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51.
Chun‐Wei Liu Chi‐Hung Lee Shih‐Chieh Lin 《Journal of the Society for Information Display》2012,20(12):646-652
This study proposes a roll‐to‐roll process‐based sub‐wavelength grating, which is attached on a light bar to turn the side‐lit red/green/blue (620, 520, and 450 nm) incident rays into a uniformly and normally output white light with high illuminance from the light bar's surface. On the basis of the rigorous coupling wave analysis, the relationship between the first‐order transmission/reflection efficiency and the pitch of the gratings with different shapes was analyzed. The optimal design can effectively reduce the coupling length and enhance the white color balance for display applications. 相似文献
52.
Scalable influence maximization for independent cascade model in large-scale social networks 总被引:2,自引:0,他引:2
Influence maximization, defined by Kempe et al. (SIGKDD 2003), is the problem of finding a small set of seed nodes in a social network that maximizes the spread of influence under certain influence cascade models. The scalability of influence maximization is a key factor for enabling prevalent viral marketing in large-scale online social networks. Prior solutions, such as the greedy algorithm of Kempe et al. (SIGKDD 2003) and its improvements are slow and not scalable, while other heuristic algorithms do not provide consistently good performance on influence spreads. In this article, we design a new heuristic algorithm that is easily scalable to millions of nodes and edges in our experiments. Our algorithm has a simple tunable parameter for users to control the balance between the running time and the influence spread of the algorithm. Our results from extensive simulations on several real-world and synthetic networks demonstrate that our algorithm is currently the best scalable solution to the influence maximization problem: (a) our algorithm scales beyond million-sized graphs where the greedy algorithm becomes infeasible, and (b) in all size ranges, our algorithm performs consistently well in influence spread—it is always among the best algorithms, and in most cases it significantly outperforms all other scalable heuristics to as much as 100–260% increase in influence spread. 相似文献
53.
Nguyen Khanh Toan Nguyen Chi Tai Soo-A Kim Sang-Gun Ahn 《International journal of molecular sciences》2021,22(1)
Salivary gland dysfunction induces salivary flow reduction and a dry mouth, and commonly involves oral dysfunction, tooth structure deterioration, and infection through reduced salivation. This study aimed to investigate the impact of aging on the salivary gland by a metabolomics approach in an extensive aging mouse model, SAMP1/Klotho -/- mice. We found that the salivary secretion of SAMP1/Klotho -/- mice was dramatically decreased compared with that of SAMP1/Klotho WT (+/+) mice. Metabolomics profiling analysis showed that the level of acetylcholine was significantly decreased in SAMP1/Klotho -/- mice, although the corresponding levels of acetylcholine precursors, acetyl-CoA and choline, increased. Interestingly, the mRNA and protein expression of choline acetyltransferase (ChAT), which is responsible for catalyzing acetylcholine synthesis, was significantly decreased in SAMP1/Klotho -/- mice. The overexpression of ChAT induced the expression of salivary gland functional markers (α–amylase, ZO-1, and Aqua5) in primary cultured salivary gland cells from SAMP1/Klotho +/+ and -/- mice. In an in vivo study, adeno-associated virus (AAV)-ChAT transduction significantly increased saliva secretion compared with the control in SAMP1/Klotho -/- mice. These results suggest that the dysfunction in acetylcholine biosynthesis induced by ChAT reduction may cause impaired salivary gland function 相似文献
54.
Ming-Hui Yang Yi-Ming Arthur Chen Shan-Chen Tu Pei-Ling Chi Kuo-Pin Chuang Chin-Chuan Chang Chiang-Hsuan Lee Yi-Ling Chen Che-Hsin Lee Cheng-Hui Yuan Yu-Chang Tyan 《International journal of molecular sciences》2021,22(6)
Glycine N-methyltransferase (GNMT) regulates S-adenosylmethionine (SAMe), a methyl donor in methylation. Over-expressed SAMe may cause neurogenic capacity reduction and memory impairment. GNMT knockout mice (GNMT-KO) was applied as an experimental model to evaluate its effect on neurons. In this study, proteins from brain tissues were studied using proteomic approaches, Haemotoxylin and Eosin staining, immunohistochemistry, Western blotting, and ingenuity pathway analysis. The expression of Receptor-interacting protein 1(RIPK1) and Caspase 3 were up-regulated and activity-dependent neuroprotective protein (ADNP) was down-regulated in GNMT-KO mice regardless of the age. Besides, proteins related to neuropathology, such as excitatory amino acid transporter 2, calcium/calmodulin-dependent protein kinase type II subunit alpha, and Cu-Zn superoxide dismutase were found only in the group of aged wild-type mice; 4-aminobutyrate amino transferase, limbic system-associated membrane protein, sodium- and chloride-dependent GABA transporter 3 and ProSAAS were found only in the group of young GNMT-KO mice and are related to function of neurons; serum albumin and Rho GDP dissociation inhibitor 1 were found only in the group of aged GNMT-KO mice and are connected to neurodegenerative disorders. With proteomic analyses, a pathway involving Gonadotropin-releasing hormone (GnRH) signal was found to be associated with aging. The GnRH pathway could provide additional information on the mechanism of aging and non-aging related neurodegeneration, and these protein markers may be served in developing future therapeutic treatments to ameliorate aging and prevent diseases. 相似文献
55.
