Adaptive control strategy for regulation of blood glucose levels in patients with type 1 diabetes

Current insulin therapy for patients with type 1 diabetes often results in high variability in blood glucose concentrations and may cause hyperglycemic/hypoglycemic episodes. Closing the glucose control loop with a fully automated electro-mechanical pancreas will improve the quality of life for insulin-dependent patients. An adaptive control algorithm is proposed to keep glucose concentrations within normoglycemic range and dynamically respond to glycemic challenges. A model-based control strategy is used to calculate the required insulin infusion rate, while the model parameters are recursively tuned. The algorithm handles delays associated with insulin absorption, time-lag between subcutaneous and blood glucose concentrations, and variations in inter/intra-subject glucose–insulin dynamics. Simulation results for simultaneous meal and physiological disturbances are demonstrated for subcutaneous insulin infusion.     

The crack and wedging problem for an orthotropic strip

In this paper the plane elasticity problem for an orthotropic strip containing a crack parallel to its boundaries is first considered. The problem is formulated under general mixed mode loading conditions. It is shown that the stress intensity factors depend on two dimensionless orthotropic constants only. For the crack problem the results are given for a single crack and two collinear cracks. The calculated results show that of the two orthotropic constants the influence of the stiffness ratio on the stress intensity factors is much more significant than that of the shear parameter. The problem of loading the strip by a rigid rectangular wedge is then considered. It is found that for relatively small wedge lengths continuous contact is maintained along the wedge-strip interface, at a certain critical wedge length the separation starts at the midsection of the wedge, and the length of the separation zone increases rapidly with increasing wedge length.

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Résumé Dans ce mémoire, le problème d'élasticité plane relatif à une bande orthotropique contenant une fissure parallèle à ses bords est considéré en premier lieu. Le problème est formulé pour des conditions générales de charge de mode mixte. On montre que les facteurs d'intensité de contrainte dépendent seulement de deux constantes orthotropiques sans dimension. Pour le problème de fissuration, les résultats sont fournis dans le cas d'une fissure simple et de deux fissures colinéaires. Les résultats calculés montrent que des deux constantes orthotropiques, c'est l'influence du rapport de rigidité sur les facteurs d'intensité de contrainte qui est beaucoup plus significative que celle du paramètre de cisaillement. Le problème de mise en charge de la bande par un coin rectangulaire rigide est ensuite considéré. On montre que pour des longueurs de coin relativement petites, un contact continu est maintenu le long de l'interface entre le coin et la bande. Pour une certaine longueur critique du coin, la séparation se produit à mi-section du coin et la longueur de la zone de séparation s'accroît rapidement lorsque augmente la longueur du coin.

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This work was supported by NASA-Langley under the Grant NGR 39-007-011.     

Vibrational control of an exothermic CSTR: productivity improvementby multiple input oscillations

A. Cinar et al. (1987) have shown that vibrational control of an exothermic continuous stirred tank reactor (CSTR) by vibrating the total flow rate modifies its behavior and leads to stabilized operation in its unstable steady-state region. Here, the effect of multiple vibrating inputs and the contribution of their phase shift are investigated. Theoretical and experimental results indicate productivity improvement and amplitude reduction in reactor temperature swings by vibrating both input flow rate and input concentrations     

Enterococcus faecalis endophthalmitis as a metastatic complication of hemodialysis vascular access‐related sepsis: A case report and review of the literature

Catheter and/or arteriovenous (A‐V) graft‐related bacteremia is an important cause of morbidity and mortality among hemodialysis (HD) patients. Endocarditis, septic arthritis, epidural abscess, septic embolism, and osteomyelitis are the most common complications of catheter and/or A‐V graft‐related bacteremia; however, endogenous endophthalmitis is rarely seen. To the best of our knowledge, Enterococcus faecalis is the first case report in this population. We hereby report a case of endogenous endophthalmitis caused by E. faecalis as a complication of catheter and/or A‐V graft‐related bacteremia in a diabetic patient, who was undergoing HD for 5 years. We also discuss the etiology, clinical features, and outcomes of endogenous endophthalmitis in HD patients with a brief review of the literature. Although broad‐spectrum parenteral (intravenous and intravitreal) antibiotics were used for 4 weeks, evisceration of the left eye could not be avoided. Endogenous endophthalmitis is a rare but rapidly blinding complication of catheter and/or A‐V graft‐related bacteremia in HD patients. It can develop as a result of silent catheter and/or A‐V graft infections, which may lead to recurrent bacteremia. E. faecalis should be considered as a pathogen in this population who had recent history of catheter or A‐V graft procedure.     

