Characterization of minocycline loaded chitosan/polyethylene glycol/glycerol blend films as antibacterial wound dressings

Wound care has been a challenging subject for medical teams and researchers. Bacterial infections are one of the most serious complications in injured skins that often affect healing process. Antibacterial wound dressings can be used to facilitate wound healing process. The purpose of this study is to fabricate chitosan (Chito)/polyethylene glycol (PEG) antibacterial wound dressing doped with minocycline, and to evaluate the influence of composition ratio on the blending properties of the films. To improve the mechanical properties of these films, we examined various amounts of glycerol as a plasticizer. Moreover, we investigated morphological and mechanical aspects, water uptake, degradation, water vapor transmission and wettability properties of the films prepared with various ratios of Chito/PEG/Gly. Assessment of mechanical properties revealed that film containing 80:20 ratio Chito/PEG with 40 PHR Gly content exhibits the highest ultimate tensile strength and elongation at break (9.74 MPa and 45.73% respectively). Furthermore, results demonstrated that upon increasing PEG and Gly contents, degradability and hydrophilicity of the films increased whereas water uptake decreased. Water vapor transmission rate of the films was close to the range of 530–1200 g/m²d, indicating that the as formed films are possible candidates for dressing low exudate wounds or burns. Minocycline loaded films exhibited a biphasic drug release profile and it was more effective on gram-positive bacteria than on gram-negative bacteria. The polymeric film with the highest amount of loaded drug (2%) exhibited insignificant cytotoxicity (88%) against normal fibroblast cell line.     

Infrared thermography for inspecting the adhesion integrity of plastic welded joints

This work aim at developing a non-destructive tool for the evaluation of bonded plastic joints. The paper examines infrared thermographic transmission and reflection mode imaging and validates the feasibility of the thermal NDT approach for this application. Results demonstrate good estimation performance for adhesion integrity, uniformity and bond strength using a transmission mode application of infrared thermography. In addition, results from a pulsed infrared thermographic application using a modified dynamic infrared tomography scheme show good performance for estimating adhesion layer thickness mapping and detecting delaminations.     

Studying the needed effort for identifying duplicate issues

Many recent software engineering papers have examined duplicate issue reports. Thus far, duplicate reports have been considered a hindrance to developers and a drain on their resources. As a result, prior research in this area focuses on proposing automated approaches to accurately identify duplicate reports. However, there exists no studies that attempt to quantify the actual effort that is spent on identifying duplicate issue reports. In this paper, we empirically examine the effort that is needed for manually identifying duplicate reports in four open source projects, i.e., Firefox, SeaMonkey, Bugzilla and Eclipse-Platform. Our results show that: (i) More than 50 % of the duplicate reports are identified within half a day. Most of the duplicate reports are identified without any discussion and with the involvement of very few people; (ii) A classification model built using a set of factors that are extracted from duplicate issue reports classifies duplicates according to the effort that is needed to identify them with a precision of 0.60 to 0.77, a recall of 0.23 to 0.96, and an ROC area of 0.68 to 0.80; and (iii) Factors that capture the developer awareness of the duplicate issue’s peers (i.e., other duplicates of that issue) and textual similarity of a new report to prior reports are the most influential factors in our models. Our findings highlight the need for effort-aware evaluation of approaches that identify duplicate issue reports, since the identification of a considerable amount of duplicate reports (over 50 %) appear to be a relatively trivial task for developers. To better assist developers, research on identifying duplicate issue reports should put greater emphasis on assisting developers in identifying effort-consuming duplicate issues.     

An empirical study of integration activities in distributions of open source software

Reuse of software components, either closed or open source, is considered to be one of the most important best practices in software engineering, since it reduces development cost and improves software quality. However, since reused components are (by definition) generic, they need to be customized and integrated into a specific system before they can be useful. Since this integration is system-specific, the integration effort is non-negligible and increases maintenance costs, especially if more than one component needs to be integrated. This paper performs an empirical study of multi-component integration in the context of three successful open source distributions (Debian, Ubuntu and FreeBSD). Such distributions integrate thousands of open source components with an operating system kernel to deliver a coherent software product to millions of users worldwide. We empirically identified seven major integration activities performed by the maintainers of these distributions, documented how these activities are being performed by the maintainers, then evaluated and refined the identified activities with input from six maintainers of the three studied distributions. The documented activities provide a common vocabulary for component integration in open source distributions and outline a roadmap for future research on software integration.     