装配式凸轮轴滚花连接机理及连接强度研究 总被引:5,自引:1,他引:5
装配式凸轮轴与传统凸轮轴相比具有重量轻、加工成本低、材料利用合理等优点。是新型的凸轮轴制造技术, 具有广泛的发展空间。而其连接方法是装配式凸轮轴制造的关键技术。本文基于相异材料的咬合连接理论, 提出了滚花式塑性变形连接机理, 对不同材料、尺寸的滚花式凸轮轴静连接强度及疲劳强度进行了实验研究, 同时分析了滚花连接的不同连接状况以及凸轮压装张紧应力。 相似文献
56.
TA15合金的热变形行为及加工图 总被引:10,自引:0,他引:10
研究了TA15合金的热模拟压缩实验。结果表明:变形温度的升高和应变速率的减小使峰值应力和稳态应力显著降低,变形温度会影响进入稳态流动所需变形量。以热模拟压缩实验为基础,建立的加工图表明:TA15合金高温变形时存在2个非稳定区域,一个是变形温度1300K以上和应变速率10.0s^-1以上的区域,另一个是变形温度1200K以下和应变速率0.006s^-1~1.995s^-1之间的区域。同时,建立的TA15合金高温变形时的流动应力模型表征了变形温度、应变速率和变形程度对流动应力的影响,模型的计算精度较高。 相似文献
57.
WANG Zhongmin Chi Ying Vanessa Li ZHOU Huaiying Sammy Lap Ip Chan SHI Liu 《稀有金属(英文版)》2006,25(5):543-548
AB5-based hydrogen storage thin fdms (LaNi4.25Al0.75), deposited on Cu substrate by dc magnetron sputtering were investigated in this study. X-ray diffraction (XRD) revealed that the microstructure of the layer was in crystal form. SEM and AFM analyses proved that the film appeared to be rather rough with numerous randomly sized pores of approximately 15-40 in nm diameter. Structural stability of the film was examined by the combined analyses of DSC, XRD, and SEM, which indicated that this film maintained its structural stability below 500 K or so, and a network structure was observed on the film after being heated at 700 K for 30 min. Electrochemical hydrogen-storage properties of the films were investigated by simulated battery tests. It was found that single-layered LaNi4.25A10.75 film exhibited electrochemical hydrogen-storage properties similar to typical AB5 alloys in bulk, and the maximum discharge capacity of the film was about 220 mAh/g. After 20 charge/discharge cycles, small needle-shaped aluminium oxide was formed on some fractions of the film surface. 相似文献
58.
Aside from its importance as a design parameter for thermal barrier coatings, measuring thermal conductivity of thermal sprayed
coatings itself provides a unique method to critically characterize the nature, quantity, and anisotropy of the defect morphologies
in these splat-based coatings. In this paper, the authors present a systematic assessment of thermal conductivity of wide
range using the flash diffusivity technique. For the case of plasma sprayed yttria-stabilized zirconia (YSZ), coatings obtained
from wide-ranging initial powder morphologies as well as those fabricated under different particle states were characterized.
Both in-plane and through-thickness properties were obtained. Other material systems that were considered include: metallic
alloys and semiconductors of interests. Issues such as reproducibility and reliability in measurements were also considered
and assessed. Finally, work in collaboration with the Oak Ridge National Laboratory (ORNL) for alternate approaches to characterization
of thermal conductivity as well as high-temperature measurements was performed.
This article was originally published inBuilding on 100 Years of Success, Proceedings of the 2006 International Thermal Spray Conference (Seattle, WA), May 15–18, 2006, B.R. Marple, M.M. Hyland, Y.-Ch. Lau, R.S. Lima, and J. Voyer, Ed., ASM International, Materials
Park, OH, 2006. 相似文献
59.
双纵模热稳频激光源的模糊PID控制研究 总被引:4,自引:0,他引:4
为了满足激光拍频干涉仪所需要的高的频率稳定性的激光光源,研究了双纵模热稳频的机理。以控制激光管放电电流为主要热控制方式及自创的对激光管进行感应加热作为微量控制的先进方法为控制手段,采用模糊控制理论与专家系统相结合的控制策略,建立模糊PID控制器,对双纵模激光源进行稳频。无须建立被控对象数学模型,对时滞、非线形和时变性具有一定的适应能力。实验结果显示,稳频精度无明显变化,但预热时间明显缩短,抗干扰性明显增强,强干扰后也能迅速稳频。 相似文献
60.
Chi Nguyen Quynh Ho Minh Thi Tran Chung Chinh Doan Son Nghia Hoang Diem Hong Tran Long Thanh Le 《International journal of molecular sciences》2021,22(9)
Simulated microgravity (SMG) induced the changes in cell proliferation and cytoskeleton organization, which plays an important factor in various cellular processes. The inhibition in cell cycle progression has been considered to be one of the main causes of proliferation inhibition in cells under SMG, but their mechanisms are still not fully understood. This study aimed to evaluate the effects of SMG on the proliferative ability and cytoskeleton changes of Chang Liver Cells (CCL-13). CCL-13 cells were induced SMG by 3D clinostat for 72 h, while the control group were treated in normal gravity at the same time. The results showed that SMG reduced CCL-13 cell proliferation by an increase in the number of CCL-13 cells in G0/G1 phase. This cell cycle phase arrest of CCL-13 cells was due to a downregulation of cell cycle-related proteins, such as cyclin A1 and A2, cyclin D1, and cyclin-dependent kinase 6 (Cdk6). SMG-exposed CCL-13 cells also exhibited a downregulation of α-tubulin 3 and β-actin which induced the cytoskeleton reorganization. These results suggested that the inhibited proliferation of SMG-exposed CCL-13 cells could be associate with the attenuation of major cell cycle regulators and main cytoskeletal proteins. 相似文献