HREM) in addition to electron energy-loss spectroscopy (EELS). A small amount of nitrogen was detected within the amorphous residue along grain boundaries. According to the above set of microstructural/chemical and mechanical data, the viscosity properties of the intergranular phase were assessed and the sliding mechanism between adjacent Si3 N4 grains was modeled. 相似文献
953.
Giuseppe Esposito Marcella Pesce Luisa Seguella Jie Lu Chiara Corpetti Alessandro Del Re Fatima Domenica Elisa De Palma Giovanni Esposito Walter Sanseverino Giovanni Sarnelli 《International journal of molecular sciences》2021,22(6)
Palmitoylethanolamide (PEA) is an N-acylethanolamide produced on-demand by the enzyme N-acylphosphatidylethanolamine-preferring phospholipase D (NAPE-PLD). Being a key member of the larger family of bioactive autacoid local injury antagonist amides (ALIAmides), PEA significantly improves the clinical and histopathological stigmata in models of ulcerative colitis (UC). Despite its safety profile, high PEA doses are required in vivo to exert its therapeutic activity; therefore, PEA has been tested only in animals or human biopsy samples, to date. To overcome these limitations, we developed an NAPE-PLD-expressing Lactobacillus paracasei F19 (pNAPE-LP), able to produce PEA under the boost of ultra-low palmitate supply, and investigated its therapeutic potential in a murine model of UC. The coadministration of pNAPE-LP and palmitate led to a time-dependent release of PEA, resulting in a significant amelioration of the clinical and histological damage score, with a significantly reduced neutrophil infiltration, lower expression and release of pro-inflammatory cytokines and oxidative stress markers, and a markedly improved epithelial barrier integrity. We concluded that pNAPE-LP with ultra-low palmitate supply stands as a new method to increase the in situ intestinal delivery of PEA and as a new therapeutic able of controlling intestinal inflammation in inflammatory bowel disease. 相似文献
954.
955.
Lorenzo Lisuzzo Giuseppe Cavallaro Filippo Parisi Stefana Milioto Giuseppe Lazzara 《Ceramics International》2019,45(2):2858-2865
The colloidal stability of halloysite clay nanotubes dispersion is reviewed showing the strategy and the mechanism to obtain stable systems in water and apolar solvents. The selective modification of halloysite inner/outer surfaces can be achieved by exploiting electrostatic interactions. The adsorption of anionic surfactants onto the halloysite cavity allows generating inorganic cylindrical micelles that can be separated from the solvent. On the other hand, the functionalization of halloysite shell by positively charged surfactants drives to obtain stable water-in-oil emulsions. The interactions with ionic and nonionic polymers alters the dispersability of halloysite due to electrostatic and steric effects that are strongly dependent on the nanoarchitecture of the hybrid systems.Modified nanotubes by selective interactions lead to the formation of colloidal systems with tuneable surface properties and controlled colloidal stability adjusted to the solvent polarity. These dispersions are perspectives nanocarriers for substances such as antioxidants, biocides, drugs and corrosion inhibitors, to be released in response to external stimuli. 相似文献
956.
Gian Paolo Caviglia Chiara Rosso Angelo Armandi Melania Gaggini Fabrizia Carli Maria Lorena Abate Antonella Olivero Davide Giuseppe Ribaldone Giorgio Maria Saracco Amalia Gastaldelli Elisabetta Bugianesi 《International journal of molecular sciences》2020,21(22)
Background: Pathogenetic mechanisms involved in the progression of non-alcoholic fatty liver disease (NAFLD) are complex and multifactorial. We investigated oxidative stress through the measurement of selenoprotein P (SeP) in serum and we explored its relation to metabolic derangements and liver damage in a group of non-diabetic NAFLD subjects. Methods: 57 NAFLD patients underwent a double-tracer oral glucose tolerance test (OGTT). Insulin resistance (IR) components were calculated at baseline as follows: hepatic-IR = (endogenous glucose production*insulin); peripheral-IR = (glucose rate of disappearance(Rd)); adipose-tissue(AT)-IR as Lipo-IR = (glycerol rate of appearance (Ra)*insulin) or AT-IR = (free fatty acids (FFAs)*insulin). The lipid and amino acid (AA) profiles were assessed by gas chromatography–mass spectrometry. SeP levels were measured by enzyme immunosorbent assay. Results: Circulating SeP correlated with insulin (rS = 0.28), FFAs (rS = 0.42), glucose Rd (rS = −0.33) and glycerol Ra (rS = −0.34); consistently, SeP levels correlated with Lipo-IR and AT-IR (rS > 0.4). Among the AA and lipid profiles, SeP inversely correlated with serine (rS = −0.31), glycine (rS = −0.44) and branched chain AA (rS = −0.32), and directly correlated with saturated (rS = 0.41) and monounsaturated FFAs (rS = 0.40). Hepatic steatosis and fibrosis increased in subjects with higher levels of SeP. In multivariable regression analysis, SeP was associated with the degree of hepatic fibrosis (t = 2.4, p = 0.022). Conclusions: SeP levels were associated with an altered metabolic profile and to the degree of hepatic fibrosis, suggesting a role in the pathogenesis of NAFLD. 相似文献
957.
