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101.
Siew Hui Voon Lik Voon Kiew Hong Boon Lee Siang Hui Lim Mohamed Ibrahim Noordin Anyanee Kamkaew Kevin Burgess Lip Yong Chung 《Small (Weinheim an der Bergstrasse, Germany)》2014,10(24):4993-5013
Animal models, particularly rodents, are major translational models for evaluating novel anticancer therapeutics. In this review, different types of nanostructure‐based photosensitizers that have advanced into the in vivo evaluation stage for the photodynamic therapy (PDT) of cancer are described. This article focuses on the in vivo efficacies of the nanostructures as delivery agents and as energy transducers for photosensitizers in animal models. These materials are useful in overcoming solubility issues, lack of tumor specificity, and access to tumors deep in healthy tissue. At the end of this article, the opportunities made possible by these multiplexed nanostructure‐based systems are summarized, as well as the considerable challenges associated with obtaining regulatory approval for such materials. The following questions are also addressed: (1) Is there a pressing demand for more nanoparticle materials? (2) What is the prognosis for regulatory approval of nanoparticles to be used in the clinic? 相似文献
102.
Obead Yaseen Maher M. El‐Masri Wasim S. El Nekidy Derrick Soong Mohammed Ibrahim John W. Speirs Albert Kadri 《Hemodialysis international. International Symposium on Home Hemodialysis》2013,17(3):434-440
Hemodialysis catheter (HDC) dysfunction due to thrombosis is common, and dysfunction incidence can reach up to 50% within 1 year of use. Although administration of intraluminal alteplase (tissue plasminogen activator [tPA]) is the standard of practice to pharmacologically restore HDC function, there are no evidence‐based guidelines concerning the optimal tPA dose. The purpose of this study was to compare the efficacy of 1.0‐mg vs. 2.0‐mg tPA dwell protocols in restoring the HDC function in thrombotic dysfunctional catheters. A retrospective, single‐center study was conducted on two independent cohorts of patients; the first (n = 129) received 2.0 mg tPA/catheter lumen, while the second (n = 108) received 1.0 mg tPA/catheter lumen. Kaplan–Meier and Cox regression analyses were performed to compare the catheter survival time between patients who received 1.0 mg tPA and those who received 2.0 mg tPA. Catheter removal occurred in 25 (19.4%) of those catheters treated with 1.0 mg tPA compared with 11 (10.2%) of catheters treated with 2.0 mg tPA (P = 0.05). The hazard ratio (HR) for catheter removal was 2.75 (95% confidence interval [95%CI] = 1.25–6.04) for the 1.0‐mg tPA cohort compared with the 2.0‐mg tPA cohort. Correction added on 3 December 2012, after first online publication: The tPA cohort values were changed. Female gender (HR = 2.51; 95%CI = 1.20–5.27) and age (HR = 0.96; 95%CI = 0.94–0.98) were also associated with catheter survival. Our findings suggest that treatment of dysfunctional HDC with 2.0‐mg tPA dwells is superior to 1.0‐mg tPA dwells. 相似文献
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105.
Ahmed AbdelMonteleb M. Ali Abdelazim M. Negm Mahmoud F. Bady Mona G. E. Ibrahim Masaaki Suzuki 《Clean Technologies and Environmental Policy》2016,18(4):1053-1068
Egypt in 2015 announced the alteration of the fuels used in cement plants without the least regard to minimizing the environmental burden (EB) excesses. This study conducts a life-cycle assessment (LCA) of Egyptian cement-manufacturing unit, which is considered as the first one on LCA cement analysis to be conducted in Egypt. This study investigates the LCA of the cement industry in Egypt compared to the Swiss industry, using two methodologies. The first one has been done on-site, surveying the most common types of cement used in the construction industry in Egypt. Meanwhile, SimaPro software has been used to assess the environmental impacts, and three different cement plants were selected for this study: an Egyptian cement plant (ECP) which uses electricity, natural gas, and diesel as energy sources; a Swiss cement plant (SCP) which depends mainly on electricity, natural gas, and coal; and an Egyptian hypothetical plant (EHP) in which electricity and coal are assumed to be the main energy feeds, and comparisons of different strategies including midpoint and endpoint methods are outlined. Regarding the midpoint method, ETP recorded higher respiratory inorganics, aquatic acidification, global warming, and nonrenewable energy impacts than ECP, because of using coal, while for SCP, global warming and respiratory inorganics achieved the highest adverse impacts compared to ECP and EHP—due to the different manufacturing technology used. With regard to the endpoint method, the peak possibility of human health deterioration has been recorded due to the use of coal as fuel. This possibility was reduced by 46 % in the case of SCP as a result of the technology applied, which interestingly represents a reasonable reduction in terms of technological application. 相似文献
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107.
