Low voltage low power fully differential self‐biased 1.5‐bit quantizer with built‐in thresholds

A new fully differential self‐biased 1.5‐bit flash quantizer with built‐in threshold voltages, suitable for high speed ADCs and low voltage operation, is described. The proposed circuit is very simple, and simulation results in a 65 nm standard CMOS technology demonstrate that, following the suggested design methodology, it is able to achieve low offset, low kickback noise, low metastability probability errors and fast regeneration time with very low power dissipation. Copyright © 2011 John Wiley & Sons, Ltd.     

A reference-free 7-bit 500 MS/s pipeline ADC using current-mode reference shifting and quantizers with built-in thresholds

The pursuit for energy and area efficient circuits has become greater than ever. Low power and small area integrated circuits are in high demand today. Reference voltage circuitry for analog-to-digital conversion comprises 20–30 % of the overall power and area of the ADC. To this end, a fully differential 1.5-bit multiplying digital-to-analog converter (MDAC) precluding reference voltages, that can be employed in MDAC-based ADCs, is presented. Reference shifting is performed in current-mode and the gain of two is obtained by associating charged capacitors in series in the opamp’s feedback loop, achieving a unity feedback factor. Theoretical analyses of various nonideal effects of the reference shifting and gain of two are presented and confirmed with electrical level simulations. Furthermore, to avoid reference voltages in the local quantizers, an architecture with built-in thresholds is used. A proof of concept 1.5-bit/stage 7-bit 500 MS/s pipeline ADC is designed using the proposed MDAC in a standard digital 0.13 μm CMOS technology. The ADC achieves a peak SNDR and SFDR of 36.1 and 48.7 dB, respectively, while dissipating 12.7 mW from a single 1.2 V supply voltage, and it does not require external reference circuitry.     

Determination of free and conjugated oestrogens in peripheral blood plasma, feces and urine of cattle throughout pregnancy

In order to further characterize oestrogen production and metabolism during bovine pregnancy, free (f) and conjugated (c) estrone (E1), total free and conjugated oestrogens (tfcOe) and total free oestrogens (tfOe) were determined as marker oestrogens in blood plasma respectively in urine and feces of 10 pregnant cows. For the determination of individual oestrogens blood, urine and feces samples of days 240, 200, 160, 100, 60, 30, 10 and 5 prior to parturition were pooled and the free, sulfo (sc)- and glucuconjugated (gc) forms of E1, 17 beta-estradiol (E2 beta) and 17 alpha-estradiol (E2 alpha) were obtained following differential enzyme hydrolysis and separation by HPLC; hormone assay was by established RIA-procedures. FE1 and cE1 concentration in blood plasma, tfOe in feces and tfcOe in urine showed a similar pattern. A first rise occurred between days 110 and 120 of pregnancy, an additional overproportional rise commenced at around days 230-250. Highest concentrations were measured in feces (tfOe ca. 500 ng/g 1 day a. p.), followed by urine (tfcOe ca. 3.5 ng/mosmol 2 days a. p.) and blood plasma (fE1 ca. 8 nmol/l and cE1 ca. 20 nmol/l 2 days a. p.). Determination of individual oestrogens in blood plasma revealed that fE2 beta and fE2 alpha could only be found 10 days a. p. while the conjugated forms could already be detected on days 100 and 160 a. p. With 62% E1 was the dominant oestrogen, followed by E2 alpha (37%) and E2 beta (1.0%); E1 occurred predominantly as sulfate, E2 alpha and E2 beta predominantly as glucuronide. Main metabloite in feces was fE2 alpha (56.7%), followed by fE2 beta (32%) and fE1 (11.3%); conjugated oestrogens were not detected. Main metabolite in urine was scE1 followed by gcE2 alpha and gcE2 beta. ScE2 alpha and scE2 beta were not detected or were present in small quantities only. Hormonal changes over time were highly significant. Main product of placental oestrogen synthesis is scE1, the concentrations of f and c E2 beta and E2 alpha in plasma largely result from oestrogen metabolism and enterohepatic circulation.     