A General Robust MPC Design for the State‐Space Model: Application to Paper Machine Process

Applying model predictive control (MPC) in some cases such as complicated process dynamics and/or rapid sampling leads us to poorly numerically conditioned solutions and heavy computational load. Furthermore, there is always mismatch in a model that describes a real process. Therefore, in this paper in order to prevail over the mentioned difficulties, we design a robust MPC using the Laguerre orthonormal basis in order to speed up the convergence at the same time with lower computation adding an extra parameter “a” in MPC. In addition, the Kalman state estimator is included in the prediction model and accordingly the MPC design is related to the Kalman estimator parameters as well as the error of estimations which helps the controller react faster against unmeasured disturbances. Tuning the parameters of the Kalman estimator as well as MPC is another achievement of this paper which guarantees the robustness of the system against the model mismatch and measurement noise. The sensitivity function at low frequency is minimized to tune the MPC parameters since the lower the magnitude of the sensitivity function at low frequency the better command tracking and disturbance rejection results. The integral absolute error (IAE) and peak of the sensitivity are used as constraints in optimization procedure to ensure the stability and robustness of the controlled process. The performance of the controller is examined via the controlling level of a Tank and paper machine processes.     

Studying re-opened bugs in open source software

Bug fixing accounts for a large amount of the software maintenance resources. Generally, bugs are reported, fixed, verified and closed. However, in some cases bugs have to be re-opened. Re-opened bugs increase maintenance costs, degrade the overall user-perceived quality of the software and lead to unnecessary rework by busy practitioners. In this paper, we study and predict re-opened bugs through a case study on three large open source projects—namely Eclipse, Apache and OpenOffice. We structure our study along four dimensions: (1) the work habits dimension (e.g., the weekday on which the bug was initially closed), (2) the bug report dimension (e.g., the component in which the bug was found) (3) the bug fix dimension (e.g., the amount of time it took to perform the initial fix) and (4) the team dimension (e.g., the experience of the bug fixer). We build decision trees using the aforementioned factors that aim to predict re-opened bugs. We perform top node analysis to determine which factors are the most important indicators of whether or not a bug will be re-opened. Our study shows that the comment text and last status of the bug when it is initially closed are the most important factors related to whether or not a bug will be re-opened. Using a combination of these dimensions, we can build explainable prediction models that can achieve a precision between 52.1–78.6 % and a recall in the range of 70.5–94.1 % when predicting whether a bug will be re-opened. We find that the factors that best indicate which bugs might be re-opened vary based on the project. The comment text is the most important factor for the Eclipse and OpenOffice projects, while the last status is the most important one for Apache. These factors should be closely examined in order to reduce maintenance cost due to re-opened bugs.     

Position control of electro-hydraulic actuator system using fuzzy logic controller optimized by particle swarm optimization

The position control system of an electro-hydraulic actuator system (EHAS) is investigated in this paper. The EHAS is developed by taking into consideration the nonlinearities of the system: the friction and the internal leakage. A variable load that simulates a realistic load in robotic excavator is taken as the trajectory reference. A method of control strategy that is implemented by employing a fuzzy logic controller (FLC) whose parameters are optimized using particle swarm optimization (PSO) is proposed. The scaling factors of the fuzzy inference system are tuned to obtain the optimal values which yield the best system performance. The simulation results show that the FLC is able to track the trajectory reference accurately for a range of values of orifice opening. Beyond that range, the orifice opening may introduce chattering, which the FLC alone is not sufficient to overcome. The PSO optimized FLC can reduce the chattering significantly. This result justifies the implementation of the proposed method in position control of EHAS.