A single-basin solar still was constructed from locally available materials to concentrate palm tree juice (neera) for jaggery-making application. The performance of the still was tested with and without an acrylic mirror booster on both partially cloudy and clear sunshine days. About 73% of water content from neera was evaporated within 2 days by using the mirror booster technique in clear sunshine days. Distilled water of about 7.26 l was extracted from 10 l of neera with the mirror booster condition. Wind velocity showed a considerable effect on neera juice temperature and water vapour temperature during partially cloudy conditions. The calculated efficiency of the still with the mirror booster technique was 36.53% in clear sunshine conditions. The calculated energy conservation for the neera concentration process by using the mirror booster solar still was about 16408 kJ. 相似文献
108.
In wireless sensor network applications where data gathered by different sensor nodes is correlated, not all sensor nodes need to be active for the wireless sensor network to be functional. Given that the sensor nodes that are selected as active form a connected wireless network, the inactive sensor nodes can be turned off. Allowing some sensor nodes to be active and some sensor nodes inactive interchangably during the lifecycle of the application helps the wireless sensor network to have a longer lifetime. The problem of determining a set of active sensor nodes in a correlated data environment for a fully operational wireless sensor network can be formulated as an instance of the connected correlation-dominating set problem. In this work, our contribution is twofold; we propose an effective and runtime-efficient iterative improvement heuristic to solve the active sensor node determination problem, and a benefit function that aims to minimize the number of active sensor nodes while maximizing the residual energy levels of the selected active sensor nodes. Extensive simulations we performed show that the proposed approach achieves a good performance in terms of both network lifetime and runtime efficiency. 相似文献
109.
Ibrahim A. Abbas 《Journal of Mechanical Science and Technology》2014,28(10):4193-4198
The thermoelastic interaction in an unbounded medium with a spherical cavity is studied using two-temperature generalized thermoelasticity theory. The medium is assumed to be initially quiescent. The inner surface of the cavity is taken traction free and subjected to a thermal shock. By the Laplace transformation, the basic equations are expressed in the form of a vector-matrix differential equation, which is solved by an eigenvalue approach. Some comparison have been shown in figures to estimate the effect of the two-temperature parameter. 相似文献
110.
Gra?yna A. P?aza Joanna Chojniak Ibrahim M. Banat 《International journal of molecular sciences》2014,15(8):13720-13737
Developing a reliable experimental protocol for the synthesis of nanomaterials is one of the challenging topics in current nanotechnology particularly in the context of the recent drive to promote green technologies in their synthesis. The increasing need to develop clean, nontoxic and environmentally safe production processes for nanoparticles to reduce environmental impact, minimize waste and increase energy efficiency has become essential in this field. Consequently, recent studies on the use of microorganisms in the synthesis of selected nanoparticles are gaining increased interest as they represent an exciting area of research with considerable development potential. Microorganisms are known to be capable of synthesizing inorganic molecules that are deposited either intra- or extracellularly. This review presents a brief overview of current research on the use of biosurfactants in the biosynthesis of selected metallic nanoparticles and their potential importance. 相似文献