A projector/backprojector with slice-to-slice blurring forefficient three-dimensional scatter modeling

Scatter correction is an important factor in single photon emission computed tomography (SPECT). Many scatter correction techniques, such as multiple-window subtraction and intrinsic modeling with iterative algorithms, have been under study for many years. Previously, we developed an efficient slice-to-slice blurring technique to model attenuation and system geometric response in a projector/backprojector pair, which was used in an ML-EM algorithm to reconstruct SPECT data. This paper proposes a projector/backprojector that models the three-dimensional (3-D) first-order scatter in SPECT, also using an efficient slice-to-slice blurring technique. The scatter response is estimated from a known nonuniform attenuation distribution map. It is assumed that the probability of detection of a first-order scattered photon from a photon that is emitted in a given source voxel and scattered in a given scatter voxel is proportional to the attenuation coefficient value at that voxel. Monte Carlo simulations of point sources and an MCAT torso phantom were used to verify the accuracy of the proposed projector/backprojector model. An experimental Jaszczak torso/cardiac phantom SPECT study was also performed. For a 64 x 64 x 64 image volume, it took 8.7 s to perform each iteration per slice on a Sun ULTRA Enterprise 3000 (167 MHz, 1 Gbyte RAM) computer, when modeling 3-D scatter, attenuation, and system geometric response functions. The main advantage of the proposed method is its easy implementation and the possibility of performing reconstruction in clinically acceptable time.     

Comparison of three applications of ConTraSPECT

Today, the trend in SPECT attenuation correction is to acquire a transmission data set and reconstruct the corresponding attenuation map, for incorporating into the emission reconstruction. Recently, some techniques have been developed to determine the attenuation map directly from the emission data, by exploiting the fact that in the absence of noise only some specific transmission data can be consistent with given emission data. However it is necessary to include some a priori information so that the consistency conditions can be used in an efficient manner. Here, three types of priors are used: a uniform ellipse, a uniform spline curve, and a uniform spline curve knowing the untruncated part of the transmission sinogram. Once the corresponding attenuation map has been computed, it is used to correct for attenuation in the emission image reconstruction process. The three methods have been tested on both simulations and experimentally acquired data. The results show that the two first methods give equally acceptable results, while the third method provides reconstructions which are closer to reconstructions obtained when the attenuation map is computed from untruncated transmission data     

Total variation regulated EM algorithm [SPECT reconstruction]

An iterative Bayesian reconstruction algorithm based on the total variation (TV) norm constraint is proposed. The motivation for using TV regularization is that it is extremely effective for recovering edges of images. This paper extends the TV norm minimization constraint to the field of SPECT image reconstruction with a Poisson noise model. The regularization norm is included in the OSL-EM (one step late expectation maximization) algorithm. Unlike many other edge-preserving regularization techniques, the TV based method depends one parameter. Reconstructions of computer simulations and patient data show that the proposed algorithm has the capacity to smooth noise and maintain sharp edges without introducing over/under shoots and ripples around the edges     

TNF-induced superoxide anion production in adherent human neutrophils involves both the p55 and p75 TNF receptor

TNF, a potent activator of neutrophil granulocytes, acts via two cell-surface receptors: the p55-TNF receptor (TNF-R55) and the p75-TNF receptor (TNF-R75), which can be cleaved from the cell surface and thus form soluble TNF-binding proteins (TNF-BP). The role of the two receptors in activation of the neutrophil respiratory burst was investigated. Two mAbs reacting with TNF-R55 (H398 and TBP2) induced O2 release in a similar manner but to a lesser extent than TNF. TBP2, however, required preincubation at 4 degrees C to exert its effect. Preincubation of neutrophils (both at 4 and 37 degrees C) with mAb to TNF-R75 decreased TNF-induced superoxide anion production by 67 and 64%, respectively, indicating the essential role also for TNF-R75 in neutrophil activation. This inhibitory effect could not be explained by cross-down-regulation of TNF-R55 because the TNF-R75 mAb had no effect on TNF binding to TNF-R55 as determined by binding of 125I-labeled TNF or release of TNF-R55-BP as measured by ELISA. Furthermore, the TNF-R75 mAb did not decrease superoxide anion generation induced by the TNF-R55 mAb H398, thus ruling out that the inhibitory effect of the TNF-R75 mAb is due to inhibition of the signaling pathway downstream of TNF-R55. In contrast to the TNF-R75 mAb, TNF-R55 mAbs induced down-regulation of TNF-R75 and shedding of both TNF-R55-BP and TNF-R75-BP. We conclude that both TNF-R55 and TNF-R75 are involved in TNF-induced activation of the neutrophil respiratory burst.     