An Optimal Transport Approach to Robust Reconstruction and Simplification of 2D Shapes

We propose a robust 2D shape reconstruction and simplification algorithm which takes as input a defect‐laden point set with noise and outliers. We introduce an optimal‐transport driven approach where the input point set, considered as a sum of Dirac measures, is approximated by a simplicial complex considered as a sum of uniform measures on 0‐ and 1‐simplices. A fine‐to‐coarse scheme is devised to construct the resulting simplicial complex through greedy decimation of a Delaunay triangulation of the input point set. Our method performs well on a variety of examples ranging from line drawings to grayscale images, with or without noise, features, and boundaries.     

Low-power low-voltage CMOS A/D sigma-delta modulator for bio-potential signals driven by a single-phase scheme

Since the 1970's, the analog switches in switched-capacitor (SC) circuits are operated by nonoverlapping bi-phase control signals (/spl phi//sub 1/, /spl phi//sub 2/). The nonoverlapping of these two phases is essential for successful SC operation since, a capacitor inside an SC circuit can discharge if two switches, driven by /spl phi//sub 1/ and /spl phi//sub 2/, are turned on simultaneously. Moreover, since 1983, two additional phases are generally used in many SC circuits, which consist of advanced versions of /spl phi//sub 1/ and /spl phi//sub 2/. These two additional phases overcome the problem of signal-dependent charge injection. This paper presents a low-power and low-voltage analog-to-digital (A/D) interface module for biomedical applications. This module provides an A/D conversion based on a mixed clock-boosting/switched-opamp (CB/SO) second-order sigma-delta (/spl Sigma//spl Delta/) modulator, capable of interfacing with several different types electrical signals existing in the human body, only by re-programming the output digital filter. The proposed /spl Sigma//spl Delta/ architecture employs a novel single-phase scheme technique, which improves the dynamic performance and highly reduces the clocking circuitry complexity, substrate noise and area. Simulated results demonstrate that the signal integrity can be preserved by exploring the gap between the high conductance region of pMOS and nMOS switches at low power-supply voltages and the fast clock transitions that exist in advanced CMOS technologies. The mixed CB/SO architecture together with the overall distortion reduction resulting from using the proposed single-phase scheme, result that the dynamic range of the modulator is pushed closer to the theoretical limit of an ideal second-order /spl Sigma//spl Delta/ modulator.     

Improving the dispersion of MWCNT and MMT in PVDF melts employing controlled extensional flows

Poly (vinylidene fluoride) (PVDF) has been widely explored to produce polymer nanocomposites possessing outstanding combinations of properties. In this work, the impact of extensional melt flows on the dispersion, relaxation and crystallinity of PVDF nanocomposites filled with multiwalled carbon nanotubes (MWCNT) and montmorillonites (MMT) was studied. Extrusion was employed to produce nanocomposites containing 3 wt% of fillers, named: (i) PVDF/3 wt% MWCNT, (ii) PVDF/3wt%MMT, and (iii) PVDF/1.5wt%MWCNT/1.5 wt% MMT. The results showed that applying a sequence of extensional flows through the melts improved the dispersion of both fillers in the PVDF matrix. Moreover, extensional flows significantly enhanced the viscosity and relaxation of MWCNT nanocomposite, but had marginal effects on MMT nanocomposite. On the other hand, MMT favored the crystallization of the β piezoelectric phase of PVDF over the α phase and the extensional flow enhanced its crystallinity content. Therefore, these new insights prospect a vast horizon toward the use of extensional flows for tailoring synergic combinations of properties in hybrid PVDF/MWCNT/MMT systems.     

