Flexible Blade‐Coated Multicolor Polymer Light‐Emitting Diodes for Optoelectronic Sensors

A method to print two materials of different functionality during the same printing step is presented. In printed electronics, devices are built layer by layer and conventionally only one type of material is deposited in one pass. Here, the challenges involving printing of two emissive materials to form polymer light‐emitting diodes (PLEDs) that emit light of different wavelengths without any significant changes in the device characteristics are described. The surface‐energy‐patterning technique is utilized to print materials in regions of interest. This technique proves beneficial in reducing the amount of ink used during blade coating and improving the reproducibility of printed films. A variety of colors (green, red, and near‐infrared) are demonstrated and characterized. This is the first known attempt to print multiple materials by blade coating. These devices are further used in conjunction with a commercially available photodiode to perform blood oxygenation measurements on the wrist, where common accessories are worn. Prior to actual application, the threshold conditions for each color are discussed, in order to acquire a stable and reproducible photoplethysmogram (PPG) signal. Finally, based on the conditions, PPG and oxygenation measurements are successfully performed on the wrist with green and red PLEDs.     

On the deformation and failure of Al 6061-T6 in plane strain tension evaluated through in situ microscopy

We investigate deformation and failure of Al 6061-T6 in plane strain conditions through in situ scanning electron microscopy. The global behavior of the specimen, as well as the local deformation of the matrix material, second phase particles, and preexisting voids, is observed with a combination of high temporal/low spatial resolution images and low temporal/high spatial resolution images. It is found that the matrix dominates the deformation response, with the second phase particles and voids imparting little influence on the deformation under the moderate triaxiality levels encountered in this experiment. The initiation or nucleation of cracks is observed to occur by plastic slip.     

Experiments and Simulations on the Cleaning of a Swellable Soil in Plane Channel Flow

ABSTRACT

The cleaning behavior of a soil with physical properties that depend on the wetting time is studied experimentally via the local phosphorescence detection method and simulated numerically in fully developed plane channel flow for Reynolds numbers up to 30,000. A computationally inexpensive general cleaning model is proposed, adopting an existing removal model and coupling it to the turbulent flow field. The influence of the soil on the flow is neglected and the transient behavior of the soil during cleaning is modeled in the form of a transient Dirichlet boundary condition. This approach is innovative for computational fluid dynamics of this phenomenon. The way of determining the model parameters from the experiment is described. The comparison of the simulation results with experimental data reveals very good suitability of the model in the case of a starch soil. A similar good agreement is found for data for a model protein foulant in tube flow from the literature.     

Nonlinear modeling of transformers

The performance of classical transformer models under nonsinusoidal excitation is investigated and two novel models for such analysis, both of which account for the transformer core magnetic nonlinearities, are presented. All analytical results are compared with experimental data     

Implementing evidence-based recommendations for health care: a roundtable comparing European and American experiences

BACKGROUND: A roundtable held October 5-6 1999, in Maidstone, Kent, United Kingdom, was convened to identify current strategies and ongoing challenges in implementing evidence-based practice guidelines in health care. Despite numerous new medical research findings for improving health care and despite the dissemination of many practice guidelines, the recommendations from these efforts are not being uniformly adopted. Overuse, underuse, and misuse plague the practice of medicine today. IMPLEMENTING GUIDELINES: Multiple implementation strategies are more likely to succeed that a single implementation method; local selection and adaptation of guidelines are critical; and reminders, educational outreach (for prescribing), and interactive educational workshops are generally effective. EXPERIENCE IN EUROPE: In most countries, guideline development has progressed from consensus conference, to evidence-based statements, and finally to evidence-based guidelines that also consider cost-effectiveness. Guideline development is the most advanced in The Netherlands, where physicians have coordinated their efforts with the government to achieve more uniformity than is found elsewhere. EXPERIENCE IN THE UNITED STATES: Designing systems that will facilitate change--not changing physician behavior--should be the focus. The concern for effecting improvement in health care is now more acute because of the increased attention being given to medical errors and patient safety. SUMMARY STATEMENT: Multifaceted approaches are clearly the most important method for improving care. Such approaches may include many improvement methods, none of which work well alone most of the time or any of the time.     

Link between heart disease, cholesterol, and Alzheimer's disease: a review

Increased prevalence of Alzheimer's disease-like beta-amyloid deposits in the neuropil and within neurons occurs in the brains of non-demented individuals with heart disease. Heart disease is a prevalent finding in Alzheimer's disease, and may be a forerunner to the dementing disorder. In the cholesterol-fed rabbit model of human coronary heart disease there is production and accumulation of beta-amyloid in the brain. This accumulation of beta-amyloid can be reversed by removing cholesterol from the rabbits' diet. In culture cells, a cholesterol challenge has been shown to increase production of beta-amyloid, and dramatic reductions of cholesterol produced by HMG Co-A reductase inhibitors decrease production of beta-amyloid. Increased beta-amyloid production is also produced by dietary cholesterol in a number of transgenic mouse models of Alzheimer's disease. Administration of HMG Co-A reductase inhibitors may block beta-amyloid production caused by dietary cholesterol in rabbits. Clinical trials testing the benefit of HMG Co-A reductase inhibitors in the treatment of Alzheimer's disease are underway.     

Thermal Expansion of La1.85Sr0.15CuO4 in Magnetic Fields up to 14 Tesla

We present thermal expansion measurements on a La_1.85Sr_0.15CuO₄ single crystal in external magnetic fields. Clear anomalies of the thermal expansion are observed at the superconducting transition. We have studied in detail the anisotropic influence of external fields on the anomalies. As expected, the field dependence is maximum for B c and minimum for B c. The measured angular dependence corresponds to that of an anisotropic 3d superconductor with an anisotropy parameter 18.     

In vivo local determination of tissue optical properties: applications to human brain

Local and superficial near-infrared (NIR) optical-property characterization of turbid biological tissues can be achieved by measurement of spatially resolved diffuse reflectance at small source-detector separations (<1.4 mm). However, in these conditions the inverse problem, i.e., calculation of localized absorption and the reduced scattering coefficients, is necessarily sensitive to the scattering phase function. This effect can be minimized if a new parameter of the phase function gamma, which depends on the first and the second moments of the phase function, is known. If gamma is unknown, an estimation of this parameter can be obtained by the measurement, but the uncertainty of the absorption coefficient is increased. A spatially resolved reflectance probe employing multiple detector fibers (0.3-1.4 mm from the source) is described. Monte Carlo simulations are used to determine gamma, the reduced scattering and absorption coefficients from reflectance data. Probe performance is assessed by measurements on phantoms, the optical properties of which were measured by other techniques [frequency domain photon migration (FDPM) and spatially resolved transmittance]. Our results show that changes in the absorption coefficient, the reduced scattering coefficient, and gamma can be measured to within +/-0.005 mm(-1), +/-0.05 mm(-1), and +/-0.2, respectively. In vivo measurements performed intraoperatively on a human skull and brain are reported for four NIR wavelengths (674, 811, 849, 956 nm) when the spatially resolved probe and FDPM are used. The spatially resolved probe shows optimum measurement sensitivity in the measurement volume immediately beneath the probe (typically 1 mm(3) in tissues), whereas FDPM typically samples larger regions of tissues. Optical-property values for human skull, white matter, scar tissue, optic nerve, and tumors are reported that show distinct absorption and scattering differences between structures and a dependence on the phase-function parameter gamma.