CAR T Cell Therapy in Hematological Malignancies: Implications of the Tumor Microenvironment and Biomarkers on Efficacy and Toxicity

Chimeric antigen receptor (CAR) T cell therapy has ushered in a new era in cancer treatment. Remarkable outcomes have been demonstrated in patients with previously untreatable relapsed/refractory hematological malignancies. However, optimizing efficacy and reducing the risk of toxicities have posed major challenges, limiting the success of this therapy. The tumor microenvironment (TME) plays an important role in CAR T cell therapy’s effectiveness and the risk of toxicities. Increasing research studies have also identified various biomarkers that can predict its effectiveness and risk of toxicities. In this review, we discuss the various aspects of the TME and biomarkers that have been implicated thus far and discuss the role of creating scoring systems that can aid in further refining clinical applications of CAR T cell therapy and establishing a safe and efficacious personalised medicine for individuals.     

Topological holographic quench dynamics in a synthetic frequency dimension

The notion of topological phases extended to dynamical systems stimulates extensive studies, of which the characterization of nonequilibrium topological invaria...     

探针系统反应特性与参数选择研究

用于流场测量的探针针孔孔径小,压力反应缓慢,影响试验精度和进度。本文提出了探针系统针孔压力给定测量粗度的反应时间的计算方法,对三种系统测定水流场和测定空气流场的反应特性进行了比较,分析了压力反应时间的影响因素,给出了合理的系统和系统参数,以提高测试精度,缩短试验时间。     

Influence of bearing damping on instability of asymmetric shafts, part IV: Effects of fluid-film bearings

The influence of fluid-film bearings on the parametric instability of asymmetric shafts is investigated. Since fluid-film bearings may have non-isotropic stiffness and damping, the system equations are time-varying coefficients in a rotating reference frame and the complete solution of transition curves includes coupled modes. Thus, the analytical modal method provided by our previous studies has been modified in this part for the determination of approximate solutions from a truncated Hill's determinant. In numerical examples, a plain cylindrical type and a tilting four-pad type are considered to estimate the effects of bearing parameters concerning static load, oil viscosity, and clearance on unstable regions.     

电机铁芯扭槽叠扣冲压控制系统

为高速冲床设计一附加控制系统,以实现在电机铁芯加工中任意扭槽的叠扣冲压,给出了该系统的控制原理图和软件框图.     

一种基于无线传输的智能LED显示屏的设计与实现

介绍了一种采用无线传输技术和LED大屏幕显示技术相结合,利用无线收发的方式来更新LED大屏幕显示的信息的实现方法。     

基于柯氏熵的汽车发动机状态预测的可行性研究

由于非线性系统存在长期不可预测性，基于此，建立了基于时间序列的柯尔莫哥洛夫熵求解方法，并利用柯尔莫哥洛夫熵求取了复杂机械系统状态的最大可预测的点数。这一研究为确立复杂设备状态预测的可信区间提供了理论支持，所获得的方法为复杂机械系统状态预测的可预测时间的界定提供了行之有效的技术方法。