Active carbon/graphene hydrogel nanocomposites as a symmetric device for supercapacitors

Activated carbons (ACs) are successfully synthesized from Elaeagnus grain by a simple chemical synthesis methodology and demonstrated as novel, suitable supercapacitor electrode materials for graphene hydrogel (GH)/AC nanocomposites. GH/AC nanocomposites are synthesized via hydrothermal process at temperature of 180°C. The low-temperature thermal exfoliation approach is convenient for mass production of graphene hydrogel (GH) at low cost and it can be used as electrode material for energy storage applications. The GH/AC nanocomposites exhibit better electrochemical performances than the pure GH. Electrochemical performance of the electrodes is studied by cyclic voltammetry, and galvanostatic charge-discharge measurements in 1.0 M H₂SO₄ solution. A remarkable specific capacitance of 602.36 Fg^?1 (based on GH/AC nanocomposites for 0.4 g AC) is obtained at a scan rate of 1 mVs^?1 in 1 M H₂SO₄ solution and 155.78 Fg^?1 for GH. The specific capacitance was increased 3.87 times for GH/AC compared to GH electrodes. Moreover, the GH/AC nanocomposites for 0.2 g AC present excellent long cycle life with 99.8% specific capacitance retained after 1000 charge/discharge processes. Herein, ACs prepared from Elaeagnus grain are synthesized GH and AC supercapacitor device for high-performance electrical energy storage devices as a promising substitute to conventional electrode materials for EDLCs.     

Experimental investigation on the ball burnishing of carbon fiber reinforced polymer

The polymer-based materials are generally used in all industrial applications. Even if polymer bars can be machined easily, they need surface finishing treatment after the machining process. The ductile properties make coarse roughness on the surface that causes the elastic structure of polymer materials. The carbon fiber reinforced composite materials differ from polymer-based materials by high strength and stiffness. Its structure exhibits similar performances such as metallic materials. The effect of ball burnishing on the surface quality of rod workpiece was investigated in this study. To enhance the surface quality of high strength carbon fiber reinforced polymer rod workpiece, burnishing process was performed in three different parameters (force, feed rate, number of passes) and under four different mediums (dry, wet, boron oil, and mineral oil) conditions. The results of the experiments were analyzed, and optimum burnishing parameters were determined and discussed in detail. The best surface roughness value of the CFRP material used in the experiments was obtained as burnishing force: 250 N, feed rate: 0.05 mm/rev, four passes and wet medium. According to the results of variance analysis, it was found that the CFRP workpiece is the important leading factor for surface roughness with a contribution ratio of 62.47%.     

Two‐Photon Vertical‐Flow Lithography for Microtube Synthesis

Two‐photon vertical‐flow lithography is demonstrated for synthesis of complex‐shaped polymeric microtubes with a high aspect ratio (>100:1). This unique microfluidic approach provides rigorous control over the morphology and surface topology to generate thin‐walled (<1 µm) microtubes with a tunable diameter (1–400 µm) and pore size (1–20 µm). The interplay between fluid‐flow control and two‐photon lithography presents a generic high‐resolution method that will substantially contribute toward the future development of biocompatible scaffolds, stents, needles, nerve guides, membranes, and beyond.     

Adsorption of anionic surfactants onto sepiolite

Anionic surfactants constitute the main ingredients of detergents and a number of surfactant formulations used in a spectrum of diverse industries. The aim of this study is to examine the amenability of natural sepiolite to the adsorption of anionic surfactants, sodium dodecylsulfate (SDS) and sodium dodecylbenzenesulfonate (SDBS). Adsorption isotherms exhibit three regions with distinctly different slopes. The first region is characterized by the complexation of anionic surfactants with Mg2+ ions at the octahedral sheet or hydrogen bonding between the oxygen groups of anionic head groups of surfactant and H+ of the bound or zeolitic water. The Mg2+ ions released from sepiolite leads to the precipitation of magnesium salt of surfactant in the second region. The third region marks both the beginning of plateau region and micellar dissolution of the precipitate. The effect of temperature on surfactant adsorption for SDS/sepiolite system was utilized to calculate such thermodynamic parameters as the free energy of adsorption (DeltaG(ads)(degrees)) and the heat of adsorption (DeltaH(ads)(degrees)). The low value of DeltaH(ads)(degrees) (1.87 kJ/mol) is an evidence for the physical adsorption of anionic surfactants onto sepiolite. The relatively large value of entropic contribution (-TDeltaS(ads)(degrees)) indicates that the adsorption of anionic surfactants onto sepiolite is entropically governed.