Embrittlement of a continuously cooled Fe-25 Cr alloy

A study has been carried out on the effects of isothermal heat treatment at 475 and 550‡C and of continuous cooling at different rates from 850°C on the brittleness (as assessed by the ductile-brittle impact transition temperature) of a vacuum melted Fe-25 Cr alloy. The ductile-brittle transition temperature was found to be the lowest for the water quenched condition and highest for the furnace cooled condition and for material aged at 475‡C for long times (~500 h). An increase of brittleness with decreased cooling rate in the continuously cooled samples is attributed to the formation of more continuous and larger amounts of chromium nitrides and carbonitrides at the grain boundaries. Very little or no body centered cubic chromium-rich phase (alpha prime), associated with 475°C embrittlement, was observed. On aging at 550°C, the increased brittleness with time is also accounted for by the formation of grain boundary nitrides and carbonitrides. Although a similar effect takes place in the alloy heat treated at 475°C, the precipitation of alpha prime after long aging times enhances the brittleness. The tendency towards a more brittle condition with aging treatment and slower cooling rate is explained in terms of the Cottrell theory for brittle fracture.     

Chloroquine retinopathy in patients with rheumatoid arthritis

The paper presents data on the differential fertility of schizophrenics and controls, and the fertility of their siblings. This study used several methodological procedures in the study of schizophrenia reproduction, which strengthens the validity of the findings. Firstly, both male and female rates were examined. Secondly, the method of selection of a control avoided the biases introduced by using census data or other non-matched controls. Third, a diagnostic criterion was used which minimizes the possibility of the inclusion of other psychiatric illnesses. The results obtained support prior reports of the lowered reproductive rates of schizophrenics. Further, the siblings of schizophrenics were found not to have a reproductive advantage when contrasted to control siblings. The failure to find a reproductive advantage conflicts with a hypothesis of a balanced polymorphism as the mechanism maintaining an apparent constant rate of schizophrenia.     

The Use of Filtering Methods to Compensate for Constant Attenuation in Single-Photon Emission Computed Tomography

A back projection of filtered projection (BKFIL) reconstruction algorithm is presented that is applicable to single-photon emission computed tomography (ECT) in the presence of a constant attenuating medium such as the brain. The filters used in transmission computed tomography (TCT)-comprised of a ramp multiplied by window functions?are modified so that the single-photon ECT filter is a function of the constant attenuation coefficient. The filters give good reconstruction results with sufficient angular and lateral sampling. With continuous samples the BKFIL algorithm has a point spread function that is the Hankel transform of the window function. The resolution and statistical properties of the filters are demonstrated by various simulations which assume an ideal detector response. Statistical formulas for the reconstructed image show that the square of the percent-root-mean-square (percent-rms) uncertainty of the reconstruction is inversely proportional to the total measured counts. The results indicate that constant attenuation can be compensated for by using an attenuation-dependent filter that reconstructs the transverse section reliably. Computer time requirements are two times that of conventional TCT or positron ECT and there is no increase in memory requirements.     

Learned helplessness and its correlation to impairment, pain, anxiety and depression in rheumatoid arthritis

A Swedish version of the self-report instrument Arthritis Helplessness Index (AHI) is presented. Validity and reliability of the translation has been analyzed. 100 consecutive patients with rheumatoid arthritis (RA) were studied, 78 of which completed 2 self-administered questionnaires with AHI, impairment, pain, anxiety and depression. Furthermore 20 of the patients were interviewed with regard to AHI. Forty-two other patients with RA were analyzed for correlation between AHI and biochemical activity and Signals of Functional Impairment (SOFI). We conclude that the Swedish version of AHI has satisfactory validity and reliability. It correlates with age, physical impairment, pain, anxiety and depression but not with sex or disease activity. Five of the original 15 items could for various reasons be omitted, leaving a 10 statement instrument. AHI is promising as a variable in future outcome studies of RA.     

Tumours of the central nervous system and serum sialic acid concentration in men and women

In a population-based study serum sialic acid level was examined in relation to subsequent development of central nervous system (CNS) tumours (229 cases). Significantly increased sialic acid concentration was found in men with a malignant CNS tumour diagnosed within 8 years of analysis, compared with corresponding matched controls. These findings suggest that the tumour existed at the time of examination which is supported by a negative linear association between sialic acid level and the time from screening to tumour diagnosis.     

Convolutional reconstruction algorithm for fan beam concave and convex circular detectors

A modified convolution-backprojection reconstruction algorithm for a circular detector with an arbitrary radius of curvature has been derived for fan-beam geometries. The algorithm reduces to conventional fan-beam algorithms for flat detectors and for curved detectors having whose radii of curvature coincident with the X-ray tube focal spot. The algorithm substitutes a power series of convolution integrals in place of a single convolution integral. Computer simulations have verified the validity of the algorithm for a detector that curves away from the X-ray source. In this case, it has been demonstrated that good reconstructions are obtained when only a few of the terms of the power series are retained. The development of this algorithm represents a first step toward a cone-beam reconstruction algorithm that eventually will be used for an image-intensifier-based computerized-tomography volume imager being developed in the authors' laboratory.