Giuseppe Pezzotti 《Journal of the American Ceramic Society》2001,84(10):2225-2228
Internal friction characterization has been used to quantitatively assess the viscosity characteristics of Si-O-C-N glasses segregated to nanometer-sized grain boundaries of polycrystalline Si3 N4 and SiC ceramics. A relaxation peak of internal friction, which arises with rising temperature from the viscous sliding of glassy grain boundaries, was systematically collected and analyzed with respect to its shift upon changing the oscillation frequency. As a result of such an analysis, both activation energy for viscous grain-boundary flow and inherent viscosity of the intergranular glass film could be quantitatively evaluated. Two main features are shown: (i) the presence of N and/or C greatly affects the viscosity characteristics of SiO2 phases at Si3 N4 and SiC grain boundaries; and (ii) the internal friction method has potential as a unique experimental tool for understanding the local properties of nanoscale amorphous phases in new ceramic materials. 相似文献
958.
Giuseppe Pezzotti Hiroyuki Ichimaru Luca Paolo Ferroni Kiyoshi Hirao Orfeo Sbaizero 《Journal of the American Ceramic Society》2001,84(8):1785-1790
The microscopic bridging stress distribution developed behind the crack tip of a highly anisotropic silicon nitride has been measured along the crack profile using Raman microprobe spectroscopy with a micrometer spatial resolution. The near-tip rising R -curve behavior and the crack-opening displacement (COD) profile of the material were also determined and discussed in comparison with the Raman microstress data. A comparison with the fracture behavior of a previously investigated silicon nitride material with a three-dimensional random microstructure is also proposed. According to this set of micro/macroscopic fracture characterizations, a self-consistent view of toughening behavior in silicon nitride ceramics is obtained, and the role on toughness of anisotropically oriented acicular grains clarified. In agreement with previous studies, it is confirmed that crack-face bridging is the most effective mechanism for toughening silicon nitride ceramics. 相似文献
959.
Shrikant N. Khot John J. Lascala Erde Can Shantaram S. Morye George I. Williams Giuseppe R. Palmese Selim H. Kusefoglu Richard P. Wool 《应用聚合物科学杂志》2001,82(3):703-723
Triglyceride oils derived from plants have been used to synthesize several different monomers for use in structural applications. These monomers have been found to form polymers with a wide range of physical properties. They exhibit tensile moduli in the 1–2 GPa range and glass transition temperatures in the range 70–120 °C, depending on the particular monomer and the resin composition. Composite materials were manufactured utilizing these resins and produced a variety of durable and strong materials. At low glass fiber content (35 wt %), composites produced from acrylated epoxidized soybean oil by resin transfer molding displayed a tensile modulus of 5.2 GPa, a flexural modulus of 9 GPa, a tensile strength of 129 MPa, and flexural strength of 206 MPa. At higher fiber contents (50 wt %) composites produced from acrylated epoxidized soybean oil displayed tensile and compression moduli of 24.8 GPa each, and tensile and compressive strengths of 463.2 and 302.6 MPa, respectively. In addition to glass fibers, natural fibers such as flax and hemp were used. Hemp composites of 20% fiber content displayed a tensile strength of 35 MPa and a tensile modulus of 4.4 GPa. The flexural modulus was ∼2.6 GPa and the flexural strength was in the range 35.7–51.3 MPa, depending on the test conditions. The flax composite materials had tensile and flexural strengths in the ranges 20–30 and 45–65 MPa, respectively. The properties exhibited by both the natural- and synthetic fiber-reinforced composites can be combined through the production of “hybrid” composites. These materials combine the low cost of natural fibers with the high performance of synthetic fibers. Their properties lie between those displayed by the all-glass and all-natural composites. Characterization of the polymer properties also presents opportunities for improvement through genetic engineering technology. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 703–723, 2001 相似文献
960.
Marianna Abate Lorena Scotti Valeria Nele Michele Caraglia Marco Biondi Giuseppe De Rosa Carlo Leonetti Virginia Campani Silvia Zappavigna Manuela Porru 《International journal of molecular sciences》2022,23(9)
Self-assembling nanoparticles (SANPs) promise an effective delivery of bisphosphonates or microRNAs in the treatment of glioblastoma (GBM) and are obtained through the sequential mixing of four components immediately before use. The self-assembling approach facilitates technology transfer, but the complexity of the SANP preparation protocol raises significant concerns in the clinical setting due to the high risk of human errors during the procedure. In this work, it was hypothesized that the SANP preparation protocol could be simplified by using freeze-dried formulations. An in-depth thermodynamic study was conducted on solutions of different cryoprotectants, namely sucrose, mannitol and trehalose, to test their ability to stabilize the produced SANPs. In addition, the ability of SANPs to deliver drugs after lyophilization was assessed on selected formulations encapsulating zoledronic acid in vitro in the T98G GBM cell line and in vivo in an orthotopic mouse model. Results showed that, after lyophilization optimization, freeze-dried SANPs encapsulating zoledronic acid could retain their delivery ability, showing a significant inhibition of T98G cell growth both in vitro and in vivo. Overall, these results suggest that freeze-drying may help boost the industrial development of SANPs for the delivery of drugs to the brain. 相似文献