Poly(pentahydropyrimidine)-Based Hybrid Hydrogel with Synergistic Antibacterial and Pro-Angiogenic Ability for the Therapy of Diabetic Foot Ulcers

Bacterial infection and impaired angiogenesis make the treatment of diabetic foot ulcers (DFU) extremely challenging. Cationic polymers are expected to treat infected wounds due to their excellent antibacterial properties, but still, it is difficult to meet the therapeutic needs of pro-angiogenesis and anti-infections due to their simple construction units and outmoded synthesis methods. Herein, a cationic poly(pentahydropyrimidine) (PPHP) library with strong modifiability is synthesized to construct a hybrid hydrogel with synergistic therapeutic effects for the treatment of infected DFUs. It is found that the as-synthesized hybrid hydrogel can up-regulate angiogenesis-related gene (HIF-1, VEGF, and bFGFR/bFGF) expression and targeted disruption of bacterial cell membranes, which finally promotes the healing of infected DFU (wound healing rate: 92%) within 10 days. This hydrogel, thus, holds great promise in developing new strategies to significantly enhance the treatment of DFU and other bacterial-infected pathological diagnoses.     

Recent Advances in Mn-Rich Layered Materials for Sodium-Ion Batteries

Branded with low cost and a high degree of safety, with an ambitious aim of substituting lithium-ion batteries in many fields, sodium-ion batteries have received fervid attention in recent years after being dormant for decades. Layered materials are a major focus of study owing to the extensive experience already gained in lithium-ion batteries, and the pursuit of a Mn-rich composition is critical to reduce the cost while retaining the performance. This review provides a timely update of the recent progress of Mn-rich layered materials for sodium-ion batteries based on the understandings of the phase forming principles, structure transformation upon cycling and charge compensation mechanisms and discusses potential ambiguities in the pursuit of high-performance materials.     

Intrinsically Flexible and Aging Resistant Fluorene-Based Rod-Coil Copolymer for Bendable Deep-Blue PLEDs

In the field of flexible light-emitting display, goal-oriented intelligent molecular design is used to control various behaviors of molecules, which provides potential for the development of flexible light-emitting conjugated polymers (LCPs). The introduction of non-conjugated units into polymer molecules is a key prerequisite for realizing the intrinsic flexibility, but its easy interchain slip will also lead to the formation of interchain excited states, which is detrimental to the efficiency of light-emitting diodes. Herein, two kinds of fluorene-based rod-coil copolymer with stable deep blue emission characteristics is presented and with Commission Internationale de L'Eclairage (CIE) coordinates of (0.18, 0.14) and (0.15, 0.09), respectively. Surprisingly, the copolymer films show efficient blue emission even at 100% tension. Meanwhile, the rod-coil copolymer possesses better aging resistance compared to rigid π-conjugated counterparts. Finally, both rigid and flexible light-emitting diodes based on rod-coil copolymer exhibit stable deep blue emission, and the G2-based PLED with CIE coordinates of (0.16, 0.08), which approach National Television System Committee standard blue specification. These results confirm the validity of rod-coil copolymer design strategy in constructing inherently flexible polymers with deep blue emission, which have great application potential in flexible PLEDs.     

Mixed reality depth contour occlusion using binocular similarity matching and three-dimensional contour optimisation

Virtual Reality - Mixed reality applications often require virtual objects that are partly occluded by real objects. However, previous research and commercial products have limitations in terms of...     

融合双注意力机制的人群计数算法

针对背景复杂、遮挡、人群分布不均等人群计数常见问题,提出了一种结合联合损失的空间-通道双注意力机制卷积神经网络模型(joint loss-based space-channel dual attention network, JL-SCDANet).该网络前端进行图像粗粒度特征提取,中间加入空间注意力机制以及通道注意力机制突出图像重点区域,后端使用可加大感受野且不丢失图像分辨率的空洞卷积提取深层二维特征.此外,该模型结合联合损失函数进行训练,以增强模型的鲁棒性.为了验证模型的改进效果,在3个公共数据集(ShanghaiTech Part B、mall和UCF＿CC＿50)上分别进行了对比实验,在ShanghaiTech Part B数据集中平均绝对误差(MAE)和均方误差(MSE)分别达到了8.13和13.13;在mall数据集中MAE、MSE达到了1.78和2.28;在UCF＿CC＿50数据集中MAE、MSE分别达到了182.12和210.24,实验结果证明了该网络在提高人数统计准确率上的有效性.     

