Exploring gate-limited analytical models for high-performance network storage servers

Gate-limited service is a type of service discipline found in queueing theory and can be used to describe a number of operational environments, for example, large transport systems such as buses, trains or taxis, etc. Recently, there has been the observation that such systems can also be used to describe interactive Internet Services which use a Client/Server interaction. In addition, new services of this genre are being developed for the local area. One such service is a Network Memory Server (NMS) being developed here at Middlesex University. Though there are several examples of real systems that can be modelled using gate-limited service, it is fair to say that the analytical models which have been developed for gate-limited systems have been difficult to use, requiring many iterations before practical results can be generated. In this paper, a detailed gate-limited bulk service queueing model based on Markov chains is explored and a numerical solution is demonstrated for simple scenarios. Quantitative results are presented and compared with a mathematical simulation. The analysis is used to develop an algorithm based on the concept of optimum operational points. The algorithm is then employed to build a high-performance server which is capable of balancing the need to prefetch for streaming applications while promptly satisfying demand misses. The algorithm is further tested using a systems simulation and then incorporated into an Experimental File System (EFS) which showed that the algorithm can be used in a real networking environment.     

Focally regulated endothelial proliferation and cell death in human synovium

Angiogenesis and vascular insufficiency each may support the chronic synovial inflammation of rheumatoid arthritis. We have shown by quantitative immunohistochemistry and terminal uridyl deoxynucleotide nick end labeling that endothelial proliferation and cell death indices were each increased in synovia from patients with rheumatoid arthritis compared with osteoarthritic and noninflamed controls, whereas endothelial fractional areas did not differ significantly among disease groups. Markers of proliferation were associated with foci immunoreactive for vascular endothelial growth factor and integrin alpha(v)beta3, whereas cell death was observed in foci in which immunoreactivities for these factors were weak or absent. No association was found with thrombospondin immunoreactivity. The balance between angiogenesis and vascular regression in rheumatoid synovitis may be determined by the focal expression of angiogenic and endothelial survival factors. Increased endothelial cell turnover may contribute to microvascular dysfunction and thereby facilitate persistent synovitis.