Effect of surfactants on α‐amylase production in a solid substrate fermentation process

Solid substrate fermentation (SSF) is a process where the substrate is a moist solid, which is insoluble in water but not suspended in water. In this study SSF of Bacillus subtilis (ATCC 21556) was used to produce an enzyme of commercial importance, α‐amylase, using as a substrate potato peel. To enhance the production of this enzyme, two nonionic synthetic surfactants were used, Tween 80 and Tween 20, one anionic surfactant, SDS at concentrations of 0.05% and 0.10% (v/w) and a biosurfactant produced by Bacillus subtilis (ATCC 21332), known as surfactin, at concentrations of 0.003%, 0.007%, 0.013% and 0.03% (w/w). The results have shown that surfactants significantly increase the production of α‐amylase. Tween 80 at 0.10% and surfactin at 0.013% provided the highest enzyme activity when compared with the control. © 1999 Society of Chemical Industry     

Modelling the evolution of residual stresses during tensile testing of elastoplastic wires subjected to a previous bending operation

During coiling operations high residual stresses are frequently developed in steel wire. In this paper the stress distribution in wires during coiling, unwinding and subsequent tensile testing is modelled for numerous bending degrees, assuming perfect Voce plastic deformation and linear elastic behaviour. The influence of such residual stresses on the observed tensile test data can be deduced. It is shown that coiling with spool radii as used today industrially can lead to measurement of wire properties deviating significantly from the “true” properties of a properly coiled wire. Also, a method is proposed to deduce the original flow behaviour of coiled samples from tensile test curves, hence filtering the effect of the residual stresses.     

Primary osteoblast cell response to sol-gel derived bioactive glass foams

Bioactive glass macroporous structures were developed in this work to be used as scaffolds for bone tissue engineering applications. A sol-gel route was used to obtain glass foams with the introduction of a gas phase in the solution and by vigorous agitation of the sol-gel solution that contains a foam agent. Stable and homogeneous foams were formed near the gelation point, which were than dried and heat-treated. Macroporous structures with interconnected pores of up to 500 μ m, porosity as high as 88% and specific surface area of 92 m²/g were obtained. The porous glasses were tested in osteoblast cultures to evaluate adhesion, proliferation, collagen and alkaline phosphatase production. Osteoblast proliferation was higher in the presence of the foams as well as was the collagen secretion, when compared to control. The alkaline phosphatase production was not altered. Viable osteoblasts could be seen inside the foams, suggesting that the produced porous glass foams are a promising materials for bone repair, since it provides a good environment for the adhesion and proliferation of osteoblasts.     

Analysis of Fusarium causing dermal toxicosis in marram grass planters

This study estimates the costs of clinical follow-up for women with early stage breast cancer and evaluates the effects of patient and provider characteristics on follow-up intensity. Claims data were cumulated from 1/1/89 through 4/30/93 for a comprehensive set of follow-up tests (office visits, radiologic, and laboratory) ordered for 222 women diagnosed at a university hospital between 1/1/89 and 12/31/91. Aggregated measures of the volume and costs of follow-up over 6 month intervals were expressed in terms of Medicare's 1993 relative value units (RVUs) and their 1993 cost equivalents. Excluding the first 6 months, women received on average, 11.7 RVUs of follow-up in the first year (equivalent to a cost of $362), and 9.5 RVUs in the second year ($297). In the first year, chest x-rays, clinical chemistry tests, automated hemograms, and bone scans, accounted for 36% of the cost of follow-up, while computerized tomographic scans and magnetic resonance imaging studies accounted for 30%. Multiple regression analysis of the first year data showed that women who received radiation and/or were followed by oncology, were more likely to receive intensive follow-up. Age, race, socioeconomic status, insurance, stage, and treatment did not impact follow-up. Costs of follow-up for breast cancer are substantial, though much lower than suggested by others. Additionally, wide variations in practice are largely unexplained by patient and/or provider characteristics. In light of recent evidence questioning the benefit of intensive surveillance, this study supports the need for an accepted set of follow-up guidelines for breast cancer.