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CH Damsky A Moursi Y Zhou SJ Fisher RK Globus 《Canadian Metallurgical Quarterly》1997,51(5):1427-1433
Cell interactions with extracellular matrix and with other cells play critical roles in morphogenesis during development and in tissue homeostasis and remodeling throughout life. Extracellular matrix is information-rich, not only because it is comprised of multifunctional structural ligands for cell surface adhesion receptors, but also because it contains peptide signaling factors, and proteinases and their inhibitors. The functions of these groups of molecules are extensively interrelated. In this review, three primary cell culture models are described that focus on adhesion receptors and their roles in complex aspects of morphogenesis and remodeling: the regulation of proteinase expression by fibronectin and integrins in synovial fibroblasts; the regulation of osteoblast differentiation and survival by fibronectin, and the regulation of trophoblast differentiation and invasion by integrins, cadherins and immunoglobulin family adhesion receptors. 相似文献
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Improving detection sensitivity of biological molecules with low absorption characteristics in the terahertz gap still remains
an important issue in terahertz vibrational resonance spectroscopy. One possible way to increase coupling of incident terahertz
radiation to molecules is to exploit local enhancement of electromagnetic field in periodic slot arrays. In this work, we
show that periodic arrays of rectangular slots with subwavelength widths provide for local electromagnetic field enhancements
due to edge effects in our low frequency range of interest, 10–25 cm−1. Periodic structures of Au doped Si and InSb were studied. The half power enhancement width is ∼500 nm or less around the
slot, edges in all cases, thereby possibly bringing terahertz sensing to the nanoscale. InSb is confirmed to offer the highest
results with local power enhancements on the order of 1100 at frequency 14 cm−1. InSb and Si have large skin depths in our frequency range of interest and so the analysis of their structures was done through
the Fourier expansion method of field diffracted from gratings. Surface impedance boundary conditions were employed to model
the Au structure. The applications possibly include development of novel biosensors, and monitoring biophysical processes
such as DNA denaturation.
The text was submitted by the authors in English. 相似文献
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New criterial relations are obtained with allowance for the influence of thermal gradient mass transfer, phase transitions and Kossovich number on the inertia of heat and mass transfer processes. 相似文献