基于堆叠稀疏降噪自动编码器的地区风电场群高精度超短期风电功率预测

为解决风电功率预测过程中面临的风电数据量大且复杂化以及如何提高预测精度的问题,基于堆叠稀疏降噪自动编码器提出地区风电场群高精度超短期风电功率预测方法。该方法采用自编码器对输入风电功率数据进行降维提取特征,为进一步增强自动编码器的抗干扰性,对其引入稀疏性约束和降噪技术。该方法能够有效降低数据的解析难度和提高特征提取的可靠性。通过实际算例验证,该预测方法可有效提高多风电场功率预测的精度。     

考虑车辆充电调度机制的电动公交车充电站规划

针对电动公交车充电站的最佳充电容量难以确定及其充电效率低的问题,提出了一种在站址既定情况下考虑车辆充电调度机制的电动公交车充电站优化规划方法。首先,根据电动公交车的发车状态模拟电动公交车日常运行中的电能消耗,生成电动公交车的总运行负荷时序曲线;然后,基于生成的运行负荷时序曲线,构建充电需求度指标,制定电动公交车的充电调度机制;最后,在满足电动公交车充电需求的同时兼顾充电站精细化规划的要求,建立以充电能力最强、投资运行成本最小、光伏能源综合利用指标最大为优化目标的充电站多目标优化规划模型,并采用小生境多目标粒子群优化算法对该模型进行求解,以确定电动公交车充电站的充电桩数量以及光伏发电系统和配电变压器的容量。工程实例分析结果验证了所提方法的正确性和有效性。     

TBM试验台支撑推进节能系统设计与仿真分析

针对全断面硬岩隧道掘进机(hard rock tunnel boring machine,简称TBM)在撑靴以设定压力撑紧围岩后支撑推进系统存在较大流量损失的问题,设计出一种具有负载敏感、恒压控制和蓄能器辅助支撑功能的支撑推进(简称LSCPGT)系统。利用AMESim软件搭建了LSCPGT系统模型,仿真分析了LSDRGT系统在变推进负载下的压力流量响应,并对比分析了在支撑工况下LSCPGT系统和恒压控制泵型支撑(constant pressure gripper,CPG)系统,以及在推进工况下LSCPGT系统与负载敏感泵型推进(load-sensing thrust,LST)系统和定量泵型推进(ration thrust,RT)系统的压力流量响应.结果表明:LST系统和LSCPGT系统在推进过程中都没有流量损失;CPG系统在支撑工况下存在流量损失,而LSCPGT系统由于蓄能器的保压作用没有流量损失;相对于LST系统+CPG系统的支撑推进系统,LSCPGT系统在撑靴达到设定压力后效率至少可提高43.5%。所设计的LSCPGT系统在满足支撑推进要求的同时,避免了流量损失,具有较好的节能效果。     

White‐Emissive Self‐Assembled Organic Microcrystals

Organic semiconductor micro‐/nanocrystals with regular shapes have been demonstrated for many applications, such as organic field‐effect transistors, organic waveguide devices, organic solid‐state lasers, and therefore are inherently ideal building blocks for the key circuits in the next generation of miniaturized optoelectronics. In the study, blue‐emissive organic molecules of 1,4‐bis(2‐methylstyryl)benzene (o‐MSB) can assemble into rectangular microcrystals at a large scale via the room‐temperature solution‐exchange method. Because of the Förster resonance energy transfer, the energy of the absorbed photons by the host matrix organic molecules of o‐MSB can directly transfer to the dopant organic molecules of tetracene or 1,2:8,9‐dibenzopentacene (DBP), which then emit visible photons in different colors from blue to green, and to yellow. More impressively, by modulating the doping molar ratios of DBP to o‐MSB, bright white‐emissive organic microcrystals with well‐preserved rectangular morphology can be successfully achieved with a low doping ratio of 1.5%. These self‐assembled organic semiconductor microcrystals with multicolor emissions can be the white‐light sources for the integrated optical circuits at micro‐/nanoscale.     

气相色谱仪新旧检定规程的解读

本文主要从规程适用范围、计量器具控制、计量性能要求及检定方法等方面入手,全面的解读了气相色谱仪新旧检定规程的差异,为仪器检定及期间核查提供了参考。